Position-dependent effects of loop proline residues on Fab stability and aggregation [0.03%]
脯氨酸残基在抗体Fab片段的稳定性和聚集中的位置依赖效应
Ryosei Kawakami,Masato Kiyoshi,Hitomi Nakamura et al.
Ryosei Kawakami et al.
Proline residues play an important role in the structural stability of proteins because their cyclic side chains impose strong conformational constraints on the peptide backbone. However, the contribution of proline residues to the stabilit...
BIRC3 activates NF-κB to drive TNF-α-induced endothelial dysfunction in atherosclerosis [0.03%]
BIRC3通过激活NF-κB介导TNF-α诱导的动脉粥样硬化内皮功能障碍
Yongchun Cai,Pingang Liu
Yongchun Cai
Atherosclerosis, a chronic inflammatory arteriopathy, constitutes a principal contributor to cardiovascular events. Its pathogenesis commences with endothelial dysfunction elicited by pro-inflammatory mediators like TNF-α. The exact involv...
Reprogramming tumor angiogenesis in breast cancer: Mechanisms, challenges, and future directions [0.03%]
乳腺癌中肿瘤血管生成的重编程：机制、挑战与未来方向
Barnalee Mishra,Suryendu Saha,Kavita Kumari et al.
Barnalee Mishra et al.
Angiogenesis serves as a central hallmark of breast cancer progression by driving the formation of a dysfunctional vascular network that sustains tumor growth, enables metabolic adaptation, and facilitates metastasis. Hypoxia within the tum...
Hederagenin binds to monoamine oxidase A to activate chondrocyte autophagy in osteoarthritis therapy [0.03%]
槐果碱通过与单胺氧化酶A结合激活软骨细胞自噬以治疗骨关节炎
Baihui Yang,Jinxi Li,Junliang Lu et al.
Baihui Yang et al.
Background: The characteristics of osteoarthritis (OA) is the progressive degeneration of cartilage. Currently, the treatment strategies that can delay or reverse the degeneration of cartilage are still relatively limited...
Deciphering the role of human thiol systems (Trx/Grx) in the transcriptional regulation: An emphasis on the role of thiol enzymes with the multifunctional APE1/Ref-1 enzyme in human health and diseases [0.03%]
人类硫醇系统（Trx / Grx）在转录调控中的作用解析：多功能APE1 / Ref-1酶与硫醇酶的作用机制及其在人类健康和疾病中的作用
Prabhakar Gangwar,Bharti Yadav,Harkomal Verma et al.
Prabhakar Gangwar et al.
A thiol-dependent redox system exists in mammalian cells, which plays a critical role in maintaining the redox balance and protecting against oxidative damage. Thiol-containing proteins, which include glutaredoxin (Grx) and thioredoxin (Trx...
Drug library screening identifies colchicine and shikonin as therapeutic candidates for methotrexate-resistant choriocarcinoma [0.03%]
药物筛选识别到秋水仙素和紫草科化合物是甲氨蝶呤耐药性绒毛膜癌的治疗候选药物
Yuki Nishiko,Kosuke Yoshida,Akira Yokoi et al.
Yuki Nishiko et al.
Choriocarcinoma is a rare and aggressive form of gestational trophoblastic neoplasia, and methotrexate resistance remains a clinical challenge. In this study, we aimed to identify alternative therapeutic compounds that are effective against...
Direct current electric field induces non-linear NPFFR2 accumulation and alters its predicted conformational stability in murine thioglycolate-elicited peritoneal macrophages [0.03%]
直流电场诱导小鼠腹腔巨噬细胞中NPFFR2非线性积累并改变其预测的构象稳定性
Mengya Zhao,Yanwei Fang,Yunfei Chen et al.
Mengya Zhao et al.
Neuropeptide FF receptor 2 (NPFFR2) has been implicated in the bioelectric response of bone marrow-derived macrophages (BMDMs). However, given the functional heterogeneity of macrophage populations, the specific response of tissue macrophag...
JMJD5 promotes chemotherapy sensitivity of cisplatin in NSCLC by enhancing DNA damage [0.03%]
JMJD5通过增强DNA损伤促进顺铂对非小细胞肺癌的化疗敏感性
Jing He,Haohao Wei,Tao Li et al.
Jing He et al.
Background: Platinum-based chemotherapy remains a cornerstone in the treatment of advanced non-small cell lung cancer (NSCLC), yet its efficacy is frequently limited by drug resistance. JMJD5 (Jumonji Domain-Containing Pr...
Precision prime editing of TP53 mutations for functional tumor suppression in colorectal cancer [0.03%]
精确编辑TP53突变以在结直肠癌中实现肿瘤功能抑制
Md Azhar,Rishabha Malviya,Phool Chandra et al.
Md Azhar et al.
Background: Colorectal cancer (CRC) is a major global health concern, with high mortality due to genetic heterogeneity and resistance to treatment. Tumor Protein p53 (TP53) mutations are also among the most important mole...
Corrigendum to "Correlation of NADH/NAD+ electrochemical potential and enzymatic activity for investigating protein folding and kinetics" [Biochem. Biophys. Res. Commun. 750 (2025) 151393] [0.03%]
“关于NADH/NAD+电化学势和酶活性相关性研究的勘误说明（用于探究蛋白质折叠及动力学）”[ Biochem. Biophys. Res. Commun. 750 (2025) 151393]
Anurag Sinha,Ashish K Singh,Supriya Sharma et al.
Anurag Sinha et al.