Safety assessment of diammonium phosphate and urea used in the manufacture of cigarettes [0.03%]
用作制备香烟原料的磷酸二铵和尿素的安全性评估
Mari S Stavanja,Geoffrey M Curtin,Paul H Ayres et al.
Mari S Stavanja et al.
A tiered testing strategy has been employed to evaluate the potential for new ingredients, tobacco processes, and technological developments to alter the mainstream smoke or biological activity that results from burning cigarette tobacco. T...
The toxic effect of pyrrolizidine alkaloid clivorine on the human embryonic kidney 293 cells and its primary mechanism [0.03%]
生物碱clivorine对人的胚肾细胞毒性作用及其主要机制研究
Li-Li Ji,Ying Chen,Zheng-Tao Wang
Li-Li Ji
Clivorine is an otonecine-type pyrrolizidine alkaloid (PA) isolated from the Chinese medicinal plant Ligularia hodgsonii Hook., and our previous reports have shown its toxicity on human normal liver L-02 cells. It is generally believed that...
Induction of COX-2 expression by acrolein in the rat model of hemorrhagic cystitis [0.03%]
丙烯醛诱发出血性膀胱炎大鼠模型COX-2表达诱导作用研究
Francisco Yuri Bulcão Macedo,Fátima Baltazar,Lívia Cajaseiras Mourão et al.
Francisco Yuri Bulcão Macedo et al.
Aim: Acrolein (ACR) is a urinary metabolite of cyclophosphamide (CPS) and ifosfamide (IFS), which has been demonstrated to be the causative agent of hemorrhagic cystitis (HC), induced by these compounds. In this study, we...
Unsymmetrical DMH - an isomer of 1,2 DMH - is it potent to induce gastrointestinal carcinoma in rats? [0.03%]
不对称DMH（1,2-二甲基 hydrazine的异构体）是否可以诱发大鼠胃肠道肿瘤？
Pamela Christudoss,R Selvakumar,Anna B Pulimood et al.
Pamela Christudoss et al.
Very few animal studies have used 1,1-dimethyl hydrazine (unsymmetrical dimethyl hydrazine - UDMH) as a carcinogen. This study was designed to investigate the carcinogenicity of UDMH in the gastrointestinal tract in a rat model. We wanted t...
Ketoconazole-induced testicular damage in rats reduced by Gentiana extract [0.03%]
雷公藤提取物减轻酮康唑致大鼠睾丸损伤
Amr Amin
Amr Amin
Ketoconazole (KET) is an antifungal drug with a broad spectrum of activity that also induces reproductive toxicity in humans and animals. The protective effect of Gentiana (GEN) extract (Gentiana lutea) against KET-induced testicular damage...
The effects of intra-rectal and intra-peritoneal application of Origanum onites L. essential oil on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in the rat [0.03%]
百里香酚油对诱发的大鼠结肠炎的影响
Emine Dundar,Esra Gurlek Olgun,Serap Isiksoy et al.
Emine Dundar et al.
The aim of the present study is to investigate the treatment efficiency of intra-rectal (IR) and intra-peritoneal (IP) application of Origanum onites essential oil (OOEO), which is a well-known antioxidant, in the colitis model induced by 2...
An atypical case of histiocytic sarcoma in a Wistar rat (Rattus norvegicus) [0.03%]
一只大鼠(Wistar)的噬史氏细胞肉瘤的非典型病例
Anne-Laure Bauchet,Marie-Claude Fouque,Sara Belluco et al.
Anne-Laure Bauchet et al.
Histiocytic sarcoma is the most frequent hematopoietic tumor in rats. We report here a histiocytic sarcoma infiltrating the liver, the spleen and the pancreas from a Wistar rat. In the liver, the tumor was associated with oval cell and bile...
N-nitrosodiethylamine-induced toxicity in relation to oxidative stress and development of atherosclerosis in hypercholesterolemic diet-fed rabbits [0.03%]
与氧化应激及动脉粥样硬化发展相关的N-二乙基亚硝胺毒性：高胆固醇饮食喂养的兔模型研究
Gaurav Mittal,Apminder Pal Singh Brar,Giridhar Soni
Gaurav Mittal
N-nitrosodiethylamine (NDEA) is an important carcinogenic nitrosamine frequently present in human environment, besides being a part of the human food chain by virtue of its reported presence in various foodstuffs and beverages. This study w...
Differential modulation of PPARalpha and gamma target gene expression in the liver and kidney of rats treated with aspirin [0.03%]
阿司匹林处理的大鼠肝脏和肾脏中PPARα与γ靶基因表达的差异调控研究
Marco Fidaleo,Emanuele Berardi,Claudia Sartori
Marco Fidaleo
Aspirin modified peroxisomal enzymatic activities both in the liver and renal cortex of rats, producing typical effects of peroxisomal proliferators (PPs). Although similar increments in beta-oxidation system and catalase activities were ob...
Shipra Sharma,Rajendra P Goyal,Geetanjali Chakravarty et al.
Shipra Sharma et al.
Colour in food is an integral part of our culture and is also indispensable to the modern day consumer. During the past several decades, the technology of food processing has changed dramatically and the growth in the use of synthetic food ...