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Neuron. 2007 Dec 6;56(5):851-65. doi: 10.1016/j.neuron.2007.10.021 Q115.02025

Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1

谷氨酸能神经元通过GAT-1 逆向转运释放抑制性递质gamma-氨基丁酸 翻译改进

Yuanming Wu  1, Wengang Wang, Ana Díez-Sampedro, George B Richerson

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  • 1 Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA.
  • DOI: 10.1016/j.neuron.2007.10.021 PMID: 18054861

    摘要 Ai翻译

    GABA transporters play an important but poorly understood role in neuronal inhibition. They can reverse, but this is widely thought to occur only under pathological conditions. Here we use a heterologous expression system to show that the reversal potential of GAT-1 under physiologically relevant conditions is near the normal resting potential of neurons and that reversal can occur rapidly enough to release GABA during simulated action potentials. We then ... ...点击完成人机验证后继续浏览
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    期刊名:Neuron

    缩写:NEURON

    ISSN:0896-6273

    e-ISSN:1097-4199

    IF/分区:15.0/Q1

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    Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1