Dual AMPK Activation and TXNIP Suppression Underlie the Superior Anti-Diabetic Action of Rosiglitazone-Metformin Co-Crystal (RZM): Evidence from Preclinical Models
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This study investigates the anti-diabetic potential of rosiglitazone-metformin adduct (RZM), a 1:1 molar co-crystal complex, in spontaneous diabetic KK mice and streptozotocin-induced diabetic rats. Diabetic models were divided into four groups: vehicle contro... ...
