The stress-activated kinase p38 mediates non-canonical activation of Src and tyrosine phosphorylation of the adapter protein TAB1 [0.03%]
应力激活激酶p38介导Src非经典活化及其底物衔接蛋白TAB1酪氨酸磷酸化
Iimi Onuma,Yusuke Iwata,Yue Zhou et al.
Iimi Onuma et al.
Src is a non-receptor tyrosine kinase that is overexpressed and highly activated in many cancers and is one of the key factors contributing to malignant transformation. According to current concepts, Src activity relies on tyrosine phosphor...
A new functional assay reveals that membrane binding is critical for overactivation of the phosphoinositide 3-kinase H1047R mutant [0.03%]
一种新的功能学测定法显示磷脂肌醇3-激酶H1047R突变体活化依赖于与细胞膜的结合
Alexandra Papafotika,Maria Pavlaki,Vasiliki Lazani et al.
Alexandra Papafotika et al.
PIK3CA encodes the catalytic subunit of class I PI3Kα (p110α), a key enzyme in receptor-mediated signaling that phosphorylates phosphatidylinositol-4,5-bisphosphate to the 3,4,5-triphosphate lipid. This gene is frequently mutated in cance...
Motif V is an allosteric couple between the SARS-CoV-2 nsp13 nucleotide triphosphatase and helicase active sites [0.03%]
冠状病毒解旋酶NTP酶和解旋酶活性位点之间的别构偶联关系
Michael A Mingroni,Brooke M Enney,Lauren E Malsick et al.
Michael A Mingroni et al.
Non-structural protein 13 (nsp13), the Coronaviral RNA helicase, is an attractive antiviral target due to its importance in viral genome replication and highly conserved nature. Nsp13's processive dsRNA unwinding is driven by ATP hydrolysis...
The terminal heme synthetic enzyme, Coproheme Decarboxylase, negatively regulates heme uptake in Mycobacterium tuberculosis [0.03%]
结核分枝杆菌中的终端血红素合成酶Coproheme Decarboxylase的负调控作用可抑制血红素摄取
Rebecca K Donegan,Yibo Fu,Jacqueline Copeland et al.
Rebecca K Donegan et al.
Heme is an essential cofactor and dietary source of iron for the obligate human pathogen, Mycobacterium tuberculosis (Mtb). Consequently, heme is required for Mtb growth and pathogenicity and strategies to limit heme represents a promising ...
Kathrine Tejlgård Jensen,Ana Viana Almeida,Sanne Rönning et al.
Kathrine Tejlgård Jensen et al.
Cluster of differentiation 109 (CD109) is a cell surface protein found on many human cell types, including keratinocytes, platelets, and T-cells. It is a protease inhibitor of the α-macroglobulin protein superfamily and is reported to affe...
Target validation uncouples mitochondrial translocator protein from 19-Atriol-mediated inhibition of steroidogenesis and identifies enzymatic targets [0.03%]
靶点确证将线粒体转运蛋白与19-阿特里奥尔介导的类固醇生成抑制作用脱钩，并确定了酶促靶标
Amy H Zhao,Prasanthi P Koganti,Mingxing Qian et al.
Amy H Zhao et al.
The mitochondrial translocator protein (TSPO) was once proposed to mediate mitochondrial cholesterol import for steroid hormone biosynthesis, but genetic deletion studies in multiple models have refuted this role. Nevertheless, the idea tha...
Long non-coding RNA LINC00607 epigenetically regulates endothelial TSPAN18 to promote hypoxia-induced thromboinflammation [0.03%]
长链非编码RNA LINC00607通过表观遗传调控内皮TSPAN18促进缺氧诱导的血栓炎症反应
Mohd Yasir Khan,Kashika Singh,Alia Hashmi et al.
Mohd Yasir Khan et al.
Hypoxia promotes endothelial dysfunction and thrombosis through transcriptional and epigenetic mechanisms that remain incompletely understood. Long non-coding RNAs have emerged as important regulators of endothelial gene expression, yet the...
Pex6 and ubiquitination regulate topological remodeling of the peroxisomal membrane protein Pex14 [0.03%]
Pex6和泛素化调节过氧化物酶体膜蛋白Pex14的拓扑重构
Takehiko Yasumitsu,Yuichi Yagita,Yukio Fujiki et al.
Takehiko Yasumitsu et al.
Pex14 is a membrane peroxin that plays a central role in matrix protein import by mediating the docking of the cytosolic receptor Pex5, which delivers cargo harboring a peroxisome targeting signal 1 (PTS1). We previously reported the crysta...
Nitric Oxide Mediates ET-1-induced-Inhibition of NPPB-Sensitive Cl- Currents in Early Distal Convoluted Tubule of the Mouse Kidney [0.03%]
一氧化氮介导内皮素-1对早期远曲小管氯离子电流的抑制作用
Lixia Hu,Hao Zhang,Ao Xiao et al.
Lixia Hu et al.
Endothelin-1 (ET-1) from renal-tubule-epithelial-cells inhibits NaCl reabsorption via ETB receptor in an autocrine manner and inhibition of ETB receptors leads to salt-sensitive-hypertension. In the distal-convoluted-tubule (DCT), NaCl ente...
The cytoplasmic protein YedX is a potent inhibitor of CsgA amyloid assembly in E. coli [0.03%]
YedX蛋白抑制大肠杆菌CsgA淀粉样纤维的形成
Bharat Gurnani,Neha Jain
Bharat Gurnani
Functional amyloids are a class of amyloids that serve important biological functions. One such bacterial functional amyloid is curli, assembled on the cell surface by Escherichia coli during biofilm biogenesis. Curli precursor proteins, Cs...