An enantioselective synthesis of the core unit of the non-nucleoside reverse transcriptase inhibitor taurospongin A
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An enantioselective formal synthesis of taurospongin A has been achieved. The key steps involve chelation-controlled reductions of β-ketosulfoxide and β-hydroxy ketone intermediates and Sharpless asymmetric epoxidation to construct the tertiary alcohol stere... ...
