Access to 3D Alicyclic Amine-Containing Fragments through Transannular C-H Arylation
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In this Letter, we adapt a recently reported Pd-catalyzed transannular C(sp3)-H arylation of alicyclic amines for applications in fragment-based drug discovery (FBDD). We apply this method to the synthesis of a series of 6-arylated 3-azabicyclo[3.1.0]hexanes t... ...
