Anti-GPC3 antibody and cell-penetrating peptide CPP44 dual-ligand modified liposomes for targeted delivery of arsenic trioxide in the treatment of hepatocellular carcinoma [0.03%]
抗GPC3抗体和细胞穿透肽CPP44双配体修饰的三氧化二砷脂质体用于肝癌治疗中的靶向递送
Congcong Lin,Jiamin Sun,Yun Yang et al.
Congcong Lin et al.
Arsenic trioxide (ATO), the active ingredient in Chinese arsenic, effectively inhibits hepatocellular carcinoma (HCC) cell growth, but its clinical application is limited by the lack of a targeted delivery system. Phosphatidylinositol prote...
Molecular and therapeutic insight into ER Stress signaling in NSCLC [0.03%]
非小细胞肺癌中内质网应激信号通路的分子机制及干预策略研究进展
Aastha Jadhav,Arjun Menon,Kush Gupta et al.
Aastha Jadhav et al.
Endoplasmic Reticulum (ER) stress is intricately involved in cancer development, progression and response to chemotherapy. ER stress related genes might play an important role in predicting the prognosis in lung adenocarcinoma patients and ...
The role of green synthesis metal and metal oxide nanoparticles in oral cancer therapy: a review [0.03%]
绿色合成金属及金属氧化物纳米颗粒在口腔癌治疗中的作用：综述
Songlin Zhou,Yutao Qin,Anwen Lei et al.
Songlin Zhou et al.
There are 275,000 new cases of oral cancer (OC) per year, making it the sixth most common cancer in the world. Severe adverse effects, including loss of function, deformity, and systemic toxicity, are familiar with traditional therapies suc...
Yuanyuan Li,Baojie Du,Lichao Yu et al.
Yuanyuan Li et al.
The cytosolic delivery of therapeutic proteins represents a promising strategy for addressing diseases caused by protein dysfunction. Despite significant advances, efficient delivery remains challenging due to barriers such as cell membrane...
Formulation, Optimization, and Evaluation of Lornoxicam-Loaded Novasomes for Targeted Ulcerative Colitis Therapy: In Vitro and In Vivo Investigations [0.03%]
用于靶向溃疡性结肠炎治疗的洛尼昔康载NovaSome的制备、优化及评价：体内外研究
Asmaa Badawy Darwish,Abeer Salama,Inas Essam Ibrahim Al-Samadi
Asmaa Badawy Darwish
The purpose of this work was to create and assess Lornoxicam (LOR) loaded Novasomes (Novas) for the efficient treatment of ulcerative colitis. The study was performed using a 23 factorial design to investigate the impact of several formulat...
Interactions and communications in lung tumor microenvironment: Chemo/radiotherapy resistance mechanisms and therapeutic targets [0.03%]
肺癌肿瘤微环境中的交互作用与通讯：耐药机制和治疗靶标
Yuan Feng,Ying Jiang,Lin Yang et al.
Yuan Feng et al.
The lung tumor microenvironment is composed of various cell types, including cancer cells, stromal and immune cells, as well as extracellular matrix (ECM). These cells and surrounding ECM create a stiff, hypoxic, acidic, and immunosuppressi...
Epidermal Growth Factor Receptors Unveiled: A Comprehensive Survey on Mutations, Clinical Insights of Global Inhibitors, and Emergence of Heterocyclic Derivatives as EGFR Inhibitors [0.03%]
表皮生长因子受体揭秘：全球抑制剂的突变、临床见解及杂环衍生物作为EGFR抑制剂的出现综述
Manojmouli C,T Y Pasha,Mohamed Rahamathulla et al.
Manojmouli C et al.
Mutations that overexpress the epidermal growth factor receptor (EGFR) are linked to cancers like breast (15-20%), head and neck (10-15%), colorectal (5-8%), and non-small cell lung cancer (10-50%), especially in East Asian populations. EGF...
Advancements in Colorectal Cancer Immunotherapy: From CAR-T Cells to Exosome-Based Therapies [0.03%]
结直肠癌免疫治疗进展：从CAR-T细胞治疗到外泌体治疗
Sepideh Arabi,Manouchehr Fadaee,Tohid Kazemi et al.
Sepideh Arabi et al.
Colorectal cancer (CRC) continues to be a major worldwide health issue, with elevated death rates linked to late stages of the illness. Immunotherapy has made significant progress in developing effective techniques to improve the immune sys...
Enhanced pharmacokinetic approach for anastrozole in macromolecule-based silk fibroin nanoparticles incorporated in situ injectables for estrogen-positive breast cancer therapy [0.03%]
一种基于大分子的丝素蛋白纳米颗粒增强瑞宁得药代动力学性质并用于雌激素受体阳性乳腺癌治疗的原位注射疗法
Arfa Nasrine,Sourav Mohanto,Soumya Narayana et al.
Arfa Nasrine et al.
Breast cancer (BC) is a substantial reason for cancer-related mortality among women across the globe. Anastrozole (ANS) is an effective orally administered hormonal therapy for estrogen+ (ER+) BC treatment. However, several side effects and...
Thomas Foster,Patrick Lim,Susbin Raj Wagle et al.
Thomas Foster et al.
Vision loss and blindness are significant issues in both developed and developing countries. There are a wide variety of aetiologies that can cause vision loss, which are outlined in this review. Although treatment has significantly improve...