Emerging trends in viral infection inhibition using a chitosan-based drug delivery system [0.03%]
基于壳聚糖的药物递送系统在病毒感染抑制中的新兴趋势研究进展
Somayeh Kakehbaraei,Morteza Arab-Zozani,Seyran Kakebaraei
Somayeh Kakehbaraei
Viral diseases damage the host's cells and weaken the host's immunity, leading to multiple relapses or lasting a long time. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a prevalent infection that can cause immunostimu...
Protein Biomarker Modulation and Wound Healing Efficacy of Mentha piperita-Based Green-Synthesized Silver Nanoparticles in Alloxan-Induced Diabetic Rats [0.03%]
薄荷素油基绿色合成的银纳米颗粒在糖尿病大鼠创面修复中的蛋白生物标志物调控及伤口愈合效果研究
Reema Aftab,Amber Afroz,Muhammad Irfan et al.
Reema Aftab et al.
The stability of Mentha piperita-silver nanoparticles (MPAgNPs), their hydrodynamic size, and expression of potential biomarkers in diabetic rat wounds, pre- and post-healing, were studied in vivo. State-of-the-art analytical techniques wer...
The enhanced surface permeability and retention effect of topically administrated nanoparticles [0.03%]
表用纳米颗粒的增强表面渗透性及滞留效应
Yiyang Chen,Zhenghong Liu,Bin Zheng et al.
Yiyang Chen et al.
Topical administration provides direct way for nanoparticles (NPs) to reach the tumor surface, inducing a more localized and direct therapeutic effect than what intravenous therapy can do and meanwhile guaranteeing higher biosafety. By leve...
Small Extracellular Vesicles-Based Drug Delivery Systems for Therapies of Gastrointestinal Tumors [0.03%]
基于小细胞外囊泡的胃肠肿瘤治疗药物递送系统
Lan Luo,Dongli Wang,Wenrong Xu et al.
Lan Luo et al.
Gastrointestinal tumors pose a significant threat to human health. Small extracellular vesicles (sEVs) have emerged as a promising approach for drug delivery in the treatment of gastrointestinal tumors. sEVs exhibit intrinsic advantages ove...
Development and Characterization of Ag-NPs Coated Silk Sutures: A Novel Approach to Inhibit Surgical Site Infections [0.03%]
一种新型抗菌缝线的开发及其性能表征：涂有Ag-NPs丝线缝合线抑制手术部位感染的新方法
Sunirmal Bhattacharjee,Debjani Sarkar,Richa Dayaramani et al.
Sunirmal Bhattacharjee et al.
Sutures play an essential role in surgical operations, as they secure and stabilize the edges of wounds to facilitate healing. Nonetheless, microbes on sutures can heighten the likelihood of surgical site infections (SSI) because of pathoge...
Bipartite 5-fluorouracil and lepidine-based nanoemulsion gel: in vitro and dermatokinetic evaluation [0.03%]
基于双二分法5-氟尿嘧啶和氯化丁子香酚的纳米乳凝胶：体外及透皮吸收评价
Zeba Usmani,Samreen Jahan,Zakiya Usmani et al.
Zeba Usmani et al.
Skin cancer is the most prevalent malignancy, with rising incidence and morbidity, particularly among the white population. This study aims to develop a dual drug-loaded nanoemulsion gel incorporating 5-fluorouracil (5-FU) and lepidine (LPD...
Dual AMPK Activation and TXNIP Suppression Underlie the Superior Anti-Diabetic Action of Rosiglitazone-Metformin Co-Crystal (RZM): Evidence from Preclinical Models [0.03%]
罗格列酮二甲双胍共晶通过双重AMPK激活和TXNIP抑制产生优异的降糖作用：来自临床前模型的证据
Leping Ruan,Yi Song,Gang Wang et al.
Leping Ruan et al.
This study investigates the anti-diabetic potential of rosiglitazone-metformin adduct (RZM), a 1:1 molar co-crystal complex, in spontaneous diabetic KK mice and streptozotocin-induced diabetic rats. Diabetic models were divided into four gr...
Therapeutic liposomes synergize with active molecules to enhance targeted therapy [0.03%]
治疗脂质体与活性分子协同作用以增强靶向治疗效果
Alireza Partoazar,Ramin Goudarzi,Ahmad Reza Dehpour
Alireza Partoazar
Liposomes composed of phospholipids (PLs) either alone or with an active molecule, can reveal a significant potential in the improvement of severe disorders such as Alzheimer's disease, osteoporosis, and inflammatory conditions. For instanc...
Efficacy of intranasal delivery of VEGFR inhibitors to cervical lymph nodes for inhibiting tongue cancer metastasis in mice [0.03%]
鼻内给药抑制小鼠舌癌淋巴转移的效果及机制研究
Tomoyuki Furubayashi,Minori Kobayashi,Nao Hamada et al.
Tomoyuki Furubayashi et al.
Oral cancers frequently metastasize to adjacent cervical lymph nodes (CLNs), leading to systemic dissemination and poor prognosis. Intranasal drug delivery provides direct access to cervical lymphatics, enabling high local drug concentratio...
The Golgi Apparatus as a Strategic Target in Cancer: Mechanisms, Diagnosis and Therapeutic Opportunities [0.03%]
戈尔吉 apparatus 在癌症中的战略靶点作用：机制、诊断和治疗机会
Chao Cui,Chenglu Sun,Peng Yuan et al.
Chao Cui et al.
The Golgi apparatus, a central hub for protein processing and transportation, plays a critical role in cancer progression and has thus emerged as a highly promising therapeutic target. This review discusses the molecular mechanisms underlyi...