Amorphous calcium phosphate tagged benzimidazole derivative MR10 nanoconjugate mitigates corticosteroid induced secondary osteoporosis in vivo [0.03%]
无定形钙磷酸盐标记的苯并咪唑衍生物MR10纳米缀合物可减轻糖皮质激素引起的继发性骨质疏松症
Sanjay Gopi,S Prethiba,S Madesh et al.
Sanjay Gopi et al.
Corticosteroid-induced osteoporosis leads to accelerated bone loss with associated oxidative stress, necessitating novel targeted therapeutic approaches. This work evaluates the protective efficacy of Amorphous Calcium Phosphate-tagged Benz...
Polysaccharide-Coated mPEG-PLA Nanoparticles Enhance Thymoquinone Delivery and Therapeutic Efficacy against Colorectal Cancer [0.03%]
表面活性多糖的mPEG-PLA纳米颗粒增强化橘芹生物碱的递送和抗结直肠癌功效
Shaheer Hasan Khan,Hina Younus,Masood Alam Khan
Shaheer Hasan Khan
Colorectal cancer (CRC) remains a major therapeutic challenge due to systemic toxicity and poor tumor selectivity of conventional treatments. Thymoquinone (TQ), a natural anticancer compound, faces limited clinical utility because of poor s...
Fabrication of Crosslinker-Free Chitosan-HPMC Hydrogel for Implant Coating: A new Approach for the Treatment of Osteomyelitis [0.03%]
一种治疗骨髓炎的新方法：用于医疗器械表面防感染涂层的无交联剂壳聚糖-羟丙基甲基纤维素水凝胶的制备
Mohammad Zahraei,Elahe Aghazadeh,Farid Abedin Dorkoosh et al.
Mohammad Zahraei et al.
Treatment of osteomyelitis is challenging because the systemic circulation often cannot deliver sufficient concentrations of antibiotics directly to the site of infection. The aim of this study was to fabricate a crosslinker free hydrogel c...
Mizolastine-loaded Spanlastics for treatment of Atopic Dermatitis: Immunomodulatory approach for management of inflammation [0.03%]
用于治疗特应性皮炎的 Mizolastine 荷载 Spanlastics 的免疫调节抗炎方法
Marwa G Elnaggar,Aml I Mekkawy,Amira F Taha et al.
Marwa G Elnaggar et al.
Atopic dermatitis (AD) is the most widespread chronic inflammatory skin disease characterized by impaired skin barrier, higher immunoglobulin E (IgE)-mediated sensitization, and pronounced inflammatory and immune activity. In this study, mi...
Post-Surgery Healing Hydrogel Dressing with Anti-Metastatic Potential and Its Effects on Breast Cancer Cell Metastasis and Endoplasmic Reticulum Localization of Grp78 [0.03%]
一种具有防转移潜能的术后愈合水凝胶敷料及其对乳腺癌细胞转移和GRP78内质网定位的影响
Qin Ma,Tang Jin,Yingqi Dai
Qin Ma
Investigating the molecular mechanisms underlying metastasis is crucial for addressing metastatic breast cancer. Two common chemotherapy drugs, doxorubicin and paclitaxel, partially work by triggering the unfolded protein response (UPR), wi...
Dectin-1 Receptor-Targeted β-Glucan Microparticles as Dry Powder Inhalation System - A Novel Strategy to Improve Lung Pharmacokinetics of Rifampicin [0.03%]
以Dectin-1受体为靶向的β-葡萄糖微粒作为干粉吸入系统——一种改善利福平肺药代动力学的新策略
Hemali Savla,Pramod Gupta,Savita Kulkarni et al.
Hemali Savla et al.
Tuberculosis (TB) remains a global health concern due to complex and lengthy treatment, suboptimal drug concentrations in alveolar macrophages (AMs) and increasing drug resistance. This study investigates dectin-1 receptor-targeted dry powd...
Mupirocin-Nanoemulsion Infused Salicylic Acid Gel Utilizing Nigella sativa Oil for Treatment of Imiquimod-Induced Psoriasis in Mice [0.03%]
利用 nigella sativa 油注入莫匹罗星-纳米乳的水杨酸凝胶治疗小鼠咪喹莫德诱导的银屑病
Mohd Haider Abbas,Uzma Farooq,Ahsan Ali et al.
Mohd Haider Abbas et al.
Psoriasis is an autoimmune dermal disease characterized by inflammation that results in excessive keratinocyte proliferation. The current topical therapies struggle to penetrate the keratinized layer to reach the targeted area. A combinator...
Ivabradine, a hyperpolarization-activated channel blocker, attenuates mechanical, but not heat, hypersensitivity in hyperglycemic and normoglycemic rat models of diabetic neuropathy [0.03%]
伊伐布雷定，一种细胞膜超极化激活通道阻滞剂，可减轻高血糖和正常血糖模型糖尿病鼠的机械性痛觉异常但不减轻热痛觉异常
Deana Mohamed Elsayegh,Omar Tluli,Maram Elzayyat et al.
Deana Mohamed Elsayegh et al.
Diabetic peripheral neuropathic pain (DPNP) is a debilitating complication of longstanding type 1 (T1DM) and type 2 (T2DM) diabetes mellitus. DPNP patients experience mechanical and thermal pain hypersensitivity. Despite its clinical signif...
Use of methotrexate carried in lipid core nanoparticles in rats with endotoxemia: a possible new strategy for the treatment of the cardiac dysfunction in sepsis [0.03%]
载脂质核纳米粒甲氨蝶呤在内毒素血症大鼠中的应用：脓毒症心脏功能障碍治疗的可能新策略
Natalia de Menezes Lopes,Maria Carolina Guido,Priscila de Oliveira Carvalho et al.
Natalia de Menezes Lopes et al.
Cardiac dysfunction is a major cause of death in endotoxemia. Previously, we showed that methotrexate (MTX) carried in lipid-core nanoparticles (LDE) can modulate immune response and increase myocardial angiogenesis. The aim was to test the...
Alginate-Based Wound Dressings Loaded with Natural Essential Oils: Physicochemical Characterization and Antibacterial Performance [0.03%]
基于海藻酸盐的伤口敷料负载天然精油：理化性质及抗菌性能研究
Elif Hatice Gürkan,Özge İskender
Elif Hatice Gürkan
Bacterial infections are a major challenge in wound healing, increasing complications and delaying recovery. This study developed alginate-based composite films incorporating three essential oils-Hypericum perforatum (healing), Laurus nobil...