DNA methyltransferase 1-mediated methylation of midkine regulate myocardial ischemia-reperfusion injury via the Notch2/Hes1 axis [0.03%]
DNA甲基转移酶1介导的.midkine甲基化通过Notch2/Hes1轴调节心肌缺血再灌注损伤
Wei Liu,Yuqin Wang,Jiayuan Wu et al.
Wei Liu et al.
myocardial ischemia-reperfusion injury (MI/RI) threatens people's lives. Midkine (MDK) has a protective effect against MI/RI. DNA methyltransferase 1 (DNMT1) is closely associated with MI/RI. Mouse cardiomyocytes were isolated to establish ...
Mendelian randomization analyses explore the causal relationship between fibroblast growth factor receptors and hypertrophic scar [0.03%]
孟德尔随机化分析探讨成纤维细胞生长因子受体与增生性瘢痕间的因果关系
Hong-Fang Ma,Jun Shen
Hong-Fang Ma
During the formation of hypertrophic scars (HS), there is often a notable abnormal proliferation and differentiation of cells, especially fibroblasts, but it remains ambiguous whether a causal relationship exists between fibroblast growth f...
Mana Mitsutani,Hiromi Hano,Mei Yokoyama et al.
Mana Mitsutani et al.
GATA proteins have been proposed as regulators of adipogenesis. In particular, GATA2 and GATA3 have been demonstrated to function in preadipocytes, and their behavior in response to extracellular signals allows preadipocytes to transition i...
Activation of the non-canonical Wnt5a signaling pathway following optic nerve injury induces time-dependent changes in pro- and anti-inflammatory gene expression [0.03%]
视神经损伤后非典型Wnt5a信号通路的激活诱导促炎和抗炎基因的时间依赖性变化
Alexander W Venanzi,Gabrielle A Albano,Paola E Parrales et al.
Alexander W Venanzi et al.
Optic nerve (ON) injury leads to retinal ganglion cell (RGC) degeneration and axonal atrophy. Wnt ligands are embryonic growth factors that regulate cellular differentiation and survival. We recently demonstrated that canonical and non-cano...
VEGF ameliorates acute kidney injury by suppressing ferroptosis through activation of the ERK1/2-NRF2 pathway [0.03%]
VEGF通过激活ERK1/2-NRF2信号通路抑制铁死亡从而改善急性肾损伤
Xiangtian Liu,Yuqi Song,Weikun Tian et al.
Xiangtian Liu et al.
Vascular endothelial growth factor (VEGF) plays a crucial role in maintaining renal homeostasis. However, the precise impact of VEGF on ferroptosis in acute kidney injury (AKI) remains incompletely understood. This study aims to investigate...
Insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 in central precocious puberty: a systematic review and meta-analysis [0.03%]
中枢性早熟的胰岛素样生长因子1和胰岛素样生长因子结合蛋白3的系统评价和meta分析
Yunyun Wu,Weili Zhao
Yunyun Wu
To identify distinct patterns of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein 3 (IGFBP-3) in girls with central precocious puberty (CPP), and to compare IGF-1 and IGFBP-3 levels in patients with CPP an...
Mesencephalic astrocyte-derived neurotrophic factor: a potential diagnostic marker in human sepsis-associated lung injury [0.03%]
.midbrain胶质细胞源性神经营养因子：人类脓毒症相关性肺损伤潜在的诊断标志物
Yan Zhou,Ni Yao,Jing-Wen Zheng et al.
Yan Zhou et al.
Systemic inflammatory response syndrome (SIRS) commonly considered as the first step in the sepsis cascade. To evaluate the diagnostic value and potential mechanism of serum MANF in sepsis-associated lung injury (SALI), 15 adult SALI patien...
An endothelial cell competition assay for determinants of the response to targeted anti-angiogenics [0.03%]
内皮细胞竞争测定法：靶向抗血管生成药物反应决定因素的测定
Michael M Halford,Michael Y He,Nancy Amin et al.
Michael M Halford et al.
ABSTRACT/SUMMARYAnti-angiogenics, inhibitors of pathological blood vessel growth, are an important class of targeted agent for the treatment of common cancers and ocular conditions. However, efficacy is compromised by the absence of biomark...
Various strategies to induce beta cell neogenesis: a comprehensive review for unravelling the potential future therapy for curing diabetes [0.03%]
β细胞新生的多种策略：全面回顾以揭示潜在治愈糖尿病的未来疗法
Anjali Patel,B Rajgopal,Manisha Jaiswal
Anjali Patel
Pancreatic endocrine cells are categorized in to 5 types (alpha, beta, delta, pancreatic polypeptide cells and epsilon), which expresses glucagon, insulin, somatostatin, pancreatic polypeptide, and ghrelin, respectively. Several studies inc...
Oxaloacetate stimulates phosphorylation of epidermal growth factor receptor in epithelial cells in vitro [0.03%]
草酰乙酸通过体外实验刺激上皮细胞中的表皮生长因子受体磷酸化
Ye Kuang,Yuxiang Zhao,Zeyu Miao et al.
Ye Kuang et al.
Oxaloacetate (OA) is a pivotal endogenous metabolite. Within our investigation, we ascertained that OA functions as an agonist for the epidermal growth factor receptor (EGFR), a key protagonist in the genesis of diverse tumours. We substant...