PPE18 protein of Mycobacterium tuberculosis downregulates LPS-induced IgG production by inhibiting nitric oxide synthesis [0.03%]
结核分枝杆菌PPE18蛋白通过抑制一氧化氮的合成下调LPS诱导的IgG产生
Brahmaji Sontyana,Asma Ahmed,Sangita Mukhopadhyay
Brahmaji Sontyana
Mycobacterial PPE18 is a virulence factor. Previous studies have demonstrated that recombinant PPE18 protein (rPPE18) downregulates inflammation-induced nitric oxide synthase (iNOS) and nitric oxide (NO) production. Given its ability to inh...
Exploring the functional roles of secondary metabolites in Brassica defense networks [0.03%]
探讨次生代谢产物在油菜防御网络中的功能作用
Neha Singh,Shubhra Barwa,Neelam Prabha Negi et al.
Neha Singh et al.
Plants produce a diverse array of secondary metabolites (SMs) that play critical roles in adaptation to environmental challenges and defense against pathogens and herbivores. Brassica species accumulate a wide range of SMs, including glucos...
Evaluation of insecticide susceptibility variation in different field populations of the cabbage aphid, Brevicoryne brassicae (Hemiptera: Aphididae), to selected organophosphate insecticides [0.03%]
几种有机磷杀虫剂对菜蚜田间种群抗药性差异的评价
Irfan Ahmad Mir,Bazila Rehman,Barkat Hussain et al.
Irfan Ahmad Mir et al.
Brevicoryne brassicae (Linnaeus), the cabbage aphid, is a destructive pest of cruciferous crops worldwide. In Kashmir, management relies heavily on organophosphate insecticides, yet regional susceptibility data are lacking. This study evalu...
Delta-9-tetrahydrocannabinol delineates D-galactose and aluminium chloride-induced cognitive dysfunction and neurodegeneration in the hippocampus of the Wistar rat model [0.03%]
大麻素分离D半乳糖和氯化铝诱导的威斯特大鼠海马区认知障碍和神经退行性疾病模型
Fatin Nadzirah Zakaria,Mohamad Taufik Hidayat Baharuldin,Che Norma Mat Taib et al.
Fatin Nadzirah Zakaria et al.
Alzheimer's disease (AD) is a neurodegenerative disorder characterised by neurodegeneration and a decline in cognition and memory. D-galactose (D-gal) and aluminium chloride (AlCl3) have been used to induce cognitive deterioration in rat mo...
Cross-sectional associations between plasma copper, zinc and prediabetes among rural Indian adolescent girls: baseline data from the DERVAN cohort (DERVAN-8) [0.03%]
印度农村少女血清铜、锌与糖耐量异常的横断面研究（DERVAN-8）基线数据
Suvarna Patil,Netaji Patil,Rohit Bhat et al.
Suvarna Patil et al.
Copper and zinc are essential minerals for proper metabolic function, and their imbalance could potentially cause prediabetic conditions. We investigated associations of copper and zinc with glycaemic parameters in 1473 adolescent girls age...
Expression of Nischarin increases with postnatal hippocampal maturation and regulates cofilin phosphorylation [0.03%]
Nischarin在产后海马成熟过程中的表达逐渐增强并调节可诱导肌动蛋白解聚蛋白(cofilin)的磷酸化状态
Aiwu Huang,Changfen Xu,Wanghuan Chen et al.
Aiwu Huang et al.
The hippocampus, critical for memory integration and synaptic plasticity, undergoes cytoskeletal reorganization during development and maturation, a process regulated by cofilin phosphorylation dynamics. Nischarin is a tumor-suppressive sca...
Hypercholesterolemia-induced impairment in sorafenib functionality is overcome by avasimibe co-treatment [0.03%]
阿伐他滨联合治疗可克服高胆固醇引起的索拉非尼功能障碍
Dipti Athavale,Himanshi Yaduvanshi,Firoz Khan Bhati et al.
Dipti Athavale et al.
Avasimibe, a cholesterol-lowering drug with proven safety in clinical trials, has also been repositioned as an anticancer agent in various preclinical investigations. A study from our group reported that hypercholesterolemia promotes hepato...
Evolutionary trade-offs in plant immunity: prioritizing antiviral priming by herbivore-induced plant volatiles over defense against herbivores [0.03%]
植物免疫中的进化权衡：通过植食昆虫诱导的植物挥发物优先进行抗病毒启动而非防御植食害虫
Pachamuthu Megaladevi,Jyothilakshmi Vadassery
Pachamuthu Megaladevi
Antipathogen defense; b-caryophyllene; vector-virus mutualism Plants respond to insect herbivory by producing and releasing distinctive blends of volatile compounds. These herbivore-induced plant volatiles (HIPVs) serve several roles, inclu...
Review
Journal of biosciences. 2026:51:25. DOI: 2026
Birds and bees do not express RAGE: comparative physiology and non-conventional model organisms hold the key to hyperglycemia tolerance [0.03%]
鸟类和蜜蜂不会表达RAGE：比较生理学和非传统模式生物对高血糖耐受性的启示
Renee M Borges
Renee M Borges
Much of the diversity of life is fueled by sugar. The Maillard reaction and subsequent formation of advanced glycated end products (AGEs) are key contributors to hyperglycemia-associated pathologies. Interestingly, birds maintain glucose le...
Dengxing Li,Bao Liao,Huimin Wei et al.
Dengxing Li et al.
This study aims to explore the characteristics and differentiation pathways of microglia and macrophages using single-cell transcriptome data from mouse stroke models. The clusters of microglia and macrophages in the middle cerebral artery ...