Cigarette smoke-induced alterations in endothelial nitric oxide synthase phosphorylation: role of protein kinase C [0.03%]
蛋白质激酶C在烟草烟雾引起的一氧化氮合酶磷酸化改变中的作用研究
L Wagner,B Laczy,M Tamaskó et al.
L Wagner et al.
Endothelial nitric oxide synthase (eNOS) is regulated by phosphorylation of Ser(1177) and Thr(495), which affects NO bioavailability. Cigarette smoke disturbs the eNOS-cGMP-NO pathway and causes decreased NO production. Here the authors inv...
EP2306 and EP2302, two novel squalene synthase inhibitors, stimulate endothelial nitric oxide synthase expression in cultured endothelial cells [0.03%]
新型法尼基二磷酸芬酶抑制剂EP2306和EP2302能诱导培养的内皮细胞表达内皮型一氧化氮合酶
Anna Tavridou,George Megaritis,Angeliki P Kourounakis et al.
Anna Tavridou et al.
EP2306 and EP2302 are two novel squalene synthase inhibitors with hypolipidemic, antiatherosclerotic, and antioxidant properties. In the present study, the authors investigated their effect on the expression and activity of endothelial nitr...
Atorvastatin neutralizes the up-regulation of thrombospondin-1 induced by thrombin in human umbilical vein endothelial cells [0.03%]
阿托伐他汀逆转人脐静脉内皮细胞凝血酶诱导的血小板源性生长因子mRNA和蛋白表达升高
Vicenta Martínez-Sales,Virtudes Vila,Marcos Ferrando et al.
Vicenta Martínez-Sales et al.
Statins have been reported to affect blood vessel formation. Thrombospondin-1 (TSP-1) is a multifunctional protein that affects vasculature systems such as platelet activation, angiogenesis, and wound healing. This study was designed to inv...
Comparison of effects of epigallocatechin-3-gallate on hypoxia injury to human umbilical vein, RF/6A, and ECV304 cells induced by Na(2)S(2)O(4) [0.03%]
儿茶素对Na₂S₂O₄诱导人脐静脉、RF/6A及ECV304细胞低氧损伤的影响比较研究
Hai-ning Yu,Xiao-Li Ma,Jun-guo Yang et al.
Hai-ning Yu et al.
Hypoxia is related to the etiology of numerous pathological disease states, such as the formation of tumors or diverse retinopathies. Epigallocatechin-3-gallate (EGCG), a potent polyphenolic antioxidant and antiangiogenic compound found in ...
Endothelial connexin 37, connexin 40, and connexin 43 respond uniquely to substrate and shear stress [0.03%]
内皮细胞连接蛋白37、连接蛋白40和连接蛋白43对底物和剪切应力的反应各不相同
Tiffany L Johnson,Robert M Nerem
Tiffany L Johnson
Endothelial connexins have been linked to atherosclerosis and hypertension; however, little is know about their sensitivity to stimuli and individual functions. This study investigates the responses of endothelial connexin 37, connexin 40, ...
Yan Li,Yi Wang,Qian Li et al.
Yan Li et al.
Resistin, a novel adipokine, was recently suggested to be involved in the development of endothelial dysfunction. However, the mechanisms of how resistin works are still unknown. This study was performed to investigate the relationship betw...
Noninvasive assessment of endothelial activity in patients with peripheral arterial disease and cardiovascular risk factors [0.03%]
外周动脉疾病和心血管危险因素患者的非侵入性内皮功能评估
Arnost Fronek,Dominic G DiTomasso,Matthew Allison
Arnost Fronek
Microvascular endothelial activity (EA) after stimulation with iontophoretically administered acetylcholine was evaluated using laser Doppler fluxmetery (LDF) and calibrated photoplethysmography (c-PPG) in normal patients and patients with ...
Vascular remodeling and prothrombotic markers in subjects affected by familial combined hyperlipidemia and/or metabolic syndrome in primary prevention for cardiovascular disease [0.03%]
血管重塑和促凝血标志物在家族性合并高脂血症和/或代谢综合征患者中的一级预防心血管疾病中的作用
Arrigo F G Cicero,Giuseppe Derosa,Marco Manca et al.
Arrigo F G Cicero et al.
Recent evidences suggest that modulation of vascular structure by matrix metalloproteinases (MMPs) could be a main determinant of acute cardiovascular events in high-risk subjects. The authors consecutively selected 46 subjects affected by ...
Endothelial dysfunction in post-myocardial infarction patients with various expressions of risk factors [0.03%]
不同危险因素表达水平的急性心肌梗死患者内皮功能损伤特点
B Erzen,M Sabovic,M Sebestjen et al.
B Erzen et al.
It has not been established yet whether patients who suffer myocardial infaction (MI) in the absence of classic risk factors also have endothelial dysfunction (ED), as has been shown for patients with risk factors, and if so, to what extent...
Metalloproteinases in diabetics and nondiabetics during acute coronary syndromes and after 3 months [0.03%]
急性冠脉综合征患者发病时及起病三个月后金属蛋白酶的变化及其与糖尿病的关系
Giuseppe Derosa,Arrigo F G Cicero,Filippo Scalise et al.
Giuseppe Derosa et al.
The authors hypothesized that matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1, and TIMP-2 would be abnormal in acute coronary syndromes (ACS). Forty-six diabetic and 78 nondiabetic patients during ACS...