Synergistic Antiba cterial and Antibiofilm Activity of N-acetylcysteine Combined with Niosomal Recombinant Lysostaphin against MRSA Staphylococcus aureus [0.03%]
N-乙酰半胱氨酸与尼奥斯omes重组lysostaphin联合对抗MRSA的协同抗菌和抗生物被膜活性
Hadis Sadri,Nader Shahrokhi,Mina Ebrahimi-Rad et al.
Hadis Sadri et al.
Wound infections significantly impair healing and often result in chronic wounds, burdening healthcare systems substantially. The principal pathogen in such infections is Staphylococcus aureus (S. aureus), which forms biofilms that resist h...
Nanotechnology-based PD-L1 siRNA codelivery systems for improving cancer immunotherapy [0.03%]
基于纳米技术的PD-L1 siRNA协同递送系统可提高癌症免疫疗法疗效
Naghmeh Jabarimani,Mohammad Saleh Sadeghi,Maryam Edalat et al.
Naghmeh Jabarimani et al.
Immune checkpoint blockade targeting the PD-1/PD-L1 (Programmed cell death protein 1/Programmed death-ligand 1) axis has transformed cancer therapy. However, antibodies non-specifically bind to PD-1 or PD-L1 on both malignant and normal cel...
Nanovesicles-Enabled Concurrent Delivery of Cyclosporine and Vitamin D for Topical Treatment of Psoriasis [0.03%]
用于银屑病局部治疗的纳米囊泡介导环孢素和维生素D联合递送疗法
Kailas Moravkar,Vishakha Ipar,Kalpesh R Patil et al.
Kailas Moravkar et al.
Psoriasis is a chronic autoimmune skin disease, mediated by T-cells, which affects the quality of life of patients. Cyclosporine (Cys-A) & Vitamin D (Vit D3) are crucial drugs used in the treatment of the disease. They are mainly administer...
Therapeutic effects of fluorescent gabapentin carbon quantum dots on pentylenetetrazol-induced seizures in rats [0.03%]
荧光卡马汀碳量子点对戊四唑致痫大鼠的治疗效应研究
Ayşe Özçetin,Hüseyin Koyuncu,Gamze Camlik et al.
Ayşe Özçetin et al.
We aimed to synthesize carbon quantum dots (CQDs) from the active molecule gabapentin (GBP) and to test their effects on pentylenetetrazol (PTZ)-induced seizures. Gabapentin CQDs (GBPCQDs) were successfully synthesized in a microwave reacto...
Multi-pathway therapeutics in colorectal cancer: Targeting EMT, CSCs, and non-apoptotic cell death for drug resistance reversal [0.03%]
逆转药物耐药性的结直肠癌多通路治疗：靶向EMT、CSC和非凋亡性细胞死亡
Jiegang Hu,Zhiwei Tang,Narasimha M Beeraka et al.
Jiegang Hu et al.
Colorectal cancer (CRC) is a leading global malignancy, with therapeutic outcomes hampered by chemoresistance from epithelial-mesenchymal transition (EMT), colorectal cancer stem cells (CR-CSCs), and apoptosis evasion. Evidence highlights t...
Targeting Osteoporosis: Rutin-Loaded Proniosomes and Their Role in OPG/RANKL Modulation in Ovariectomized Rats [0.03%]
靶向治疗骨质疏松： rutin载药前尼奥ソーム及其在卵巢切除大鼠中对OPG / RANKL调节的作用
Abeer Salama,Amira Mohamed Mohsen,Asmaa Badawy Darwish
Abeer Salama
The current study aimed to investigate effect of Rutin loaded proniosomes on ovariectomized female rats for the treatment of osteoporosis. Rutin-loaded proniosomes (Rutin-PNs) were developed using coacervation phase separation method. The d...
ICAM-1 Targeting of Nanocarriers in a Human Blood-Brain-Barrier-on-a-Chip Complements In Vivo Brain Delivery Observations [0.03%]
人血脑屏障芯片中的纳米载体ICAM-1靶向互补体内脑递送观测结果
Marco Vigo,Sujey Palma-Florez,Rita Grimalt et al.
Marco Vigo et al.
Targeting therapeutic nanocarriers (NCs) to endothelial receptors favors transport across the blood-brain barrier (BBB), a main obstacle to access the brain. While these strategies compel validation in animals, quantitative sub-cellular res...
Mitigating Doxorubicin-Induced Toxicity in Breast Cancer Treatment with In Situ pH-Sensitive Carvedilol-loaded Transbilosomes: In Vitro and In Vivo Characterization [0.03%]
通过原位pH响应的Transbiosome递送卡维地洛减轻乳腺癌治疗中的多柔比星毒性：体外及体内研究
Tamer Mohamed Mahmoud,Mohammed Ayad Alboreadi,Fatma I Abo El-Ela et al.
Tamer Mohamed Mahmoud et al.
Doxorubicin (DRC) is widely used as a breast cancer treatment. However, its use is limited due to cardio, hepatic, and renal toxicities. Carvedilol (CVL) has emerged as a potential protective agent against DRC-induced toxicity (DIT). Despit...
Eco-Friendly Synthesis of Novel Enaminonitrile Pyridine Derivatives: 131I-Radiosynthesis, Anticancer Investigation and In-Vivo Study in Tumour Bearing Mice [0.03%]
新型烯胺腈吡啶衍生物的绿色合成：131I标记放射合成、抗肿瘤研究及荷瘤小鼠体内实验
Adli A Selim,Basma M Essa,Safaa S Shaban et al.
Adli A Selim et al.
Purpose: This study aimed to develop sustainable synthetic routes for novel enaminonitrile pyridine derivatives and evaluate a lead compound's potential as a dual-action theranostic agent for oncology, combining targeted ...
Exploring Chitosan/Clay Microparticles Enriched with Fenugreek Extract as a Potential Treatment Strategy for Infectious Diarrhea: Preclinical Investigation [0.03%]
富含香菜提取物的壳聚糖/粘土微粒作为感染性腹泻潜在治疗策略的临床前研究探索
Yan Cheng
Yan Cheng
The objective of this study was to develop a new delivery system, Fenugreek extract loaded into chitosan/clay particles, to treat bacterial diarrhea in a rat model. Microstructure studies, cell viability assay, release assay, antibacterial ...