Synthesis of (R)- and (S)-β-hydroxyphosphonate acyclonucleosides: structural analogues of Adefovir (PMEA) [0.03%]
(R)-和(S)-β-羟基磷取代的acyclonucleoside合成：与Adefovir(PMEA)具有类似结构的化合物
Mahesh Kasthuri,Laurent Chaloin,Christian Périgaud et al.
Mahesh Kasthuri et al.
A synthetic pathway to new acyclonucleoside phosphonates, as analogues of Adefovir, is described. The reduction of an acyclonucleoside β-ketophosphonate, readily available from the nucleobase and benzylacrylate, afforded a mixture of (R)- ...
Alexander W Schuppe,James M Cabrera,Catherine L B McGeoch et al.
Alexander W Schuppe et al.
Several Gold's reagents were synthesized from cyanuric chloride and N,N-dialkylformamides. These synthetic equivalents of N,N-dimethylformamide dimethyl acetal were used in an optimized and scalable procedure for the regioselective synthesi...
C 2-Symmetric chiral bis(oxazoline)-metal complexes in catalytic asymmetric synthesis [0.03%]
手性双噁唑烷金属配合物在催化不对称合成中的应用研究
Arun K Ghosh,Packiarajan Mathivanan,John Cappiello
Arun K Ghosh
Bis(oxazoline) derived cationic aqua complexes: highly effective catalysts for enantioselective Diels-Alder reactions [0.03%]
由双噁唑啉衍生的𬭩配合物催化Diels-Alder反应的研究进展
Arun K Ghosh,Hanna Cho,John Cappiello
Arun K Ghosh
Cationic aqua complex derived from bidentate inda-box ligand and Cu(ClO4)2·6H2O is an excellent catalyst (5-10 mol%) for enantioselective (92-99% ee) Diels-Alder reactions of cyclopentadiene and various bidentate dienophiles.
ASYMMETRIC HETERO DIELS-ALDER REACTIONS OF DANISHEFSKY'S DIENE AND GLYOXYLATE ESTERS CATALYZED BY CHIRAL BISOXAZOLINE DERIVED CATALYSTS [0.03%]
戴尼司夫基二烯与邻甲醛酯的不对称杂迪尔斯-阿尔德反应研究
Arun K Ghosh,Packiarajan Mathivanan,John Cappiello et al.
Arun K Ghosh et al.
Asymmetric hetero Diels-Alder reactions of Danishefsky's diene and glyoxylate esters catalyzed by bis(oxazoline)-metal complex afforded the corresponding aldol adduct which upon treatment with trifluoroacetic acid furnished the hetero Diels...
An enantioselective synthesis of the core unit of the non-nucleoside reverse transcriptase inhibitor taurospongin A [0.03%]
taujoanosineA核心单元的不对称合成方法研究
Arun K Ghosh,Hui Lei
Arun K Ghosh
An enantioselective formal synthesis of taurospongin A has been achieved. The key steps involve chelation-controlled reductions of β-ketosulfoxide and β-hydroxy ketone intermediates and Sharpless asymmetric epoxidation to construct the te...
Asymmetric alkylations and aldol reactions: (1 S,2 R)-2-aminocyclopentan-1-ol derived new chiral auxiliary [0.03%]
不对称烷基化和aldol反应：新的手性辅助剂(1S，2R)-2-氨基环戊醇
Arun K Ghosh,Hanna Cho,Masanobu Onishi
Arun K Ghosh
Asymmetric alkylation and aldol reaction of optically active (1S,2R)-2-aminocyclopentan-l-ol derived chiral auxiliary proceeded with excellent diastereofacial selectivities (>99%) and isolated yields.
ASYMMETRIC DIELS-ALDER REACTION : CIS-1-ARYLSULFONAMIDO-2-INDANOLS AS HIGHLY EFFECTIVE CHIRAL AUXILIARIES [0.03%]
不对称Diels-Alder反应：含有芳基磺酰氨基的顺式-2-茚醇作为高效的助剂分子
Arun K Ghosh,Packiarajan Mathivanan
Arun K Ghosh
Lewis acid promoted Diels-Alder reaction of acrylate esters of cis-1-arylsulfonamido-2-indanols and cyclopentadiene provided exclusively endo-adducts with high endo-diastereoselectivities.
In situ enzymatic screening (ISES) of P,N-ligands for Ni(0)-mediated asymmetric intramolecular allylic amination [0.03%]
用于镍催化不对称分子内烯丙基胺化的P,N-配体的原位酶法筛选(ISES)
David B Berkowitz,Weijun Shen,Gourhari Maiti
David B Berkowitz
An in situ enzymatic screening (ISES) approach to rapid catalyst evaluation recently pointed to Ni(0) as a new candidate transition metal for intramolecular allylic amination. This led to further exploration of chiral bidentate phosphine li...
α-Vinylic Amino Acids: Occurrence, Asymmetric Synthesis and Biochemical Mechanisms [0.03%]
乙烯基氨基酸：产生、不对称合成及生化机制研究进展
David B Berkowitz,Bradley D Charette,Kannan R Karukurichi et al.
David B Berkowitz et al.
This report presents an overview of the family of naturally occurring 'vinylic' amino acids, namely those that feature a C-C double bond directly attached to the α-carbon, along the side chain. Strategies that have been brought to bear on ...