Hypercholesterolemia-induced impairment in sorafenib functionality is overcome by avasimibe co-treatment [0.03%]
阿伐他滨联合治疗可克服高胆固醇引起的索拉非尼功能障碍
Dipti Athavale,Himanshi Yaduvanshi,Firoz Khan Bhati et al.
Dipti Athavale et al.
Avasimibe, a cholesterol-lowering drug with proven safety in clinical trials, has also been repositioned as an anticancer agent in various preclinical investigations. A study from our group reported that hypercholesterolemia promotes hepato...
Evolutionary trade-offs in plant immunity: prioritizing antiviral priming by herbivore-induced plant volatiles over defense against herbivores [0.03%]
植物免疫中的进化权衡：通过植食昆虫诱导的植物挥发物优先进行抗病毒启动而非防御植食害虫
Pachamuthu Megaladevi,Jyothilakshmi Vadassery
Pachamuthu Megaladevi
Antipathogen defense; b-caryophyllene; vector-virus mutualism Plants respond to insect herbivory by producing and releasing distinctive blends of volatile compounds. These herbivore-induced plant volatiles (HIPVs) serve several roles, inclu...
Review
Journal of biosciences. 2026:51:25. DOI: 2026
Birds and bees do not express RAGE: comparative physiology and non-conventional model organisms hold the key to hyperglycemia tolerance [0.03%]
鸟类和蜜蜂不会表达RAGE：比较生理学和非传统模式生物对高血糖耐受性的启示
Renee M Borges
Renee M Borges
Much of the diversity of life is fueled by sugar. The Maillard reaction and subsequent formation of advanced glycated end products (AGEs) are key contributors to hyperglycemia-associated pathologies. Interestingly, birds maintain glucose le...
Dengxing Li,Bao Liao,Huimin Wei et al.
Dengxing Li et al.
This study aims to explore the characteristics and differentiation pathways of microglia and macrophages using single-cell transcriptome data from mouse stroke models. The clusters of microglia and macrophages in the middle cerebral artery ...
Dynamic attributes of the pedicel: Key drivers, structure and function in angiosperms [0.03%]
花梗的动态属性：被子植物中的关键驱动因素、结构和功能
Shveta Saroop,Monika Koul,Veenu Kaul
Shveta Saroop
Pedicels, the short specialized stems that support reproductive structures in flowering plants, play diverse roles throughout plant development, yet many of their functions remain insufficiently understood. Morphologically and anatomically,...
Review
Journal of biosciences. 2026:51:20. DOI: 2026
Cardiometabolomic signatures and gut microbiota dynamics in perinatally undernourished F1 offspring: Decoding the metabolic footprint [0.03%]
母代围产期营养不良F1后代的心血管代谢组和肠道菌群动态变化：解码代谢特征
Anu V Ranade,Pramukh Subrahmanya Hegde,Megha Bhat Agni et al.
Anu V Ranade et al.
The Developmental Origins of Health and Disease (DOHaD) hypothesis asserts that detrimental prenatal conditions, such as dietary deficiencies, may lead to enduring health consequences. Perinatal undernutrition, an important concern during f...
Michelle Modert,Tom Masselter,Thomas Speck
Michelle Modert
The processes of cellular differentiation and tissue maturation in the early phases of leaf development have been the subject of extensive investigation. During leaf opening, however, a subsequent stage of development, the dynamics of cell ...
Computational insights into cancer stem cell dynamics and the urokinase plasminogen activation pathway [0.03%]
计算分析癌干细胞动态及尿激酶纤溶激活途径的 insight
Kumari Neelam Verma,Debabrata Dasgupta
Kumari Neelam Verma
This study introduces a novel computational model that integrates cancer stem cells (CSCs) and the plasminogen activation system, filling a crucial gap in cancer research. While theoretical models have separately explored CSCs and the plasm...
Structure evaluation coupled with all-atom molecular dynamics and advanced quantum mechanical DFT revealed kaempferol as a potent binding flavonol for the epigenetic-target HDAC9 [0.03%]
结构评估结合全原子分子动力学和高级量子力学DFT揭示了 kaempferol 是表观遗传靶标HDAC9的强结合黄酮醇
Shabir Ahmad Ganai,Sundararaj Rajamanikandan,Shahid Ahmad Padder
Shabir Ahmad Ganai
Aberrant histone deacetylase-9 (HDAC9) activity has been recorded in a plethora of malignant tumors, including gastric cancer, hepatocellular carcinoma, and non-small cell lung cancer. Despite the discovery of HDAC9 as an important pharmaco...
Response of mycorrhizal fungal communities to tree species composition and soil properties in the Miombo subtropical dry forest [0.03%]
米翁波亚热带干阔叶林中菌根真菌群落对树种组成和土壤因子的响应
Likulunga Emmanuel Likulunga,Bethan Manley,Mashuta Kalebe et al.
Likulunga Emmanuel Likulunga et al.
Miombo forests are ecologically and economically important; however, knowledge about mycorrhizal assemblages harboured by these ecosystems and the driving factors is scarce. We investigated the composition and diversity of soil arbuscular a...