Cytoplasmic tail of coronavirus spike protein has intracellular targeting signals [0.03%]
冠状病毒刺突蛋白胞质尾含有的细胞内定位信号
Jibin Sadasivan,Manmeet Singh,Jayasri DAS Sarma
Jibin Sadasivan
Intracellular trafficking and localization studies of spike protein from SARS and OC43 showed that SARS spike protein is localized in the ER or ERGIC compartment and OC43 spike protein is predominantly localized in the lysosome. Differentia...
Inactivation of RAD52 and HDF1 DNA repair genes leads to premature chronological aging and cellular instability [0.03%]
RAD52和HDF1DNA修复基因失活导致过早的生理老化和细胞不稳定
Silvia Mercado-Saenz,Beatriz Lopez-Diaz,Francisco Sendra-Portero et al.
Silvia Mercado-Saenz et al.
The present study aims to investigate the role of radiation sensitive 52 (RAD52) and high-affinity DNA binding factor 1 (HDF1) DNA repair genes on the life span of budding yeasts during chronological aging. Wild type (wt) and rad52, hdf1, a...
Genetic diagnosis of a Chinese multiple endocrine neoplasia type 2A family through whole genome sequencing [0.03%]
中国多发性内分泌腺瘤病2型家庭的基因诊断——全基因组测序的应用
Zhen-Fang DU,Peng-Fei Li,Jian-Qiang Zhao et al.
Zhen-Fang DU et al.
Approximately 98% of patients with multiple endocrine neoplasia type 2A (MEN 2A) have an identifiable RET mutation. Prophylactic or early total thyroidectomy or pheochromocytoma/parathyroid removal in patients can be preventative or curativ...
Untranslated regions of mRNA and their role in regulation of gene expression in protozoan parasites [0.03%]
原生动物病原体中mRNA的非编码区及其对基因表达调控的作用
Shilpa J Rao,Sangeeta Chatterjee,Jayantapal K Pal
Shilpa J Rao
Protozoan parasites are one of the oldest living entities in this world that throughout their existence have shown excellent resilience to the odds of survival and have adapted beautifully to ever changing rigors of the environment. In view...
Non-ribosomal peptide synthetases: Identifying the cryptic gene clusters and decoding the natural product [0.03%]
非核糖体肽合成酶：识别隐秘的基因簇并解析天然产物
Mangal Singh,Sandeep Chaudhary,Dipti Sareen
Mangal Singh
Non-ribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs) present in bacteria and fungi are the major multi-modular enzyme complexes which synthesize secondary metabolites like the pharmacologically important antibiotics and...
Chaitanya Kumar,Sakshi Kohli,Poonamalle Parthasarathy Bapsy et al.
Chaitanya Kumar et al.
The interplay between host immunity and tumour cells has opened the possibility of targeting tumour cells by modulation of the human immune system. Cancer immunotherapy involves the treatment of a tumour by utilizing the recombinant human i...
Diverse roles of WDR5-RbBP5-ASH2L-DPY30 (WRAD) complex in the functions of the SET1 histone methyltransferase family [0.03%]
WDR5-RbBP5-ASH2L-DPY30(WRAD)复合体在SET1组蛋白甲基转移酶家族功能中的多种作用
Aamir Ali,Shweta Tyagi
Aamir Ali
WD repeat containing protein 5 (WDR5), Retinoblastoma Binding Protein 5 (RbBP5), Absent-Small-Homeotic-2- Like protein (ASH2L), and Dumpy-30 (Dpy30) have been reported to be the integral and shared components of all the SET1 family of histo...
Robin Sebastian,Sathees C Raghavan
Robin Sebastian
Endosulfan is a broad-spectrum organochlorine pesticide, speculated to be detrimental to human health in areas of active exposure. However, the molecular insights to its mechanism of action remain poorly understood. In two recent studies, o...
Female conspecifics restore rhythmic singing behaviour in arrhythmic male zebra finches [0.03%]
雌性同类能恢复斑胸草雀的雄性的无节律鸣叫行为
Neelu Anand Jha,Vinod Kumar
Neelu Anand Jha
The present study investigated whether pairing with a conspecific female would restore rhythmicity in the singing behaviour of arrhythmic male songbirds. We recorded the singing and, as the circadian response indicator, monitored the activi...
Early life stress experience may blunt hypothalamic leptin signalling [0.03%]
早期生活压力经历可能会使下丘脑瘦素信号传导钝化
J H Lee,S B Yoo,J Y Kim et al.
J H Lee et al.
The aim of this study was to investigate whether neonatal maternal separation (MS) - chronic stress experience in early life - affects the anorectic efficacy of leptin in the offspring at adolescence. Sprague-Dawley pups were separated from...