Population pharmacokinetics study of dexmedetomidine in Chinese adult patients during spinal anesthesia [0.03%]
右美托咪啶在腰麻成人患者中药代动力学研究
Yun Kuang,Yu-xia Xiang,Cheng-Xian Guo et al.
Yun Kuang et al.
Objectives: The objectives of this study were to construct a population pharmacokinetics model for dexmedetomidine used in Chinese adult patients with spinal anesthesia and to identify the key factors affecting the pharma...
Effects of UGT1A1*6, UGT1A1*28, and ABCB1-3435C>T polymorphisms on irinotecan induced toxicity in Chinese cancer patients [0.03%]
UGT1A1*6，UGT1A1*28和ABCB1-3435C>T多态性对中国癌症患者伊立替康诱导的毒性的影响
Liang Yan,Xiao-Fei Wang,Lu-Man Wei et al.
Liang Yan et al.
Object: The aim of this study was to investigate whether UGT1A1*6/*28 or ABCB1-3435C>T polymorphisms affect irinotecan-induced severe diarrhea and neutropenia in Chinese cancer patients. ...
Intrathecal dexmedetomidine as adjuvant to ropivacaine in hysteroscopic surgery: a prospective, randomized control study [0.03%]
右美托咪啶作为利多卡因腰麻辅助用药在宫腔镜手术中的应用：一项前瞻、随机对照研究
Xiaofei Qi,Yuantao Li,Niels Rahe-Meyer et al.
Xiaofei Qi et al.
Background: To compare the effects and side effects of intrathecal ropivacaine supplemented with dexmedetomidine and fentanyl in hysteroscopic surgery under spinal anesthesia. ...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2016 Mar;54(3):185-92. DOI:10.5414/CP202427 2016
Safety, PK, and PD of recombinant anti-interleukin-21 monoclonal antibody in a first-in-human trial [0.03%]
重组抗白细胞介素-21单克隆抗体在首次人体试验中的安全性、PK和PD研究
Stanislav Ignatenko,Birte K Skrumsager,Ulrik Mouritzen
Stanislav Ignatenko
Objective: This first-in-human, randomized, double-blind, placebo-controlled trial assessed the safety of NNC0114-0005, a human recombinant anti interleukin (IL)-21 monoclonal antibody, for the treatment of rheumatoid art...
Study on rectal administration of azithromycin by suppository for pediatric use [0.03%]
阿奇霉素栓剂儿童肛用临床研究
Miyuki Maeda,Yukitaka Nakano,Takahiko Aoyama et al.
Miyuki Maeda et al.
Objective: Azithromycin (AZM) is widely used as a first-line treatment option for children with mycoplasma pneumonia. Although pharmacists perform medication counseling in the pediatric ward, children often experience vom...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2016 Apr;54(4):263-8. DOI:10.5414/CP202423 2016
No sex difference in overall P-glycoprotein activity as assessed by talinolol disposition in humans [0.03%]
以人类talinolol处置为评估方法，P-糖蛋白活性的整体上不存在性别差异
Bo Long,Yuan-Qi Su,Ying Xia et al.
Bo Long et al.
Purpose: The aim of this study was to investigate the sex-dependent difference in P-glycoprotein activity as measured by the probe drug talinolol. Methods...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2016 Mar;54(3):157-62. DOI:10.5414/CP202477 2016
The MATE1 rs2289669 polymorphism affects the renal clearance of metformin following ranitidine treatment [0.03%]
MATE1 rs2289669多态性影响ranitidine处理后二甲双胍的肾清除率
Sung Kweon Cho,Jae-Yong Chung
Sung Kweon Cho
Purpose: Human multidrug and toxin extrusion member 1 (MATE1, SLC47A1) and Organic Cation Transporter 2 (OCT2, SLC22A2) play important roles in the renal elimination of various pharmacologic agents, including the anti-dia...
Association of immune response parameters with virological response in hepatitis C virus patients treated with pegylated consensus interferon [0.03%]
长效聚乙二醇化共识干扰素治疗丙型肝炎病毒感染者疗效与免疫反应相关性研究
Yanhua Ding,Hong Zhang,Hong Chen et al.
Yanhua Ding et al.
Background: A new, potent, long lasting recombinant interferon variant (pegylated consensus interferon, PEGCIFN) was expressed by Escherichia coli. The aim of this study was to test safety and antiviral activity of the ne...
Nobuko Matsuo,Satoko Hori,Mayu Suehira et al.
Nobuko Matsuo et al.
Objective: We previously reported the first case of piloerection in a patient receiving milnacipran hydrochloride (MLP). Here, we now present a second case of MLP-induced piloerection. We discuss this effect in terms of ...
Inappropriate prescribing in polypharmacy elderly outpatients taking multiple medications. Are the STOPP criteria useful? [0.03%]
多重用药老年人的不合理处方问题。STOPP标准有用吗？
María Luisa Nicieza-Garcia,María Esther Salgueiro-Vázquez,Francisco José Jimeno-Demuth et al.
María Luisa Nicieza-Garcia et al.
Objective: To assess potentially inappropriate medications (PIMs) in elderly outpatients taking multiple medications. Methods: Invoicin...