QT-prolonging effects of monoclonal antibody drugs in humans: a systematic review of two literature and a public adverse event database [0.03%]
人用单克隆抗体药物的QT延长作用：两方面文献和公共不良事件数据库系统的回顾
Torquil Jackson,Jelena Kondic,Joerg Seebeck
Torquil Jackson
Drug-induced prolongation of the electrocardiogram QT interval, a risk factor for ventricular arrhythmia and death, has been observed for some small drugs with masses < 1 kDa. Over the last two decades, patient exposure to large molecule mo...
The genetic polymorphisms of POR*28 and CYP3A5*3 significantly influence the pharmacokinetics of tacrolimus in Chinese renal transplant recipients [0.03%]
POR*28和CYP3A5*3基因多态性对中国肾移植受者的他克莫司药代动力学具有显著影响
Jing-Jing Zhang,Shuai-Bing Liu,Ling Xue et al.
Jing-Jing Zhang et al.
Purposes: The aims of this study were to assess the influence of the polymorphism of cytochrome P450 oxidoreductase (POR) as well as other relevant genes (CYP3A4, CYP3A5, ABCB1) on individual variability of tacrolimus pha...
Bioequivalence of different dose-strength tablets of selexipag, a selective prostacyclin receptor agonist, in a multiple-dose up-titration study [0.03%]
一项多剂量滴定研究：塞利舒帕格不同规格片剂的生物等效性（一种选择性的前列腺素I受体激动剂）
Daniela Baldoni,Shirin Bruderer,Naguib Muhsen et al.
Daniela Baldoni et al.
Objective: Selexipag is a novel, oral, selective prostacyclin (PGI2) receptor agonist in clinical development for the treatment of pulmonary arterial hypertension. Film-coated tablets with strength between 200 and 1,600 ...
Evaluation of the pharmacokinetics and safety of single and multiple ceftaroline fosamil infusions in healthy Chinese and Western subjects [0.03%]
塞来昔单抗浓氨溶液在中国和西方受试者中的药代动力学及安全性评估研究
Li Yang,Maria Sunzel,Peng Xu et al.
Li Yang et al.
Objectives: Two phase I studies in healthy Chinese (NCT01458743) and Western (NCT01612507) subjects evaluated the pharmacokinetics (PK) and safety of single and multiple ceftaroline fosamil 600 mg infusions administered e...
Pharmacokinetics and safety of 3,4-diaminopyridine base in healthy Japanese volunteers [0.03%]
溴己新在健康日本受试者中的药代动力学和安全性研究
Natsuko Ishida,Erina Kobayashi,Yuya Kondo et al.
Natsuko Ishida et al.
Objective: 3,4-diaminopyridine (3,4-DAP) is commonly used for treating neuromuscular diseases, such as the Lambert-Eaton myasthenic syndrome, but the pharmacokinetics of 3,4-DAP base have not been investigated. We therefo...
Physicians' and pharmacists' acceptance of online, real-time "drug combinations to avoid" messages [0.03%]
医师和药师对在线实时“用药禁忌”消息的接受度研究
Dong-Sook Kim,Ha-Lim Jeon,Sukhyang Lee et al.
Dong-Sook Kim et al.
Drug-induced prolongation of the electrocardiogram QT interval, a risk factor for ventricular arrhythmia and death, has been observed for some small drugs with masses < 1 kDa. Over the last two decades, patient exposure to large molecule mo...
Impact of pharmacist interventions on rational prophylactic antibiotic use and cost saving in elective cesarean section [0.03%]
药师干预对择期剖宫产患者合理预防使用抗生素及节约费用的影响研究
Jingwen Wang,Mohan Dong,Yang Lu et al.
Jingwen Wang et al.
Objectives: To assess the impact of pharmacist interventions on rational use of prophylactic antibiotics and cost saving in elective cesarean section and the economic outcomes of implementing pharmacist interventions. ...
Evidence supporting the need for considering the effects of smoking on drug disposition and effectiveness in medication practices: a systematic narrative review [0.03%]
关于在用药实践中考虑吸烟对药物处置和疗效影响的证据：系统叙述性综述
Hyun Soon Sohn,Hyunah Kim,Im-Sook Song et al.
Hyun Soon Sohn et al.
This study was conducted to provide a narrative overview of interactions between smoking and drug effectiveness/ pharmacokinetics. Database searches were performed to identify review articles published prior to March 10, 2013. Eligible arti...
Effect of CYP3A4*1G, CYP3A5*3, POR*28, and ABCB1 C3435T on the pharmacokinetics of nifedipine in healthy Chinese volunteers [0.03%]
在中国健康志愿者中CYP3A4*1G、CYP3A5*3、POR*28和ABCB1 C3435T基因多态性对硝苯地平药动学的影响
Xiao-Fei Wang,Liang Yan,Hui-Min Cao et al.
Xiao-Fei Wang et al.
Objective: Nifedipine is a calcium channel blocker that is widely used in the treatment of cardiovascular disease. However, significant individual variances in the disposition of nifedipine have been reported, and genetic...
Population pharmacokinetics and safety of eptifibatide in healthy Chinese volunteers and simulations on the dose regimens approved for a Western population [0.03%]
依替巴肽在中国健康志愿者中的群体药代动力学和安全性研究及西方人群剂量 regimen 的模拟研究
Xi-Pei Wang,Zhi-Ling Zhou,Min Yang et al.
Xi-Pei Wang et al.
Objective: This study was designed to evaluate the pharmacokinetics (PK) and safety of eptifibatide in healthy Chinese volunteers and provide information for the further study in the Chinese population. ...