Gene delivery system of pDNA using the blood glycoprotein fetuin [0.03%]
利用血液糖蛋白fetuin递送质粒 DNA 的基因传递体系
Yukinobu Kodama,Hiroki Hanamura,Takahiro Muro et al.
Yukinobu Kodama et al.
Fetuin is a biocompatible plasma protein and strongly enhances phagocytosis of bacteria, DNA and apoptotic cells by peripheral blood cells such as monocytes, macrophages and dendritic cells. We developed a novel gene delivery system: ternar...
Tao Wang,Radhika Narayanaswamy,Huilan Ren et al.
Tao Wang et al.
Pancreatic cancer has been a life-threatening illness associated with high incidence and mortality rates. Paclitaxel (PCT) that causes mitotic arrest in cancer cells disrupting microtubule function is used for pancreatic cancer treatment. N...
Comparative Study
Journal of drug targeting. 2018 Jun-Jul;26(5-6):505-515. DOI:10.1080/1061186X.2017.1405424 2018
Myofibrillogenesis regulator 1 (MR-1): a potential therapeutic target for cancer and PNKD [0.03%]
肌原纤维生成调节因子1(MR-1):癌症和PNKD的潜在治疗靶点
Junxia Wang,Wuli Zhao,Hong Liu et al.
Junxia Wang et al.
Human myofibrillogenesis regulator 1 (MR-1) is a functional gene also known as paroxysmal nonkinesigenic dyskinesia (PNKD). It is localised on human chromosome 2q35 and three different isomers, MR-1L, MR-1M and MR-1S, are formed by alternat...
Vincristine-loaded hydroxyapatite nanoparticles as a potential delivery system for bone cancer therapy [0.03%]
载 vincristine 的羟基磷灰石纳米颗粒作为骨癌治疗递送系统的一种潜在方法
Ana Luiza Chaves Maia,Carolina de Aguiar Ferreira,André Luis Branco de Barros et al.
Ana Luiza Chaves Maia et al.
Despite advances in the development of new therapeutic agents and diagnostic imaging techniques, the 5-year survival of osteosarcoma, the most common type of bone cancer, remains practically unaltered for the last three decades at around 60...
Kıvılcım Öztürk-Atar,Hakan Eroğlu,Sema Çalış
Kıvılcım Öztürk-Atar
Developing a new drug molecule is not only time-consuming and expensive, but also mostly a failing process. However, improving bioavailability, targetability, efficacy or safety of old drugs could be more effective way to use them in clinic...
Thermosensitive hydrogels a versatile concept adapted to vaginal drug delivery [0.03%]
热敏水凝胶：一种应用于阴道给药的多功能概念体系
Sebastien Taurin,Aliyah A Almomen,Tatianna Pollak et al.
Sebastien Taurin et al.
Vaginal drug delivery represents an attractive strategy for local and systemic delivery of drugs otherwise poorly absorbed after oral administration. The rather dense vascular network, mucus permeability and the physiological phenomenon of ...
The role of chitosan on oral delivery of peptide-loaded nanoparticle formulation [0.03%]
壳聚糖在肽载纳米粒子给药体系中作用的研究
Chun Y Wong,Hani Al-Salami,Crispin R Dass
Chun Y Wong
Therapeutic peptides are conventionally administered via subcutaneous injection. Chitosan-based nanoparticles are gaining increased attention for their ability to serve as a carrier for oral delivery of peptides and vaccination. They offere...
Ankush Sharma,Amit K Goyal,Goutam Rath
Ankush Sharma
Metal nanoparticles (NPs) may have the potential to overcome problems related to conventional chemotherapy. Metal NPs reported to play a beneficial and powerful role in cancer therapy providing better targeting, gene silencing and drug deli...
Alendronate-loaded, biodegradable smart hydrogel: a promising injectable depot formulation for osteoporosis [0.03%]
用于骨质疏松症的阿仑膦酸盐载药、可生物降解智能水凝胶：一种有前景的长效注射制剂
Noha Nafee,Mariam Zewail,Nabila Boraie
Noha Nafee
Alendronate (ALN) is a BCS III bone resorption inhibitor, with very poor oral bioavailability. Our approach is to develop a minimally invasive thermogelling system for prolonged local delivery of ALN. For this, different chitosan-based ther...
Optimisation of chloroquine phosphate loaded nanostructured lipid carriers using Box-Behnken design and its antimalarial efficacy [0.03%]
用于负载氯磷酸奎宁的纳米结构脂质载体的实验设计优化及其抗疟活性研究
Uday Krishna Baruah,Kuppusamy Gowthamarajan,Vanka Ravisankar et al.
Uday Krishna Baruah et al.
Chloroquine was once the most widely used antimalarial for nearly eight decades for its safety, efficiency, stability, low cost and finally for its less toxic nature. But its use and efficacy got slowly decreased with the increase of chloro...