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Development of a Triethylborane Mediated Giese Cyclization/Aldol Reaction Cascade for the Total Synthesis of Ganoapplanin

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We present our synthetic endeavors towards the Ganoderma meroterpenoid ganoapplanin. This natural product was isolated from a Ganoderma fungus in 2016 and was found to be an inhibitor for T-type voltage-gated calcium channels. Our synthetic approach is based o... ...