Identification of a conserved neutralizing epitope on the ASFV H240R protein by a nanobody that inhibits viral attachment [0.03%]
一种识别并抑制非洲猪瘟病毒H240R蛋白保守中和表位的纳米抗体
Dian Jiao,Binbin Ren,Dongying Liu et al.
Dian Jiao et al.
African swine fever virus (ASFV), a highly contagious double-stranded DNA virus, causes a hemorrhagic disease with mortality approaching 100% in domestic pigs. Despite intensive efforts, effective vaccine options remain limited, highlightin...
G protein-coupled receptor kinase 3 regulates CCR7 signaling, trafficking, and T cell responses to CCL19 and CCL21 [0.03%]
G蛋白偶联受体激酶3调控CCR7信号转导、转运及T细胞对CCL19和CCL21的反应
Anahi Sanchez,Cesar I Cardona,Brian Kaiser et al.
Anahi Sanchez et al.
G protein-coupled receptors (GPCRs) can bind multiple ligands leading to differential signaling events termed biased signaling. GPCR kinases (GRKs) can control the phosphorylation patterns of a GPCR to regulate biased signaling. Since the f...
James Q Zheng,Shuristeen Joubert,Carlos Gonzalez-Islas et al.
James Q Zheng et al.
The fascin family of actin-bundling proteins is best known for organizing actin filaments (F-actin) into tightly packed bundles that drive dynamic membrane protrusions such as filopodia. In neurons, fascin has been thought to primarily func...
Nanobody-based characterization of Galectin-13 reveals immunomodulatory and tumor-promoting functions [0.03%]
基于纳米抗体的半乳糖凝集素13表征揭示其免疫调节和促肿瘤功能
Camille Fuselier,Philippine Granger Joly de Boissel,Rita Nehmé et al.
Camille Fuselier et al.
Galectin-13 (GAL-13), also known as placental protein 13, is a lectin primarily studied in the context of pregnancy and immune regulation at the maternal-fetal interface. However, its potential roles in other tissues, including cancer, rema...
Integrated glycoproteomics reveals site-specific N-glycosylation defects in phosphomannomutase two congenital disorder of glycosylation [0.03%]
整合糖蛋白质组学揭示了岩藻糖转移酶缺乏型糖蛋白病变的位点特异性N-连接聚糖天冬酰胺连接糖基化缺陷
Jonas Nilsson,Ekaterina Mirgorodskaya,Carina Sihlbom Wallem et al.
Jonas Nilsson et al.
The routine diagnostic pathway for congenital disorders of glycosylation (CDG) relies on the analysis of carbohydrate-deficient transferrin in serum, a test that incompletely captures defects in N-linked glycosylation and may also yield fal...
Lingci Huang,Jun Zhang,Xinwei Wu et al.
Lingci Huang et al.
Embryonic stem cells (ESCs) are characterized by their dual capacity for self-renewal and differentiation into all cell types of the embryonic lineage. A subpopulation known as 2-cell-like cells (2CLCs), which recapitulate key molecular and...
Epistasis: Just say no! [0.03%]
表型遗传：拒绝就是了！
Natalie M Jaeger,Brennan A Fitzgerald,Michael J Harms
Natalie M Jaeger
Epistasis, where the effect of a mutation depends on other mutations, has been observed in virtually every quantitative biochemical feature examined. Despite its ubiquity, epistasis is often difficult to explain mechanistically. Its interpr...
The glycine N-methyltransferase amino-terminus regulates folate-dependent feedback inhibition and S-adenosylmethionine homeostasis [0.03%]
甘氨酸N-甲基转移酶氨基端通过调节依赖叶酸的反馈抑制作用调控S-腺苷甲硫氨酸稳态
Isaac Kraz,Oi Wei Mak,Subray Hegde et al.
Isaac Kraz et al.
Maintenance of S-adenosylmethionine (SAM) homeostasis is essential for methylation of biomolecules, nucleotide and polyamine synthesis, and redox balance. While all methyltransferases consume SAM, only a subset of highly tissue-specific met...
The crystal structure of the activin B:Fst288 complex and computational insights into the broad antagonistic activity and specificity of follistatin [0.03%]
活化素B:Fst288复合物的晶体结构及泛拮抗活性和特异性的计算研究
Lucija Hok,Ryan G Walker,James A Howard et al.
Lucija Hok et al.
Members of the transforming growth factor-β (TGF-β) family regulate essential biological processes, and their activity is tightly controlled by extracellular antagonists like follistatin 288 (Fst288). While Fst288 potently inhibits severa...
Denuded peptidoglycan oligosaccharides enable the biochemical investigation of bacterial cell wall recognition, modification, and degradation [0.03%]
脱辅酶肽聚糖寡糖可使细菌细胞壁的识别、修饰和降解生化研究成为可能
Benjamin G Emmanuel,Grace DelMistro,Alexander C Anderson et al.
Benjamin G Emmanuel et al.
Peptidoglycan (PG) is an essential component of the bacterial cell wall, providing mechanical strength and maintaining cell shape. It consists of glycan chains crosslinked by short peptide stems, resulting in a chemically heterogeneous macr...