Kevin Gregory-Evans,Cheryl Y Gregory-Evans
Kevin Gregory-Evans
The fovea is an anatomic specialization of the human retina critical for high visual acuity, color vision, and contrast sensitivity. The molecular and cellular pathways directing this focal topography are still to be determined. Abnormaliti...
Review
Molecular vision. 2025 Oct 3:31:319-343. DOI: 2025
Dorota Wicher,Danuta Sielska-Rotblum,Urszula Zawadzka-Wiech et al.
Dorota Wicher et al.
Purpose: Retinoblastoma, the most common eye tumor in children, can occur in hereditary or nonhereditary forms. In the hereditary form, various germline alterations, single nucleotide (SNVs) or copy number variations (CNV...
Hyperosmolar stress induces monocyte chemoattractant protein 1 expression in retinal pigmented epithelial arising retinal pigmented epithelial 19 cells [0.03%]
Moncef Ould Hamou,Maureen Masset,Célia Weber et al.
Moncef Ould Hamou et al.
Purpose: Diabetes is a chronic inflammatory disease that may damage the blood-retinal barrier, leading to diabetic retinopathy (DR). Blood-retinal barrier rupture may subject the retinal pigmented epithelial cells to a hy...
Reticular fiber distribution in sclera: Key to understanding pathologic myopia and posterior staphylomas [0.03%]
Hirohiko Kakizaki,Heebae Ahn,Muhammad Abumanhal et al.
Hirohiko Kakizaki et al.
Purpose: To characterize the distribution of reticular fibers in the human sclera and explore their potential role in the pathogenesis of pathologic myopia and posterior staphyloma. ...
Macular white dot lesions with hyperreflective optical coherence tomography findings in cynomolgus and rhesus monkeys [0.03%]
crab锅岛正文白点状视网膜脉络膜病变的光学相干断层扫描特征
Tomoaki Araki,Masamitsu Shimazawa,Shinsuke Nakamura et al.
Tomoaki Araki et al.
Purpose: We screened 28 female cynomolgus monkeys (CMs) and 25 female rhesus monkeys (RMs) for white dots (WDs) in the macula and detected several animals with WDs in colonies at the Shin Nippon Biomedical Laboratories, L...
Bietti crystalline corneoretinal dystrophy: Advances in understanding and gene therapeutic approaches [0.03%]
Bietti结晶角膜视网膜 dystrophy：理解进展和基因治疗策略
Guangrong Zhao,Dayou Ding
Guangrong Zhao
Bietti crystalline dystrophy (BCD), an autosomal recessive inherited retinal disorder caused by mutations in the CYP4V2 gene, has long remained therapeutically challenging. Recent advances in adeno-associated virus-based gene therapy have e...
Review
Molecular vision. 2025 Sep 20:31:256-265. DOI: 2025
Unravelling γD-crystallin aggregation pathway to understand cataract formation using fluorescence correlation spectroscopy [0.03%]
运用荧光相关光谱解析γD-结晶蛋白聚集途径以阐释白内障的形成过程
Mangesh Bawankar,Bhaswati Sengupta,Sujata Malik et al.
Mangesh Bawankar et al.
Purpose: To characterize the aggregation behavior of the γD-crystallin protein in an acidic environment with a focus on the formation of intermediate species. The research employs fluorescence correlation spectroscopy to...
Mutations in retinal cyclic nucleotide-gated channels identified in familial cases of inherited retinal dystrophies from Pakistan [0.03%]
巴基斯坦遗传性视网膜变性家族病例中视网膜环核苷酸门控通道突变的鉴定
Zainab Akhtar,Kiran Afshan,Yumei Li et al.
Zainab Akhtar et al.
Purpose: Cyclic nucleotide-gated (CNG) channels are ligand-gated ion channels that transduce light signals into electrical signals in the retinal photoreceptors. Pathogenic variants in CNG channel genes are reported to ca...
Cysteinyl leukotriene receptor 1 regulates cellular glucose levels in human retinal cells [0.03%]
半胱氨酰白三烯受体1通过调节人视网膜细胞内的葡萄糖水平发挥作用
Andreas Koller,Susanne Maria Brunner,Julia Preishuber-Pflügl et al.
Andreas Koller et al.
Purpose: Cysteinyl leukotriene receptor 1 (CysLTR1), originally described as a proinflammatory G protein-coupled receptor, has been shown to possess diverse nonimmunological properties. One of these functions is to modula...
Phenotype-genotype correlation of patients with congenital cataracts and hair anomalies [0.03%]
先天性白内障和毛发异常患者的表型与基因型相关性分析
Qiwei Wang,Xiaoshan Lin,Dongni Wang et al.
Qiwei Wang et al.
Purpose: Hair anomalies represent a common associated symptom of congenital cataracts. Early diagnosis is crucial for treatment and predicting prognosis. However, the insidious and nonspecific nature of the symptoms in yo...