A role for synaptic inputs at distal dendrites: instructive signals for hippocampal long-term plasticity [0.03%]
远突触输入在顶树突上的作用：海马长期可塑性的指导信号
Joshua T Dudman,David Tsay,Steven A Siegelbaum
Joshua T Dudman
Synaptic potentials originating at distal dendritic locations are severely attenuated when they reach the soma and, thus, are poor at driving somatic spikes. Nonetheless, distal inputs convey essential information, suggesting that such inpu...
Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1 [0.03%]
谷氨酸能神经元通过GAT-1 逆向转运释放抑制性递质gamma-氨基丁酸
Yuanming Wu,Wengang Wang,Ana Díez-Sampedro et al.
Yuanming Wu et al.
GABA transporters play an important but poorly understood role in neuronal inhibition. They can reverse, but this is widely thought to occur only under pathological conditions. Here we use a heterologous expression system to show that the r...
Silke Sachse,Erroll Rueckert,Andreas Keller et al.
Silke Sachse et al.
Olfactory sensory neurons (OSNs) form synapses with local interneurons and second-order projection neurons to form stereotyped olfactory glomeruli. This primary olfactory circuit is hard-wired through the action of genetic cues. We asked wh...
Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK [0.03%]
CDK5通过调节MAGUK家族成员CASPS的亚细胞分布促进突触生成
Benjamin Adam Samuels,Yi-Ping Hsueh,Tianzhi Shu et al.
Benjamin Adam Samuels et al.
Synaptogenesis is a highly regulated process that underlies formation of neural circuitry. Considerable work has demonstrated the capability of some adhesion molecules, such as SynCAM and Neurexins/Neuroligins, to induce synapse formation i...
Gating of Sema3E/PlexinD1 signaling by neuropilin-1 switches axonal repulsion to attraction during brain development [0.03%]
神经纤连蛋白-1通过调控Sema3E/PlexinD1信号转导在脑发育中将轴突排斥转换为吸引作用
Sophie Chauvet,Samia Cohen,Yutaka Yoshida et al.
Sophie Chauvet et al.
The establishment of functional neural circuits requires the guidance of axons in response to the actions of secreted and cell-surface molecules such as the semaphorins. Semaphorin 3E and its receptor PlexinD1 are expressed in the brain, bu...
Tiling of r7 axons in the Drosophila visual system is mediated both by transduction of an activin signal to the nucleus and by mutual repulsion [0.03%]
果蝇视觉系统中r7轴突铺展受活化素信号传导和互斥机制的调控
Chun-Yuan Ting,Tory Herman,Shinichi Yonekura et al.
Chun-Yuan Ting et al.
The organization of neuronal wiring into layers and columns is a common feature of both vertebrate and invertebrate brains. In the Drosophila visual system, each R7 photoreceptor axon projects within a single column to a specific layer of t...
Different processing phases for features, figures, and selective attention in the primary visual cortex [0.03%]
视皮层中特征、图形和选择注意的不同处理阶段
Pieter R Roelfsema,Michiel Tolboom,Paul S Khayat
Pieter R Roelfsema
Our visual system imposes structure onto images that usually contain a diversity of surfaces, contours, and colors. Psychological theories propose that there are multiple steps in this process that occur in hierarchically organized regions ...
Inhibition and brain work [0.03%]
抑制和脑力劳动
György Buzsáki,Kai Kaila,Marcus Raichle
György Buzsáki
The major part of the brain's energy budget ( approximately 60%-80%) is devoted to its communication activities. While inhibition is critical to brain function, relatively little attention has been paid to its metabolic costs. Understanding...
Joseph Glykys,Istvan Mody
Joseph Glykys
Some GABA(A) receptors (GABA(A)Rs) are activated by low transmitter levels present in the extracellular space and generate an uninterrupted conductance referred to as "tonic." This tonic conductance is highly sensitive to all factors regula...
Wilder Penfield in the age of YouTube: visualizing the sequential activation of sensorimotor areas across neocortex [0.03%]
威利尔·潘菲尔德进入YouTube时代：皮层感觉运动区的顺序激活现象可视化观测
David Kleinfeld,Jack Waters
David Kleinfeld
Flow of electrical activity across neocortex is essential for many sensorimotor tasks. Whether this flow is localized or spreads widely is unknown. Ferezou et al., imaging activity across the cortical mantle in awake mice, show in this issu...