Neuroendocrine disorders in adult rats treated prenatally with hydrocortisone acetate [0.03%]
孕期用氢化可的松乙酸酯处理的大鼠成年后发生神经内分泌紊乱
Alexander Reznikov,Nadezhda Nosenko,Larisa Tarasenko et al.
Alexander Reznikov et al.
We investigated the effects of hydrocortisone acetate administered to pregnant rats over the last gestational week on some neuroendocrine characteristics in adult female and male offspring. Prenatal glucocorticoid eliminated sex dimorphism ...
Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats [0.03%]
尼古丁处理及戒断对大鼠随机模式皮肤皮瓣的影响
José Humberto O Campos,Heitor Carvalho Gomes,Washington L C dos-Santos et al.
José Humberto O Campos et al.
Background: Tobacco use is associated with a high incidence of skin necrosis after surgery. The ideal timing for the cessation of tobacco use before plastic surgery has not, however, been precisely determined. The aim of ...
Impact of boostering for the strength of asthma parameters and dendritic cell numbers in a C57BL/6 model of allergic airway inflammation [0.03%]
Christina Hartwig,Hanne Constabel,Detlef Neumann et al.
Christina Hartwig et al.
Background: Murine models assist in elucidating the pathogenesis of allergic asthma and evaluation of new therapeutic strategies. We aimed to assess the requirement of boostering needed in the BL/6 murine asthma model and...
Prevention of cisplatin-induced nephrotoxicity by glucosides of ascorbic acid and alpha-tocopherol [0.03%]
Dani Mathew Maliakel,Tsutomu V Kagiya,Cherupally Krishnan Krishnan Nair
Dani Mathew Maliakel
Background: Cisplatin is one of the most widely used cytotoxic therapeutic agents for the treatment of cancer. This drug, at effective higher doses, causes many physiological adverse effects such as nephrotoxicity and gen...
Establishment of a bioassay model for lung cancer chemoprevention initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice [0.03%]
Masanao Yokohira,Hijiri Takeuchi,Kousuke Saoo et al.
Masanao Yokohira et al.
Aims: In order to prevent lung cancer development in people at high risk, identification of chemopreventive agents may be important. The present study was conducted to establish a bioassay model for this purpose. In parti...
Inhibition on LS-174T cell growth and activity of telomerase in vitro and in vivo by arsenic trioxide [0.03%]
三氧化二砷体内外抑制结肠癌LS-174T细胞增殖和端粒酶活性
Xishan Wang,Guiyu Wang,Deli Dong et al.
Xishan Wang et al.
Arsenic trioxide (As2O3) shows a significant therapeutic effect upon acute promyelocytic leukemia (APL) and can induce the apoptosis of NB4 cells, which attracts scholars' great attention. Especially, the therapeutic effect on solid carcino...
Detection of reticulated platelets in whole blood of rats using flow cytometry [0.03%]
采用流式细胞仪检测大鼠全血网织血小板
Alexander Pankraz,David Ledieu,Dominique Pralet et al.
Alexander Pankraz et al.
As opposed to erythropoiesis, which is regularly assessed in the peripheral blood of animals by reticulocyte count, thrombopoiesis is rarely assessed in assays that detect immature platelets in the peripheral blood. An assessment of recent ...
Study on the relationship between cadmium chloride-induced adrenocortical cell of guinea pig apoptosis and stress-activated protein kinase activity [0.03%]
氯化镉诱导 Guinea Pig 肾上腺皮质细胞凋亡及其与应激活化蛋白激酶活性关系的研究
Zhao Min,Yang Xingfen,Wei Qing et al.
Zhao Min et al.
Heavy metals are important environmental pollutants that affect many cellular functions. The signaling pathways that lead to apoptosis of adrenocortical cells following exposure to cadmium chloride (CdCl2) have not yet been fully clarified....
Protective effects of GH and IGF-I against iron-induced lipid peroxidation in vivo [0.03%]
GH和IGF-I对抗铁诱导的脂质过氧化的保护作用
Agnieszka Kokoszko,Jan Dabrowski,Andrzej Lewiński et al.
Agnieszka Kokoszko et al.
Iron overload may enhance oxidative damage. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are involved in oxidative processes, lipid peroxidation (LPO) included. The aim of the study was to evaluate the in vivo effects of GH,...