Role of soluble EGFR, Fas, and Fas ligand in pelvic pain severity and their association with endometriosis in infertile woman: a case-control study [0.03%]
可溶性EGFR、Fas和Fas配体在盆腔痛严重程度的作用及其与不孕症妇女子宫内膜异位症的关系：一项病例对照研究
Fadhil Ahsan,Nanda Yuli Rahmawati,Fidyah Nanda Alditia et al.
Fadhil Ahsan et al.
Endometriosis, a chronic inflammatory condition linked to pelvic pain and infertility, is characterized by immune dysfunction involving dysregulated apoptosis and cell proliferation. This case-control study included 87 infertile women under...
ErbB receptor stimulation is required for mouse Colon adenoma organoids to form crypts [0.03%]
ErbB受体刺激是小鼠结肠腺瘤类器官形成隐窝所必需的条件
Chin Wee Tan,Ruiyan Zhu,Serena R Kane et al.
Chin Wee Tan et al.
When cultured with Wnt, R-spondin, EGF, Noggin, myofibroblast conditioned medium and Matrigel, crypts from normal mouse colon mucosa form crypt-producing organoids and can be passaged every seven days. Under the same culture and passage con...
Chorioallantoic membrane assay demonstrating pro-angiogenic properties of BRAF inhibitor: a tool to treat chronic wounds [0.03%]
BRAF抑制剂促血管生成性质的卵黄囊膜实验测定：治疗慢性伤口的一种手段
Sonali Karhana,Yasmin Sultana,Nilanjan Saha et al.
Sonali Karhana et al.
The aim of the study was to evaluate the angiogenic potential and safety of Dabrafenib, a BRAF inhibitor, for wound healing applications using the chick embryo Chorioallantoic Membrane (CAM) assay. Fertilized chicken eggs were incubated, an...
Extracellular matrix biomarkers and transforming growth factor-β in hypertrophic cardiomyopathy: interaction between biomarkers [0.03%]
肥厚型心肌病的细胞外基质生物标志物及转化生长因子-β相互作用研究
Nesrine Fourti,Manel Ben Halima,Wiem Zidi et al.
Nesrine Fourti et al.
Significant dysregulation of matrix metalloproteinase (MMPs), their tissue inhibitors (TIMPs) and profibrotic cytokines have been reported in hypertrophic cardiomyopathy (HCM) and associated with adverse cardiac remodeling. We aim to invest...
Growth factors loaded chitosan scaffolds as bioactive biomimetic multifunctional platforms in periodontal tissue engineering: a review [0.03%]
负载生长因子的壳聚糖支架作为牙周组织工程中的生物活性仿生多功能平台：综述
Mohammed Alkandari,Meshari Alkandari,Gamal Abdel Nasser Atia et al.
Mohammed Alkandari et al.
Periodontitis causes severe tissue loss, making predictable regeneration a major challenge. Growth factor-loaded chitosan scaffolds offer a promising, multifunctional approach to enhance tissue regeneration. This review explores their desig...
Functional characterization of a clinically significant variant of IGF1R (M1054I) - a critical residue involved in defining the binding of small molecules in the allosteric pocket of IGF1R [0.03%]
IGF1R（M1054I）临床显著变异的功能表征——定义IGF1R的小分子结合的变构袋的关键残基
Farheen Showket,Aubaidah Akhtar,Sabra Parveen et al.
Farheen Showket et al.
IGF1R, a receptor tyrosine kinase, is crucial for cell growth, proliferation, and differentiation. Overexpression of IGF1R is linked to cancer and resistance to therapies, making it a target for drug development. Previously, we identified a...
DNA methyltransferase 1-mediated methylation of midkine regulate myocardial ischemia-reperfusion injury via the Notch2/Hes1 axis [0.03%]
DNA甲基转移酶1介导的.midkine甲基化通过Notch2/Hes1轴调节心肌缺血再灌注损伤
Wei Liu,Yuqin Wang,Jiayuan Wu et al.
Wei Liu et al.
myocardial ischemia-reperfusion injury (MI/RI) threatens people's lives. Midkine (MDK) has a protective effect against MI/RI. DNA methyltransferase 1 (DNMT1) is closely associated with MI/RI. Mouse cardiomyocytes were isolated to establish ...
Mendelian randomization analyses explore the causal relationship between fibroblast growth factor receptors and hypertrophic scar [0.03%]
孟德尔随机化分析探讨成纤维细胞生长因子受体与增生性瘢痕间的因果关系
Hong-Fang Ma,Jun Shen
Hong-Fang Ma
During the formation of hypertrophic scars (HS), there is often a notable abnormal proliferation and differentiation of cells, especially fibroblasts, but it remains ambiguous whether a causal relationship exists between fibroblast growth f...
Mana Mitsutani,Hiromi Hano,Mei Yokoyama et al.
Mana Mitsutani et al.
GATA proteins have been proposed as regulators of adipogenesis. In particular, GATA2 and GATA3 have been demonstrated to function in preadipocytes, and their behavior in response to extracellular signals allows preadipocytes to transition i...
Activation of the non-canonical Wnt5a signaling pathway following optic nerve injury induces time-dependent changes in pro- and anti-inflammatory gene expression [0.03%]
视神经损伤后非典型Wnt5a信号通路的激活诱导促炎和抗炎基因的时间依赖性变化
Alexander W Venanzi,Gabrielle A Albano,Paola E Parrales et al.
Alexander W Venanzi et al.
Optic nerve (ON) injury leads to retinal ganglion cell (RGC) degeneration and axonal atrophy. Wnt ligands are embryonic growth factors that regulate cellular differentiation and survival. We recently demonstrated that canonical and non-cano...