PPE18 protein of Mycobacterium tuberculosis downregulates LPS-induced IgG production by inhibiting nitric oxide synthesis
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Mycobacterial PPE18 is a virulence factor. Previous studies have demonstrated that recombinant PPE18 protein (rPPE18) downregulates inflammation-induced nitric oxide synthase (iNOS) and nitric oxide (NO) production. Given its ability to inhibit iNOS, we invest... ...
