Effects of aging in combination with high-fat or ketogenic diet on skeletal muscle hypertrophy after functional overloading in C57BL/6J mice [0.03%]
高脂饮食或生酮饮食联合老龄对C57BL/6J小鼠功能性过负荷后骨骼肌肥大影响的比较研究
Mantas Dirmontas,Petras Minderis,Aivaras Ratkevicius
Mantas Dirmontas
We investigated how aging interacts with high-fat (HFD) and ketogenic (KD) diets to influence functional overload (FO)-induced muscle hypertrophy in C57BL/6J mice. Male mice aged 3, 16, and 24 months were fed regular chow (RD), HFD, or KD f...
BMP7 peripheral sequence evolution correlates with mammalian cloacal septation [0.03%]
BMP7周边序列进化与哺乳动物泄殖腔分隔相关性研究
Aditi Kaloni,Meghal Vaishnani,Mansi Popat et al.
Aditi Kaloni et al.
Vertebrate evolution from a single multipurpose cloaca to separate urogenital and anal openings remains a central molecular question with relevance to reproductive diversification and anorectal malformations. We investigated BMP7, a critica...
The role of the epidermal growth factor in the pathogenesis of schizophrenia. Clinical and diagnostic value [0.03%]
表皮生长因子在精神分裂症发病机制中的作用。临床和诊断价值
Daria Piskareva,Yana Zorkina,Alisa Andryushenko et al.
Daria Piskareva et al.
Research increasingly implicates neuroimmune inflammation in schizophrenia, with the epidermal growth factor (EGF) family as a potential link. This review critically evaluates EGF family members as diagnostic, risk, and treatment response m...
The role of ERK signaling pathway in pituitary adenomas: from molecular mechanisms to targeted therapy [0.03%]
ERK信号通路在垂体腺瘤中作用的研究：从分子机制到靶向治疗研究
Jingwei Ye,Yuan Wen,Jingyang Zhan et al.
Jingwei Ye et al.
ERK, a core member of the MAPK family, operates through the classical Ras/Raf/MEK/ERK signaling cascade. Abnormal activation of this pathway is closely associated with malignant tumor progression and represents a critical target in anticanc...
Role of soluble EGFR, Fas, and Fas ligand in pelvic pain severity and their association with endometriosis in infertile woman: a case-control study [0.03%]
可溶性EGFR、Fas和Fas配体在盆腔痛严重程度的作用及其与不孕症妇女子宫内膜异位症的关系：一项病例对照研究
Fadhil Ahsan,Nanda Yuli Rahmawati,Fidyah Nanda Alditia et al.
Fadhil Ahsan et al.
Endometriosis, a chronic inflammatory condition linked to pelvic pain and infertility, is characterized by immune dysfunction involving dysregulated apoptosis and cell proliferation. This case-control study included 87 infertile women under...
ErbB receptor stimulation is required for mouse Colon adenoma organoids to form crypts [0.03%]
ErbB受体刺激是小鼠结肠腺瘤类器官形成隐窝所必需的条件
Chin Wee Tan,Ruiyan Zhu,Serena R Kane et al.
Chin Wee Tan et al.
When cultured with Wnt, R-spondin, EGF, Noggin, myofibroblast conditioned medium and Matrigel, crypts from normal mouse colon mucosa form crypt-producing organoids and can be passaged every seven days. Under the same culture and passage con...
Chorioallantoic membrane assay demonstrating pro-angiogenic properties of BRAF inhibitor: a tool to treat chronic wounds [0.03%]
BRAF抑制剂促血管生成性质的卵黄囊膜实验测定：治疗慢性伤口的一种手段
Sonali Karhana,Yasmin Sultana,Nilanjan Saha et al.
Sonali Karhana et al.
The aim of the study was to evaluate the angiogenic potential and safety of Dabrafenib, a BRAF inhibitor, for wound healing applications using the chick embryo Chorioallantoic Membrane (CAM) assay. Fertilized chicken eggs were incubated, an...
Extracellular matrix biomarkers and transforming growth factor-β in hypertrophic cardiomyopathy: interaction between biomarkers [0.03%]
肥厚型心肌病的细胞外基质生物标志物及转化生长因子-β相互作用研究
Nesrine Fourti,Manel Ben Halima,Wiem Zidi et al.
Nesrine Fourti et al.
Significant dysregulation of matrix metalloproteinase (MMPs), their tissue inhibitors (TIMPs) and profibrotic cytokines have been reported in hypertrophic cardiomyopathy (HCM) and associated with adverse cardiac remodeling. We aim to invest...
Growth factors loaded chitosan scaffolds as bioactive biomimetic multifunctional platforms in periodontal tissue engineering: a review [0.03%]
负载生长因子的壳聚糖支架作为牙周组织工程中的生物活性仿生多功能平台：综述
Mohammed Alkandari,Meshari Alkandari,Gamal Abdel Nasser Atia et al.
Mohammed Alkandari et al.
Periodontitis causes severe tissue loss, making predictable regeneration a major challenge. Growth factor-loaded chitosan scaffolds offer a promising, multifunctional approach to enhance tissue regeneration. This review explores their desig...
Functional characterization of a clinically significant variant of IGF1R (M1054I) - a critical residue involved in defining the binding of small molecules in the allosteric pocket of IGF1R [0.03%]
IGF1R（M1054I）临床显著变异的功能表征——定义IGF1R的小分子结合的变构袋的关键残基
Farheen Showket,Aubaidah Akhtar,Sabra Parveen et al.
Farheen Showket et al.
IGF1R, a receptor tyrosine kinase, is crucial for cell growth, proliferation, and differentiation. Overexpression of IGF1R is linked to cancer and resistance to therapies, making it a target for drug development. Previously, we identified a...