Divergent Functionalization of Alkynes Enabled by Organic Photoredox Catalysis [0.03%]
有机光氧化还原催化烯炔的发散衍生化反应
Zhengbo Zhu,Siran Qian,David A Nicewicz
Zhengbo Zhu
Direct functionalization of alkynes under oxidative conditions is challenging, as alkynes are usually recalcitrant towards typical oxidants. Herein, we communicate a strategy for the divergent functionalization of alkynes with photoexcited ...
Malaika D Argade,Andrew P Riley
Malaika D Argade
The Aristotelia alkaloids are a family of monoterpene indole alkaloids possessing a characteristic azabicyclononane scaffold, which has been assembled by several synthetic methods. Herein we review those approaches that have adopted a biomi...
Halonium Catalysis: An Underutilized and Underexplored Catalytic Concept in Olefin Functionalizations [0.03%]
卤鎓催化：烯烃官能化中未充分利用和探索的催化概念
Nathan R Gembreska,Alexander K Vogel,Elizabeth C Ziegelmeyer et al.
Nathan R Gembreska et al.
Iodonium catalysis is described here to accomplish an intermolecular olefin oxyamination reaction. Urea is used as the O- and N-source to add across both activated and unactivated alkenes in a regioselective manner. Mechanistic studies conf...
Radical Cyclopropanol Ring Opening Initiated Tandem Cyclizations for Efficient Synthesis of Phenanthridines and Oxindoles [0.03%]
环丙醇环打开引发的串联环化反应高效合成菲啶和噁吲哚类化合物
Dexter C Davis,Christopher W Haskins,Mingji Dai
Dexter C Davis
β-Keto radicals can be readily generated from single-electron oxidation and ring opening of cyclopropanols. Herein, we report new ways of trapping β-keto radicals derived from Mn(III)-mediated oxidative cyclopropanol ring opening with bia...
Connor J O&#x;Brien,David A Nicewicz
Connor J O&#x;Brien
The use of carbon dioxide as a C1 chemical feedstock remains an active field of research. Here we showcase the use of milled dry ice as a method to promote the availability of CO2 in a reaction solution, permitting practical synthesis of ar...
Synthesis of Bifacial Peptide Nucleic Acids with Diketopiperazine Backbones [0.03%]
具有二酮哌嗪骨架的双面肽核酸的合成
Shekaraiah Devari,Debmalya Bhunia,Dennis Bong
Shekaraiah Devari
We report a synthesis of bifacial peptide nucleic acids (bPNAs) with novel diketopiperazine (DKP) backbones that display unnatural melamine (M) bases, as well as native bases. To examine the structure-function scope of DKP bPNAs, we synthes...
Access to 3D Alicyclic Amine-Containing Fragments through Transannular C-H Arylation [0.03%]
通过环上C-H芳基化获得含三唑并[1,5-a]氮杂卓片段的三维空间异构体体系
Melissa Lee,Ashley Adams,Philip B Cox et al.
Melissa Lee et al.
In this Letter, we adapt a recently reported Pd-catalyzed transannular C(sp3)-H arylation of alicyclic amines for applications in fragment-based drug discovery (FBDD). We apply this method to the synthesis of a series of 6-arylated 3-azabic...
Christian Fischer,Nynke A Vepřek,Zisis Peitsinis et al.
Christian Fischer et al.
The COVID-19 pandemic prompted many scientists to investigate remedies against SARS-CoV-2 and related viruses that are likely to appear in the future. As the main protease of the virus, MPro, is highly conserved among coronaviruses, it has ...
Synthesis of Two Stereoisomers of Potentially Bioactive 13,19,20-Trihydroxy Derivative of Docosahexaenoic Acid [0.03%]
二种潜在具有生物活性的十三碳、十九碳、二十碳三醇-docosahexanoic酸立体异构体的合成
Narihito Ogawa,Shinsaku Sone,Song Hong et al.
Narihito Ogawa et al.
The C16-C22 fragment with the acetylene terminus was constructed through the asymmetric dihydroxylation of the corresponding olefin, while the 15-iodo-olefin corresponding to the C11-C15 part was prepared via the asymmetric transfer hydroge...
Thieme Chemistry Journals Awardees - Where Are They Now? Improved Fmoc Deprotection Methods for the Synthesis of Thioamide-Containing Peptides and Proteins [0.03%]
Thieme化学期刊获奖者现状？用于合成含硫肽和蛋白质的Fmoc脱保护方法的改进
D Miklos Szantai-Kis,Christopher R Walters,Taylor M Barrett et al.
D Miklos Szantai-Kis et al.
Site-selective incorporation of thioamides into peptides and proteins provides a useful tool for a wide range of applications. Current incorporation methods suffer from low yields as well as epimerization. Here, we describe how the use of 1...