Inactivation of RAD52 and HDF1 DNA repair genes leads to premature chronological aging and cellular instability
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The present study aims to investigate the role of radiation sensitive 52 (RAD52) and high-affinity DNA binding factor 1 (HDF1) DNA repair genes on the life span of budding yeasts during chronological aging. Wild type (wt) and rad52, hdf1, and rad52 hdf1 mutant... ...