Philip S Choi,Lisa Zakhary,Wen-Yee Choi et al.
Philip S Choi et al.
MicroRNAs (miRNAs) are highly expressed in vertebrate neural tissues, but the contribution of specific miRNAs to the development and function of different neuronal populations is still largely unknown. We report that miRNAs are required for...
Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm [0.03%]
胞质内聚集的延长全长亨廷顿蛋白诱导神经退行性抑制和突触传递增强
Eliana Romero,Guang-Ho Cha,Patrik Verstreken et al.
Eliana Romero et al.
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by expansion of a translated CAG repeat in the N terminus of the huntingtin (htt) protein. Here we describe the generation and characterization of a full-...
Multisensory interplay reveals crossmodal influences on 'sensory-specific' brain regions, neural responses, and judgments [0.03%]
多感官交互揭示了跨模式对“特定感觉”大脑区域、神经反应和判断的影响
Jon Driver,Toemme Noesselt
Jon Driver
Although much traditional sensory research has studied each sensory modality in isolation, there has been a recent explosion of interest in causal interplay between different senses. Various techniques have now identified numerous multisens...
Ac-ing the clock [0.03%]
争分夺秒
Amita Sehgal
Amita Sehgal
Circadian clock proteins are modified in many different ways. The best-studied posttranslational modification is phosphorylation, with well-known kinases and phosphatases regulating the function and stability of clock proteins. Degradation ...
Angharad M Kerr,Peter Jonas
Angharad M Kerr
Two studies in this issue of Neuron (Kwon and Castillo and Rebola et al.) show that the mossy fiber-CA3 pyramidal neuron synapse, a hippocampal synapse well known for its presynaptic plasticity, exhibits a novel form of long-term potentiati...
From neuronal activity to the actin cytoskeleton: a role for CaMKKs and betaPIX in spine morphogenesis [0.03%]
从神经元活动到肌动蛋白细胞骨架：CaMKK和betaPIX在突触形态发生中的作用
Lorenza Ciani,Patricia C Salinas
Lorenza Ciani
Electrical activity plays a crucial role in neuronal circuit assembly. Activation of NMDA receptors induces the elevation of intracellular calcium, resulting in the modulation of calcium-calmodulin-dependent protein kinases (CaMKs). The CaM...
Patrick Dolph
Patrick Dolph
Studies of the Drosophila visual system have provided valuable insights into the function and regulation of phototransduction signaling pathways. Much of this work has stemmed from or relied upon the genetic tools offered by the Drosophila ...
Endogenous cortical rhythms determine cerebral specialization for speech perception and production [0.03%]
内源性皮层节律决定大脑的语言感知和产生的专门化功能
Anne-Lise Giraud,Andreas Kleinschmidt,David Poeppel et al.
Anne-Lise Giraud et al.
Across multiple timescales, acoustic regularities of speech match rhythmic properties of both the auditory and motor systems. Syllabic rate corresponds to natural jaw-associated oscillatory rhythms, and phonemic length could reflect endogen...
Uri Hasson,Jeremy I Skipper,Howard C Nusbaum et al.
Uri Hasson et al.
Is there a neural representation of speech that transcends its sensory properties? Using fMRI, we investigated whether there are brain areas where neural activity during observation of sublexical audiovisual input corresponds to a listener'...
Developmental switch in neuropeptide Y and melanocortin effects in the paraventricular nucleus of the hypothalamus [0.03%]
下丘脑视上核中神经肽Y和黑素皮质素作用的发育转换
Igor Melnick,Nina Pronchuk,Michael A Cowley et al.
Igor Melnick et al.
Homeostatic regulation of energy balance in rodents changes dramatically during the first 3 postnatal weeks. Neuropeptide Y (NPY) and melanocortin neurons in the arcuate nucleus, a primary energy homeostatic center in adults, do not fully i...