Cigarette smoke-induced alterations in endothelial nitric oxide synthase phosphorylation: role of protein kinase C
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Endothelial nitric oxide synthase (eNOS) is regulated by phosphorylation of Ser(1177) and Thr(495), which affects NO bioavailability. Cigarette smoke disturbs the eNOS-cGMP-NO pathway and causes decreased NO production. Here the authors investigated the acute ... ...
