A randomized, placebo-controlled repeat-dose thorough QT study of inhaled loxapine in healthy volunteers [0.03%]
一项在健康志愿者中的利斯的明吸入剂重复给药彻底QT研究（随机、双盲、安慰剂对照）
James V Cassella,Daniel A Spyker,Paul P Yeung
James V Cassella
Objective: This randomized, double-blind, active- and placebo-controlled, crossover, thorough QT study assessed the effect of two inhaled loxapine doses on cardiac repolarization as measured by corrected QT (QTc) interval...
VKORC1 gene polymorphisms and adverse events in Croatian patients on warfarin therapy [0.03%]
Croat-warfarin患者中的VKORC1基因多态性与不良事件的关系
Dario Mandic,Nada Bozina,Sanja Mandic et al.
Dario Mandic et al.
Objective: The objective was to determine the impact of VKORC1 polymorphisms on warfarin anticoagulant therapy (stable warfarin maintenance dose, time required to reach therapeutic dose and time spent in therapeutic range...
Pharmacotherapeutic aspect of antibiotic therapy during acute community-acquired pneumonia in adults at the University Hospital of Cocody (Abidjan) [0.03%]
科特迪瓦科科杜大学医院成人社区获得性肺炎抗菌药物治疗的药理学特征分析
Gisèle Kouakou-Siransy,Kigninlman Horo,Etienne Effo et al.
Gisèle Kouakou-Siransy et al.
Objective: Acute community-acquired pneumonia in Côte d'Ivoire, mainly in the pneumology units, is the second most common cause of hospitalization after tuberculosis. This study aimed to evaluate the compliance of antibi...
Pharmacokinetic and pharmacodynamic study of dexmedetomidine in elderly patients during spinal anesthesia [0.03%]
右美托咪定在老年腰麻患者中的药代动力学和药效学研究
Yun Kuang,Ran-Ran Zhang,Qi Pei et al.
Yun Kuang et al.
Objective: The application of dexmedetomidine in patient sedation is generally accepted, though its clinical application is limited because of the lack of information detailing the specific properties among diverse popula...
Dealing with the high cost of biological therapies: developing and implementing a biological therapy prioritization protocol for ankylosing spondylitis patients in a tertiary hospital [0.03%]
高生物制剂治疗成本的对策：三级医院附条件启动生物制剂治疗以协助管理强直性脊柱炎患者
Joaquín Borrás-Blasco,Elvira Casterá,Xavier Cortes et al.
Joaquín Borrás-Blasco et al.
Objective: In January 2011, a biological therapies commission was created in our hospital to fully address the management of biological drugs. A biological therapy prioritization protocol was developed for ankylosing spon...
Patient response to insurer-led intervention for medication adherence - a pilot study based on claims data in Korea [0.03%]
基于韩国保险索赔数据的患者对保险公司主导的药物依从性干预的反应-一项试点研究
Hyun Soon Sohn,Sunmee Jang,Ju-Yeun Lee et al.
Hyun Soon Sohn et al.
Objective: This study was designed to investigate patient responses to a medication counseling intervention program piloted by the National Health Insurance Service (NHIS), the national health insurer in Korea, to improve...
Transformation of alkylating regimen of thiotepa into tepa determines the disease progression through GSTP1 gene polymorphism for metastatic breast cancer patients receiving thiotepa containing salvage chemotherapy [0.03%]
硫曲磷去烷基化生成曲磷通过GSTP1基因多态性决定转移乳腺癌患者接受含硫曲磷抢救化疗的疾病进展方向
Xinna Zhou,Xiaoli Wang,Qingkun Song et al.
Xinna Zhou et al.
Background: The shifts to second-line chemotherapy for metastatic breast cancer (MBC) were widely required based on pharmaceutical molecular profiles to reach out precision medicine. The emerging precise treatment of canc...
Pharmacokinetic comparisons of two acetyl-L-carnitine formulations in healthy Korean volunteers [0.03%]
两种乙酰左旋肉碱健康韩国受试者药代动力学比较研究
Sang-Min Baek,Renhua Zheng,Eun-Jung Seo et al.
Sang-Min Baek et al.
Background: Acetyl-L-carnitine (ALC) has demonstrated neuroprotective effects in several experiments and is widely prescribed to reduce cognitive impairment in Alzheimer's disease patients or manage neuropathic symptoms i...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2015 Nov;53(11):980-6. DOI:10.5414/CP202381 2015
Novel 4-anilino-α-carboline derivatives induce cell death in nonadhesive breast cancer cells through inhibition of Brk activity [0.03%]
新型4-苯氨基-α-卡啉衍生物通过抑制Brk活性使非粘附性乳腺癌细胞死亡
Markus Oelze,Kazem Ahmed Mahmoud,Wolfgang Sippl et al.
Markus Oelze et al.
Effect of liraglutide vs. NPH in combination with metformin on blood glucose fluctuations assessed using continuous glucose monitoring in patients with newly diagnosed type 2 diabetes [0.03%]
利拉鲁肽与NPH胰岛素联合二甲双胍治疗新诊断的2型糖尿病患者对血糖波动的影响：连续葡萄糖监测评估
Zejun Ma,Rui Chen,Yan Liu et al.
Zejun Ma et al.
Background: To evaluate the effect of liraglutide and NPH on blood glucose fluctuations in patients with newly diagnosed type 2 diabetes mellitus (T2DM). ...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2015 Nov;53(11):933-9. DOI:10.5414/CP202415 2015