Variability in belumosudil exposure due to coadministration of voriconazole and isavuconazole in a patient with chronic graft-versus-host disease: Case report [0.03%]
博利莫杜林的暴露量因伏立康唑和艾沙康唑联用而在慢性移植物抗宿主病患者中发生变化：病例报告
Mari Shimoda,Yoshito Gando,Saori Aizawa et al.
Mari Shimoda et al.
Objective: To characterize intra-patient variability in belumosudil exposure during coadministration of two azole antifungals that differ in cytochrome P450 3A4 (CYP3A4) inhibition strength - voriconazole (strong) vs. isa...
Safety profile of sintilimab and establishment of a risk prediction model based on medical records of 337 cases [0.03%]
斯鲁利单抗的安全性特征及其风险预测模型的建立——基于337例患者病历资料的研究
Chengting Rong,Hong Zhang,Ling Hu et al.
Chengting Rong et al.
Objective: To retrospectively analyze the clinical safety and adverse drug reactions (ADRs) of sintilimab, to evaluate risk factors for ADR occurrence, and to develop a predictive model to support individualized treatment...
Predictors of early discontinuation and therapeutic response to anamorelin in patients with cancer cachexia: A retrospective study [0.03%]
癌症恶病质患者阿纳莫林治疗早期停药及疗效的影响因素：一项回顾性研究
Katsuyuki Takahashi,Minami Abe,Hirotake Yamase et al.
Katsuyuki Takahashi et al.
Objective: Cancer cachexia is associated with poor tolerance to anticancer therapies and reduced survival rates. Anamorelin, a ghrelin receptor agonist, has been introduced for the management of cachexia; however, early d...
Acquired apparent mineralocorticoid excess induced by compound glycyrrhizin tablets: A case report and literature review [0.03%]
甘草片所致获得性假性盐皮质激素过多症一例及文献复习
Yu Li,Juan Du,Guojie Ma
Yu Li
Compound glycyrrhizin tablets, derived from licorice root, are widely used for their anti-inflammatory and hepatoprotective properties. However, their active metabolite, glycyrrhetinic acid, can induce acquired apparent mineralocorticoid ex...
Drug-induced dysphagia: Analysis of age and time of onset profiles using a Japanese pharmacovigilance database [0.03%]
基于日本药品不良事件数据库的药物性吞咽困难信号检测：年龄和起病时间特征分析
Eiji Kose,Mizuki Kawashima,Toshimi Kimura
Eiji Kose
Objectives: To investigate differences in drug-induced dysphagia profiles among causative drugs, with a focus on reporting risk, patient age, and time to onset. ...
Methotrexate and folic acid supplementation in rheumatoid arthritis: A Japanese claims database and 538,985 patients from April 2015 to November 2020 [0.03%]
日本claims数据库在2015年4月至2020年11月期间纳入的538,985名类风湿关节炎患者使用甲氨蝶呤和叶酸补充剂的情况
Kasumi Takabatake,Mayuko Takeda,Mutsumi Nakamura et al.
Kasumi Takabatake et al.
Objectives: To assess the use of laboratory monitoring, folic acid supplementation, and folinate calcium therapy in patients with rheumatoid arthritis (RA) receiving first-line methotrexate (MTX) according to the 2019 Jap...
Cardiac arrest in an adolescent following an overdose of antidepressants comprising sertraline, quetiapine fumarate, and lamotrigine: Case report [0.03%]
一例合并使用盐酸舍曲林、富马酸喹硫平和拉莫三嗪过量后的青少年心脏骤停病例报告
Li Zheng,Liaoyun Zhang,Fei Wang et al.
Li Zheng et al.
Antidepressant overdose is a prevalent method of self-harm in patients with depression including bipolar disorder. According to the published literature, typical adverse effects are seizures, prolonged QT intervals, and arrhythmias, with ca...
Recombinant human growth hormone in pediatric patients using the FAERS database: Safety profile and update for the period 2004 - 2024 [0.03%]
2004-2024年利用FAERS数据库分析重组人生长激素儿科患者的安全性特点及更新
Lidan Tu,Huafeng Jiang,Jianming Liu et al.
Lidan Tu et al.
Objective: To investigate safety signals associated with recombinant human growth hormone (rhGH) using the FDA Adverse Event Reporting System (FAERS) and make recommendations for its application. ...
Barrington G Woodcock-Kloberdanz
Barrington G Woodcock-Kloberdanz
Novel intravenous human IVIG in patients with secondary immunodeficiency: Interim analysis of a multicenter, prospective, non-interventional study [0.03%]
人源IVIG产品治疗二级免疫缺陷患者的疗效及安全性研究——多中心、前瞻性非干预性研究的中期分析结果
Artur Bauhofer,Silke Aigner,Stephan Borte
Artur Bauhofer
Objective: To evaluate the effectiveness, safety, and tolerability of Yimmug, a novel, highly purified, 10% human plasma-based intravenous immunoglobulin (IVIG) preparation, in patients with secondary immunodeficiency (SI...