A study on the cellular and cytotoxic effects of S and Se heterocycles on the myeloid leukemia cell line PLB-985 [0.03%]
含硫硒杂环化合物对髓系白血病细胞株PLB-985的细胞及细胞毒性作用研究
Niccole Auld,Krystal Flood,Tanay Kesharwani et al.
Niccole Auld et al.
This paper describes the synthesis of several halogenated S and Se heterocycles and tests their biological activity by measuring the effects on the myeloid leukemia cell line, PLB-985 cells. We report that select compounds exhibit significa...
New Chirally Modified Bisphosphonates for Synthesis of Individual Beta,Gamma-CHX-Deoxynucleotide Diastereomers [0.03%]
新型手性修饰双膦酸类化合物用于合成单个β,γ-CHX-脱氧核苷酸非对映异构体
Pouya Haratipour,Corinne Minard,Maryam Nakhjiri et al.
Pouya Haratipour et al.
Individual diastereomers of CXY bisphosphonate analogues of dNTPs or NTPs are useful chemical stereoprobes to investigate interactions within the chiral active site environment of enzymes such as polymerases and kinases. We previously repor...
Synthesis of ortho-Formylphenylphosphonic Acids as Covalent Probes of Active Site Lysines [0.03%]
合成邻甲醛苯基膦酸作为活性位点赖氨酸的共价探针
Marlon Vincent V Duro,Khadijeh S Alnajjar,Joann B Sweasy et al.
Marlon Vincent V Duro et al.
During the course of an investigation of targeted inhibition of DNA polymerase beta (pol β) lyase activity using small molecules, we observed the formation of an aldimine between (2-formyl)phenylphosphonic acid (2FPP) and butylamine under ...
NEW METHOD FOR THE SYNTHESIS OF AMMONIUM SALTS OF O,O'-ALKYLENEDITHIOPHOSPHORIC ACID AND OCTATHIOTETRAPHOSPHETANE. CRYSTAL STRUCTURE FEATURES'S OF DIETHYLAMMONIUM SALT OF O,O'-PROPYLENEDITHIOPHOSPHORIC ACID [0.03%]
O,O-亚烷基二硫代磷酸铵盐及八硫四磷杂环的新合成法及其1，2-丙烷二乙胺盐的晶体构造研究
Elena K Badeeva,Angelo Santomenna,Aidar T Gubaidullin et al.
Elena K Badeeva et al.
A new reaction of elemental phosphorus (P4) with elemental sulfur and 1,3-propylene glycol in the presence of different amines has been investigated. Ammonium salts of O,O'- alkylenedithiophosphoric acids have been observed as main products...
Zwitterionic Ligands Bound to CdSe/ZnS Quantum Dots Prevent Adhesion to Mammalian Cells [0.03%]
两性离子配体结合的CdSe/ZnS量子点可防止粘附于哺乳动物细胞表面
Ryan F Landis,Rui Tang,Singyuk Hou et al.
Ryan F Landis et al.
Zwitterionic materials are useful tools in material science and biology as they provide high water solubility while preventing non-specific interactions. Quantum dots (QDs) functionalized with zwitterionic and quaternary ammonium ligands we...
Synthesis and characterization of novel fluorescent nitrogen-containing bisphosphonate imaging probes for bone active drugs [0.03%]
新型氮杂茋含氮双膦酸骨活性药物影像探针的合成与表征研究
Shuting Sun,Katarzyna M Błażewska,Boris A Kashemirov et al.
Shuting Sun et al.
Progress in the synthesis of novel fluorescent conjugates of N-heterocyclic bisphosphonate drugs and related analogues, together with some recent applications of these compounds as imaging probes, are briefly discussed.
Synthesis and sensing of bisphosphonophosphate alkyl monoesters: A novel class of compounds for the study of nucleoside 5'-triphosphate chemistry [0.03%]
双瞵酸单酯的合成与识别：一类用于核苷5'-三磷酸研究的新化合物类
Brian T Chamberlain,Jorge Osuna,Boris A Kashemirov et al.
Brian T Chamberlain et al.
A series of novel β,γ-methylene-, monofluoromethylene-, and difluoromethylene-bisphosphonophosphate alkyl monoesters was synthesized. The compounds were conveniently detected during preparative HPLC using post-column derivatization with a...
Approaches to tyrosine-linked peptidomimetic prodrugs of (S)-HPMP-based acyclic nucleoside phosphonates [0.03%]
基于(S)-HPMP的无环核苷膦酸类酪氨酸连接肽类似前药的方法学研究
Valeria M Zakharova,Ivan S Krylov,Michaela Serpi et al.
Valeria M Zakharova et al.
Synthetic approaches to a new class of tyrosine-linked prodrugs of two 3-hydroxy-2-(phosphonomethoxypropyl) (HPMP) nucleotide analogues ((S)-HPMPC and (S)-HPMPA) are outlined.
Abdol R Hajipour,Majid Mostafavi,Arnold E Ruoho
Abdol R Hajipour
A green, straightforward and novel method for oxidation of thiols to the corresponding disulfides is reported using K(2)S(2)O(8) in the ionic liquid 1-butyl-3-methylimidazolium bromide [(bmim)Br] at 65-70 °C. The corresponding disulfides w...
ELEMENTAL SELENIUM GENERATED BY THE PHOTOBLEACHING OF SELENOMEROCYANINE PHOTOSENSITIZERS FORMS CONJUGATES WITH SERUM MACROMOLECULES THAT ARE TOXIC TO TUMOR CELLS [0.03%]
光漂白产生的硒化物与血清大分子结合形成肿瘤细胞毒性复合物
Fritz Sieber,Jean-Pierre Daziano,Wolfgang H H Günther et al.
Fritz Sieber et al.
Elemental selenium generated by the photobleaching of selenomerocyanine dyes forms conjugates with serum albumin and serum lipoproteins that are toxic to leukemia and selected solid tumor cells but well tolerated by normal CD34-positive hem...