Redox responsive functionalised mesoporous silica nanoparticle for targeted drug delivery of doxorubicin [0.03%]
一种还原响应的功能化介孔硅纳米粒子用于盐酸多柔比星靶向输送
Seyedeh Sahar Mojtabazadeh,Mahnoosh Samadi,Sahra Perseh et al.
Seyedeh Sahar Mojtabazadeh et al.
Mesoporous silica nanoparticles (MSNs) have been studied for the delivery of anticancer drugs because of their unique mesoporous channels. In this study, Biotin was used as a targeting moiety of MSNs for the purpose of breast cancer cell ta...
Nanotechnology-driven approaches for the early detection and targeted treatment of Alzheimer's disease [0.03%]
纳米技术在阿尔茨海默病早期检测和靶向治疗中的应用
Dinesh Kumar Sharma
Dinesh Kumar Sharma
A neurodegenerative condition called Alzheimer's disease (AD) is brought on by the buildup of beta-amyloid plaques in the brain. As of right now, AD has no known cure. The only thing the medications on the market can do is slow their develo...
pH-targeted and time-released microparticles of quercetin and lycopene for ulcerative colitis treatment: DoE-based formulation development, pharmacokinetics, and in-vivo proof of concept studies [0.03%]
针对溃疡性结肠炎治疗的基于DoE的花青素和番茄红素pH值定位及缓释微粒制剂的研发、药代动力学及概念验证实验研究
Syaiful Choiri,Nadia Risti Ikka Pertiwi,Diva Amanda Nur Saputri et al.
Syaiful Choiri et al.
Lycopene (LYC) and quercetin (QRN) exhibit synergistic effects on ulcerative colitis (UC) treatment due to their anti-inflammatory and antioxidant properties. This study aimed to develop a microparticle formulation utilizing pH-sensitive an...
Ethosome-Based Delivery of Betanin and Curcumin for Improved Anti-Inflammatory Efficacy [0.03%]
基于乙osomes的花青素和姜黄素递送以提高抗炎功效
Sangameshwar Kanthale,Vaibhav Bharad,Prakash Kendre et al.
Sangameshwar Kanthale et al.
Natural phytoconstituents such as betanin and curcumin have attracted interest for their significant antioxidant and anti-inflammatory properties. Their therapeutic efficacy is notably constrained by inadequate bioavailability and reduced s...
Curcumin Liposomal Nanoparticles Provide Superior Neuroprotection by Attenuating Neuropathic Pain, Neuroinflammation, and Anxiety in Chronic Sciatic Nerve Injury in rats [0.03%]
姜黄素脂质纳米颗粒通过减轻慢性坐骨神经损伤大鼠的神经病理性疼痛，神经炎症和焦虑提供更好的神经保护作用
Mohammad Ebrahim Abbaszadeh,Gila Pirzad Jahromi,Bohlol Habibi Asl et al.
Mohammad Ebrahim Abbaszadeh et al.
Background: Chronic constriction injury (CCI) of the sciatic nerve induces neuropathic pain, inflammation, oxidative stress, and neurodegenerative changes, impairing sensory and emotional function. While curcumin is well ...
"Engineering Rifampicin-Encapsulated Inhalable Microparticles for Precision Tuberculosis Therapy: In Vivo Distribution and Therapeutic Evaluation" [0.03%]
“用于精准结核病治疗的利福平缓释微粒吸入剂的在体分布及疗效研究”
Ruchi Tiwari,Patibandla Jahnavi,Dhakshnamoorthy Vellingiri et al.
Ruchi Tiwari et al.
Tuberculosis (TB) continues to cause significant global mortality, highlighting the need for improved drug delivery systems. The objective of this paper focuses in describing the formulation, optimization and in vivo assessment of rifampici...
L-Carnosine Loaded Chondroitin Sulphate Functionalized Proposomes as an Effective Tool for Transdermal Rheumatoid Arthritis Management [0.03%]
硫酸软骨素功能化载L-半胱氨酰谷胺酸二元醇胶束作为有效的类风湿关节炎经皮治疗手段
Mariam Zewail,Haidy Abbas,HussamElDin Y Aboukilila et al.
Mariam Zewail et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes joint inflammation, cartilage deterioration, and oxidative stress. The study developed transdermal RA treatment with L-carnosine (CAR)-loaded chondroitin sulfate (CHS) fu...
Human plasma-derived exosomal gel: a biomimetic cargo for the transdermal delivery of methotrexate [0.03%]
人血浆源性外泌体凝胶：甲氨蝶呤经皮给药的仿生载体
Rabia Gul,Wajeeha Khalid,Muhammad Sarfraz et al.
Rabia Gul et al.
The aim of the study was to explore the potential of human plasma-derived exosomal gel as a carrier for transdermal drug delivery. Exosomes were isolated from human plasma through a combination of ultracentrifugation and dialysis techniques...
Mannosylated chitosan-decorated PLGA nanoparticles for targeted pulmonary delivery of Isoniazid: A promising approach in the treatment of Tuberculosis [0.03%]
N-乙酰氨基葡萄糖修饰的壳聚糖包被的PLGA纳米颗粒用于异烟肼的肺部靶向给药：在结核病治疗中的潜在应用
Riffat Maqbool,DurE Nayab,Muhammad Mubeen et al.
Riffat Maqbool et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb), represents a significant challenge to global health. The management of the disease requires an extended course of antibiotic therapy, spanning a duration of 6 to 9 months. The...
Bioengineered nanocomposite bacitracin zinc-loaded chitosan microspheres containing keratin/gelatin films for wound healing [0.03%]
用于伤口愈合的角蛋白/明胶薄膜包覆的多粘菌素锌盐壳聚糖微球生物纳米复合材料
Payal Shetty,Marina Koland,Suprit D Saoji et al.
Payal Shetty et al.
This work sought to create and describe a new antibiotic-loaded keratin-based film bandage to accelerate wound healing. Using the solvent casting technique, keratin-derived from chicken feathers, was used in different ratios to create films...