Yiran Guo,Yao Yu,Gang Greg Wang
Yiran Guo
Dynamic regulation of the chromatin state by Polycomb Repressive Complex 2 (PRC2) provides an important mean for epigenetic gene control that can profoundly influence normal development and cell lineage specification. PRC2 and PRC2-induced ...
Hong Wen,Xiaobing Shi
Hong Wen
Histone proteins in eukaryotic cells are subjected to a wide variety of post-translational modifications, which are known to play an important role in the partitioning of the genome into distinctive compartments and domains. One of the majo...
The SWI/SNF Complex: A Frequently Mutated Chromatin Remodeling Complex in Cancer [0.03%]
SWI/SNF复合体：癌症中经常发生突变的染色质重塑复合体
Vinh The Nguyen,Mathewos Tessema,Bernard Ellis Weissman
Vinh The Nguyen
The switch/sucrose non-fermenting (SWI/SNF) chromatin remodeling complex is a global regulator of gene expression known to maintain nucleosome-depleted regions at active enhancers and promoters. The mammalian SWI/SNF protein subunits are en...
Yashu Li,Wen Tian,Haojian Zhang
Yashu Li
Chemical modifications on macromolecules such as DNA, RNA and proteins play important roles in almost all biological processes. The revival of RNA modification research began with the discovery of RNA modification machineries, and with the ...
Wei Liang Gan,Larry Ng,Bryan Y L Ng et al.
Wei Liang Gan et al.
RNA epigenetics, or epitranscriptome, is a growing group of RNA modifications historically classified into two categories: RNA editing and RNA modification. RNA editing is usually understood as post-transcriptional RNA processing (except ca...
Recent Advances in RNA m6A Modification in Solid Tumors and Tumor Immunity [0.03%]
固体瘤与肿瘤免疫中的RNA m6A修饰研究新进展
Michelle Verghese,Emma Wilkinson,Yu-Ying He
Michelle Verghese
An analogous field to epigenetics is referred to as epitranscriptomics, which focuses on the study of post-transcriptional chemical modifications in RNA. RNA molecules, including mRNA, tRNA, rRNA, and other non-coding RNA molecules, can be ...
Recent Advances of RNA m6A Modifications in Cancer Immunoediting and Immunotherapy [0.03%]
癌症免疫编辑和免疫治疗中RNA m六A修饰的研究进展
Shoubao Ma,Tasha Barr,Jianhua Yu
Shoubao Ma
Cancer immunotherapy, which modulates immune responses against tumors using immune-checkpoint inhibitors or adoptive cell transfer, has emerged as a novel and promising therapy for tumors. However, only a minority of patients demonstrate du...
Jonas Cerneckis,Qi Cui,Wei Liu et al.
Jonas Cerneckis et al.
Post-transcriptional regulation of gene expression shapes the cell state both in health and disease. RNA modifications-especially N6-methyladenosine (m6A)-have recently emerged as key players in RNA processing that depends on a sophisticate...
Ying Qing,Dong Wu,Xiaolan Deng et al.
Ying Qing et al.
RNA modifications have recently been recognized as essential posttranscriptional regulators of gene expression in eukaryotes. Investigations over the past decade have revealed that RNA chemical modifications have profound effects on tumor i...
WRN Is a Promising Synthetic Lethal Target for Cancers with Microsatellite Instability (MSI) [0.03%]
WRN是微卫星不稳定型癌症的有前景的合成致死靶点
Edmond M Chan,Kyla J Foster,Adam J Bass
Edmond M Chan
Microsatellite instability (MSI), a type of genetic hypermutability arising from impaired DNA mismatch repair (MMR), is observed in approximately 3% of all cancers. Preclinical work has identified the RecQ helicase WRN as a promising synthe...