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pH-targeted and time-released microparticles of quercetin and lycopene for ulcerative colitis treatment: DoE-based formulation development, pharmacokinetics, and in-vivo proof of concept studies

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Lycopene (LYC) and quercetin (QRN) exhibit synergistic effects on ulcerative colitis (UC) treatment due to their anti-inflammatory and antioxidant properties. This study aimed to develop a microparticle formulation utilizing pH-sensitive and time-release-based... ...