Synthesis of ortho-Formylphenylphosphonic Acids as Covalent Probes of Active Site Lysines
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During the course of an investigation of targeted inhibition of DNA polymerase beta (pol β) lyase activity using small molecules, we observed the formation of an aldimine between (2-formyl)phenylphosphonic acid (2FPP) and butylamine under basic aqueous condit... ...
