Alendronate-loaded, biodegradable smart hydrogel: a promising injectable depot formulation for osteoporosis
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Alendronate (ALN) is a BCS III bone resorption inhibitor, with very poor oral bioavailability. Our approach is to develop a minimally invasive thermogelling system for prolonged local delivery of ALN. For this, different chitosan-based thermogels were develope... ...
