Macular white dot lesions with hyperreflective optical coherence tomography findings in cynomolgus and rhesus monkeys [0.03%]
crab锅岛正文白点状视网膜脉络膜病变的光学相干断层扫描特征
Tomoaki Araki,Masamitsu Shimazawa,Shinsuke Nakamura et al.
Tomoaki Araki et al.
Purpose: We screened 28 female cynomolgus monkeys (CMs) and 25 female rhesus monkeys (RMs) for white dots (WDs) in the macula and detected several animals with WDs in colonies at the Shin Nippon Biomedical Laboratories, L...
Bietti crystalline corneoretinal dystrophy: Advances in understanding and gene therapeutic approaches [0.03%]
Bietti结晶角膜视网膜 dystrophy：理解进展和基因治疗策略
Guangrong Zhao,Dayou Ding
Guangrong Zhao
Bietti crystalline dystrophy (BCD), an autosomal recessive inherited retinal disorder caused by mutations in the CYP4V2 gene, has long remained therapeutically challenging. Recent advances in adeno-associated virus-based gene therapy have e...
Review
Molecular vision. 2025 Sep 20:31:256-265. DOI: 2025
Unravelling γD-crystallin aggregation pathway to understand cataract formation using fluorescence correlation spectroscopy [0.03%]
运用荧光相关光谱解析γD-结晶蛋白聚集途径以阐释白内障的形成过程
Mangesh Bawankar,Bhaswati Sengupta,Sujata Malik et al.
Mangesh Bawankar et al.
Purpose: To characterize the aggregation behavior of the γD-crystallin protein in an acidic environment with a focus on the formation of intermediate species. The research employs fluorescence correlation spectroscopy to...
Mutations in retinal cyclic nucleotide-gated channels identified in familial cases of inherited retinal dystrophies from Pakistan [0.03%]
巴基斯坦遗传性视网膜变性家族病例中视网膜环核苷酸门控通道突变的鉴定
Zainab Akhtar,Kiran Afshan,Yumei Li et al.
Zainab Akhtar et al.
Purpose: Cyclic nucleotide-gated (CNG) channels are ligand-gated ion channels that transduce light signals into electrical signals in the retinal photoreceptors. Pathogenic variants in CNG channel genes are reported to ca...
Cysteinyl leukotriene receptor 1 regulates cellular glucose levels in human retinal cells [0.03%]
半胱氨酰白三烯受体1通过调节人视网膜细胞内的葡萄糖水平发挥作用
Andreas Koller,Susanne Maria Brunner,Julia Preishuber-Pflügl et al.
Andreas Koller et al.
Purpose: Cysteinyl leukotriene receptor 1 (CysLTR1), originally described as a proinflammatory G protein-coupled receptor, has been shown to possess diverse nonimmunological properties. One of these functions is to modula...
Phenotype-genotype correlation of patients with congenital cataracts and hair anomalies [0.03%]
先天性白内障和毛发异常患者的表型与基因型相关性分析
Qiwei Wang,Xiaoshan Lin,Dongni Wang et al.
Qiwei Wang et al.
Purpose: Hair anomalies represent a common associated symptom of congenital cataracts. Early diagnosis is crucial for treatment and predicting prognosis. However, the insidious and nonspecific nature of the symptoms in yo...
Mutation of beta-tubulin 4B gene (TUBB4B) causes autosomal dominant retinitis pigmentosa with sensorineural hearing loss in a multigenerational family [0.03%]
TUBB4B基因突变导致的常染色体显性视网膜色素变性和神经性耳聋家族病例研究报告
Cheryl Y Gregory-Evans,Aaron W Joe,Kevin Gregory-Evans
Cheryl Y Gregory-Evans
Purpose: Members of a multigenerational Canadian family presented to an inherited retinal degeneration (IRD) clinic with retinitis pigmentosa (RP) and sensorineural hearing loss, reminiscent of an Usher syndrome phenotype...
Inhibitory effects of ursolic acid on oxygen-induced mouse retinal neovascularization via intravitreal injection [0.03%]
熊果酸对氧诱导的小鼠视网膜新生血管化的抑制作用
Lu Yang,Fen Yang,Weiliang Zhang et al.
Lu Yang et al.
Objective: This study aimed to explore the effects and mechanisms of ursolic acid (UA) on oxygen-induced retinal neovascularization (RNV) in mice and its inhibitory effects on human retinal capillary endothelial cells (HRCECs) under high-gl...
Unravelling γD-crystallin aggregation pathway to understand cataract formation using fluorescence correlation spectroscopy [0.03%]
采用荧光相关光谱法研究γD-结晶蛋白聚集途径以理解白内障形成机制
Mangesh Bawankar,Bhaswati Sengupta,Sujata Malik et al.
Mangesh Bawankar et al.
Purpose: To characterize the aggregation behavior of the γD-crystallin protein in an acidic environment with a focus on the formation of intermediate species. The research employs fluorescence correlation spectroscopy to...