Receptor-specific TRAIL as a means to achieve targeted elimination of activated hepatic stellate cells [0.03%]
一种受体特异的TRAIL用于实现活化HSCs的靶向清除
Mohammad Arabpour,Robbert H Cool,Klaas Nico Faber et al.
Mohammad Arabpour et al.
Activated hepatic stellate cells (HSCs) are known to play a central role in liver fibrosis and their elimination is a crucial step toward the resolution and reversion of liver fibrosis. Tumor necrosis factor-related apoptosis-inducing ligan...
Immunomodulation of cell-penetrating tat-metallothionein for successful outcome of xenotransplanted pancreatic islet [0.03%]
用于胰岛异种移植成功的穿膜tat-金属硫蛋白免疫调节研究
Min Jun Kim,Yong Hwa Hwang,Yong Hee Kim et al.
Min Jun Kim et al.
Pancreatic islet transplantation is a promising treatment for treatment of type 1 diabetes; however, transplantation outcomes have been disappointing due to early graft loss that is mediated by many immune responses. Immune cells not only d...
The effect of non-specific tight junction modulators on the transepithelial transport of poorly permeable drugs across airway epithelial cells [0.03%]
非特异性紧密连接调节剂对空气道上皮细胞中低渗透性药物经上皮转运的影响
Maliheh Ghadiri,Paul M Young,Wolfgang Jarolimek et al.
Maliheh Ghadiri et al.
The epithelial barrier in the respiratory system is a major obstacle for drug delivery to the systemic circulation in the lung. Epithelial barrier hinders the transport of large macromolecules or polar drugs. Essential components of this ep...
Nzungize Lambert,Abualgasim Elgaili Abdalla,Xiangke Duan et al.
Nzungize Lambert et al.
Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis, uses various tactics to resist on antibiotics and evade host immunity. To control tuberculosis, antibiotics with novel mechanisms of action are urgently need...
Trileucine residues in a ligand-CPP-based siRNA delivery platform improve endosomal escape of siRNA [0.03%]
基于配体-CPP的siRNA递送平台中的三亮氨酸残基可改善siRNA的溶酶体逃逸作用
Irfan Ullah,Kunho Chung,Jagadish Beloor et al.
Irfan Ullah et al.
siRNA entrapment within endosomes is a significant problem encountered with siRNA delivery platforms that co-opt receptor-mediated entry pathways. Attachment of a cell-penetrating peptide (CPP), such as nona-arginine (9R) to a cell receptor...
Co-delivery of curcumin and STAT3 siRNA using deformable cationic liposomes to treat skin cancer [0.03%]
利用可变形阳离子脂质体共递送姜黄素和STAT3 siRNA治疗皮肤癌
Anup Jose,Suman Labala,Venkata Vamsi Krishna Venuganti
Anup Jose
Skin cancer is one of the most widely prevalent cancer types with over expression of multiple oncogenic signaling molecules including STAT3. Curcumin is a natural compound with effective anti-cancer properties. The objective of this work wa...
Yuan Xie,Anqiang Wang,Jianzhen Lin et al.
Yuan Xie et al.
Monopolar spindle1 (Mps1, also known as TTK) is the core component of the spindle assembly checkpoint, which functions to ensure proper distribution of chromosomes to daughter cells. Mps1 is hardly detectable in normal organs except the tes...
Leila Rahbarnia,Safar Farajnia,Hossein Babaei et al.
Leila Rahbarnia et al.
Phage display technology as a selection-based system is an attractive method for evolution of new biological drugs. Unique ability of phage libraries for displaying proteins on bacteriophage surfaces enable them to make a major contribution...
IL-4Rα aptamer-liposome-CpG oligodeoxynucleotides suppress tumour growth by targeting the tumour microenvironment [0.03%]
靶向肿瘤微环境的IL-4Rα适体-脂质体-CpG寡脱氧核苷酸抑制肿瘤生长
Yu-Jie Liu,Xiao-Qian Dou,Fang Wang et al.
Yu-Jie Liu et al.
Tumour immunosuppressive microenvironments inhibit antigen-specific cellular responses and interfere with CpG-mediated immunotherapy. Overcoming tumour microenvironment (TME) immunosuppression is an important strategy for effective therapy....
Chimeric peptide-mediated siRNA transduction to inhibit HIV-1 infection [0.03%]
chimere肽介导的siRNA转染抑制HIV-1感染
Shalmali Bivalkar-Mehla,Rajeev Mehla,Ashok Chauhan
Shalmali Bivalkar-Mehla
Persistent human immunodeficiency virus 1 (HIV-1) infection provokes immune activation and depletes CD4+ lymphocytes, leading to acquired immunodeficiency syndrome. Uninterrupted administration of combination antiretroviral therapy (cART) i...