A ternary association of KRas, EphA2 and integrins controls PDAC cell behaviour [0.03%]
KRas、EphA2和整合素的三元结合体控制胰腺癌细胞行为反应
Mahak Fatima,Nasir Haider,Stuart A Cain et al.
Mahak Fatima et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, primarily because late detection, a lack of effective therapies and an abundant desmoplastic reaction result in elevated proliferation, invasion and immune evasion. ...
Selective recognition of mitochondrial acyl carrier protein by the regulatory protein LYRM2 [0.03%]
LYRM2调节蛋白对线粒体酰基载体蛋白的识别作用
Yixing Suo,James J La Clair,Michael D Burkart
Yixing Suo
Human mitochondrial fatty acid synthesis plays a central role in coordinating lipid metabolism with respiratory chain biogenesis through the central mitochondrial acyl carrier protein (mACP). Although several Leucine-Tyrosine-Arginine motif...
Molecular Mechanism of Fungal Effector PevD1-NRP Interaction and Discovery of a Small-Molecule Disruptor [0.03%]
锈菌效应蛋白PevD1与宿主未知受体互作的分子机制及小分子阻断剂发现
Xin Yang,Siyuan Tian,Chao Xu et al.
Xin Yang et al.
Verticillium wilt, caused by Verticillium dahliae, is a devastating vascular disease that severely affects cotton and other dicotyledonous crops worldwide. The fungal effector protein PevD1 promotes disease progression by interacting with t...
Fengwei Zheng,Michael E O&#x;Donnell,Huilin Li
Fengwei Zheng
DNA sliding clamps, including PCNA (proliferating cell nuclear antigen) and the 9-1-1 (RAD9-RAD1-HUS1 in humans) complex, are ring-shaped protein complexes that encircle DNA and serve as central interaction platforms in DNA replication, rep...
ATR-dependent phosphorylation of the histone acetyltransferase HBO1 suppresses chromatin binding and promotes replication stress responses [0.03%]
组蛋白乙酰转移酶HBO1的ATR依赖性磷酸化抑制染色质结合并促进复制压力反应
Chunyan Zong,Jiamin Zhang,Zhe Zhang et al.
Chunyan Zong et al.
Mounting evidence has shown that histone acetyltransferase binding to ORC1 (HBO1) serves as an oncoprotein, warranting the use of the small molecule inhibitor WM-3835 for cancer therapy. However, HBO1 is ubiquitously expressed in both tumor...
Crystal structure of a β1,3-Glucosyltransferase reveals an unusual substrate recognition by a two-domain GT-A fold glycosyltransferase [0.03%]
一个二结构域GT-A折叠糖基转移酶的晶体结构揭示了一种不同寻常的底物识别方式
Steven J Berardinelli,Renuka Kadirvelraj,Kelvin B Luther et al.
Steven J Berardinelli et al.
β1,3-Glucosyltransferase (B3GLCT) adds a glucose onto O-linked fucose on thrombospondin type 1 repeats (TSRs). Protein O-fucosyltransferase 2 (POFUT2) first transfers a fucose to properly folded TSRs containing a consensus sequence for O-f...
Lysine-374 Lactylation of TFRC Is Essential for TFRC-Mediated kidney Tubular Ferroptosis in Diabetic Kidney Disease [0.03%]
糖尿病肾病中TFRC介导的肾小管铁死亡需要TFRC赖氨酸374乳酸化
Xiaomai Liu,Runzhu Yuan,Wenya Zhu et al.
Xiaomai Liu et al.
Diabetic kidney disease (DKD), a leading cause of end-stage kidney disease, lactate overload and ferroptotic kidney injury, yet the mechanistic link between lactylation and ferroptosis remains undefined. Using lactylome profiling of db/db m...
Dynamic SOX2 Gene Expression Revealed by Phase-Separated Single RNA Imaging in Live Porcine Cells [0.03%]
活体猪细胞中由相分离介导的SOX2基因动态表达的单分子RNA成像研究
Chaoqian Jiang,Zhongyu Yuan,Chuanpei Li et al.
Chaoqian Jiang et al.
RNA plays a central role in the formation of diverse traits in pigs. Visualizing RNA dynamics at the single-molecule level in living cells is therefore essential for understanding gene-expression regulation in this species. We report an opt...
Activation of pro-survival autophagy by a small molecule promoting p62 oligomerisation [0.03%]
一种促进p62寡聚化的小分子激活生存自噬
Johan Panek,Edward Fielder,Congsing Sun et al.
Johan Panek et al.
Autophagy is a critical mechanism of cellular quality control, orchestrated by selective autophagy receptor (SAR) proteins. Pharmacologically enhancing the cargo-targeting capacity of SARs presents an attractive but underexplored strategy f...
E3 ligase RNF145 regulates airway smooth muscle cell proliferation via the PP2A-p70S6K signaling axis [0.03%]
E3连接酶RNF145通过PP2A-p70S6K信号轴调节气道平滑肌细胞增殖
Vijaya Kumar Gangipangi,Erin O Curley,Deepak A Deshpande et al.
Vijaya Kumar Gangipangi et al.
Airway smooth muscle (ASM) is a key determinant of airway caliber and a major contributor to structural remodeling in obstructive lung diseases, including asthma and COPD. ASM proliferation is regulated by transcriptional and post-transcrip...