Neuropeptide INS-14 modulates apoptotic cell clearance in Caenorhabditis elegans [0.03%]
神经肽INS-14通过调节细胞凋亡清除作用调控线虫寿命
Yunmin Xie,Lu Chen,Fuqiao Liu et al.
Yunmin Xie et al.
Apoptosis, a principal form of programmed cell death, is integral to animal development. Neuropeptides, which are crucial signaling molecules in the nervous system, play roles in various physiological and behavioral processes. Until now, th...
ALB suppresses epithelial-mesenchymal transition and glycolysis via SPARC regulation in metastatic clear cell renal cell carcinoma [0.03%]
通过调节SPARC抑制转移性透明细胞肾细胞癌的上皮间质转化和糖酵解
Wei Wang,Liuyang Shu,Sheng Xu et al.
Wei Wang et al.
Background: The most prevalent subtype of renal cell carcinoma is clear cell renal cell carcinoma (ccRCC). Approximately 20-30 % of ccRCC patients develop metastatic clear cell renal cell carcinoma (mccRCC), characterized...
Mechanistic insights and therapeutic potential of E3 ubiquitin ligases in gastric cancer development [0.03%]
泛素连接酶在胃癌发生发展中的机制及治疗潜力研究
Yao Xiao,Yalin Lei,Qian He et al.
Yao Xiao et al.
The ubiquitin-proteasome system (UPS) is the primary pathway for protein degradation in eukaryotic cells. E3 ubiquitin ligases regulate protein homeostasis through substrate-specific ubiquitination and play a crucial role in the onset, prog...
The role of the TLR2 gene in regulating proliferation of rabbit dermal papilla cells [0.03%]
TLR2基因对兔真皮乳头细胞增殖的调控作用
Yu Zhou,Bohao Zhao,Shaoning Sun et al.
Yu Zhou et al.
Hair follicle (HF) morphogenesis, growth, and regeneration are fundamentally governed by reciprocal interactions between the epidermal and dermal compartments of the skin, with dermal papilla cells (DPCs) serving as a central regulatory ele...
Crohn's disease under single-cell map: from INFLARE metaplastic cells to rare immune cell subpopulations [0.03%]
克罗恩病的单细胞图谱：从INFLARE元生细胞到罕见免疫细胞亚群
Qianwen Zhu,Wenhao Gu,Yuyang Lv et al.
Qianwen Zhu et al.
Crohn's disease (CD) is a chronic inflammatory condition of the gastrointestinal tract characterized by symptoms such as abdominal pain, diarrhea, weight loss, fever, and fatigue. Although the exact etiology of CD remains elusive, dysregula...
Role of WNK4 and FKBP5 in asthma: Insights from bioinformatics analysis, machine learning, and preliminary validation [0.03%]
WNK4和FKBP5在哮喘中的作用：来自生物信息学分析、机器学习及初步验证的启示
Meng Liu,Yue Li,Tianci Jiang et al.
Meng Liu et al.
Background: The complex and heterogeneous molecular mechanisms of asthma are currently unclear, and treatment outcomes are dismal in some patients. This study aimed to identify biomarkers with diagnostic and therapeutic p...
Cancer stemness-modulating circular RNAs in colorectal tumorigenesis: target proteins and regulatory mechanisms [0.03%]
结直肠肿瘤发生过程中调控癌干细胞发生的circRNA及其作用蛋白和机制研究
Chiu-Jung Huang,Kong Bung Choo
Chiu-Jung Huang
Cancer stem cells (CSCs), a small subpopulation of tumor cells with well-defined traits, play critical roles in tumorigenesis. Circular RNAs (circRNAs) have emerged as important regulators of cancer stemness and tumorigenesis. Applying stri...
Corrigendum to "Suppressing Cyclooxygenase-2 Prevents nonalcoholic and inhibits apoptosis of hepatocytes that are involved in the Akt/p53 signal pathway" [Biochem. Biophys. Res. Commun. 469 (2016) 1034-1040] [0.03%]
“抑制环氧化酶-2可预防非酒精性脂肪肝并抑制Akt/p53信号途径诱导的肝细胞凋亡”一文中“结果”部分图5和表2注释的勘误公告
Jialing Wu,Chong Chen,Xi Hu et al.
Jialing Wu et al.
In vitro investigation of miR-206-3p-loaded extracellular vesicles as modulators of Aβ-induced neurodegeneration [0.03%]
体外研究miR-206-3p负载的细胞外囊泡作为调节Aβ诱导神经退行性病变的调节因子
Sinan Gönüllü,Şeyma Aydın,Hamit Çelik et al.
Sinan Gönüllü et al.
In this study, we investigated the therapeutic potential of miR-206-3p delivered via small extracellular vesicles (sEVs) in an in vitro Alzheimer's disease model using SH-SY5Y human neuroblastoma cells treated with amyloid beta (Aβ). The s...
GALNT3-mediated AKT1 glycosylation activates the AKT1/CREB signaling pathway to inhibit high glucose-induced spermatogenic cell apoptosis and mitochondrial dysfunction [0.03%]
GALNT3介导的AKT1糖基化激活AKT1/CREB信号通路抑制高糖诱导的精原细胞凋亡和线粒体功能障碍
Yong Zhao,Jia Luo,Lu Wu
Yong Zhao
Diabetes-induced testicular damage (DITD) is a common complication of diabetes mellitus (DM), impairing spermatogenesis and contributing to male infertility, a condition associated with polypeptide N-acetylgalactoacyltransferase 3 (GALNT3),...