Synthesis of N-heterocyclic amides based on (+)-camphoric acid and study of their antiviral activity and pharmacokinetics [0.03%]
基于(+)-樟脑酸的N-杂环酰胺合成及其抗病毒活性和药代动力学研究
O I Yarovaya,D V Baranova,A S Sokolova et al.
O I Yarovaya et al.
Efficient conditions for the synthesis of nitrogen-containing heterocyclic derivatives of (1R,3S)(+)-camphoric acid were selected. A series of heterocyclic compounds based on (+)-camphoric acid bearing pharmacophoric fragments was synthesiz...
E M Mukhin,K V Savateev,V L Rusinov
E M Mukhin
This review is focused on the synthetic strategies to heterocyclic C-nucleosides and covers the literature from 2011 to 2021. The main attention is paid to the following three approaches: the direct C-C coupling of a carbohydrate moiety wit...
T R Karpova,A V Lavrenov,E A Buluchevskii et al.
T R Karpova et al.
Light alkenes are among the main petrochemical intermediate products, the consumption of which is steadily growing. Using ethylene as an example, the possibilities of using polyfunctional heterogeneous catalysts for carrying out practically...
Complexation ability of tetrasulfosubstituted cobalt(II) phthalocyanine toward ORF3a protein of SARS-CoV-2 virus [0.03%]
四磺化钴(II)酞菁与SARS-CoV-2病毒ORF3a蛋白的配位能力研究
O I Koifman,V E Maizlish,M O Koifman et al.
O I Koifman et al.
Complex formation processes of tetrasulfosubstituted cobalt(II) phthalocyanine with ORF3a accessory protein of SARS-CoV-2 coronavirus were studied. The interaction of ORF3a protein with SARS-CoV-2 virus with tetrasulfosubstituted cobalt(II)...
Synthesis of non-symmetric N-benzylbispidinol amides and study of their inhibitory activity against the main protease of the SARS-CoV-2 virus [0.03%]
非对称N-苯基-N-联苯二胺酰胺的合成及其抑制SARS-CoV-2主要蛋白酶活性的研究
A I Dalinger,D S Baev,O I Yarovaya et al.
A I Dalinger et al.
Based on the data obtained by molecular modeling of the non-covalent interaction of non-symmetric N-benzylbispidin-9-ol amides with the active site of the main protease 3CLpro of the SARS-CoV-2 virus, a series of compounds was synthesized, ...
Synthesis of conjugates of (a R,7 S)-colchicine with monoterpenoids and investigation of their biological activity [0.03%]
(aR,7S)-秋水仙碱与单萜类化合物的连接物的合成及其生物活性研究
E S Shchegravina,S D Usova,D S Baev et al.
E S Shchegravina et al.
Conjugates of the natural alkaloid (aR,7S)-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the S...
Synthesis of water-soluble porphyrin with tyrosine fragments and study of its interaction with S-protein of SARS-CoV-2 [0.03%]
酪氨酸片段合成水溶性卟啉及其与SARS-CoV-2的S蛋白相互作用的研究
S A Syrbu,A S Semeikin,N Sh Lebedeva et al.
S A Syrbu et al.
The multistage purposeful synthesis of 5,15-bis(4'-l-N-tyrosinylamidophenyl)-10,20-bis(N-methylpyridin-3'-yl)porphine diiodide was carried out, and the optimum synthesis conditions were determined. 5,15-Bis(4'-nitrophenyl)-10,20-bis(pyridin...
O A Koroleva,Yu V Dutikova,A V Trubnikov et al.
O A Koroleva et al.
The PROTAC (PROteolysis TArgeting Chimera) technology is a method of targeting intracellular proteins previously considered undruggable. This technology utilizes the ubiquitin-proteasome system in cells to specifically degrade target protei...
E F Panarin,A I Fischer,N A Nesterova et al.
E F Panarin et al.
Radical polymerization was used to synthesize and characterize (co)polymers with sodium styrenesulfonate (NaSS), 4-methacryloylamidosalicylic acid (MASA), and N-vinylpyrrolidone, which have a low cytotoxicity and a high antiviral activity a...
4-Hydroxy-3-nitro-1,4-dihydrotriazolo[5,1- c][1,2,4]triazines: synthesis, antiviral activity, and electrochemical characteristics [0.03%]
4-羟基-3-硝基-1,4-二氢三氮唑并[5,1-c][1,2,4]三嗪：合成，抗病毒活性和电化学特性
R A Drokin,E A Fesenko,P N Mozharovskaia et al.
R A Drokin et al.
A new method for preparation of 4-hydroxy-3-nitro-1,4-dihydrotriazolo[5,1-c][1,2,4]-triazines using 1-nitro-2-morpholinoethylene and 3-diazo-1,2,4-triazoles is proposed. Antiviral activity against the Coxsackie B3 virus and electrochemical ...