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Neuron. 2008 Jan 10;57(1):27-40. doi: 10.1016/j.neuron.2007.11.025 Q115.02025

Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm

胞质内聚集的延长全长亨廷顿蛋白诱导神经退行性抑制和突触传递增强 翻译改进

Eliana Romero  1, Guang-Ho Cha, Patrik Verstreken, Cindy V Ly, Robert E Hughes, Hugo J Bellen, Juan Botas

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  • 1 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  • DOI: 10.1016/j.neuron.2007.11.025 PMID: 18184562

    摘要 Ai翻译

    Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by expansion of a translated CAG repeat in the N terminus of the huntingtin (htt) protein. Here we describe the generation and characterization of a full-length HD Drosophila model to reveal a previously unknown disease mechanism that occurs early in the course of pathogenesis, before expanded htt is imported into the nucleus in detectable amounts. We find that expanded f... ...点击完成人机验证后继续浏览
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    期刊名:Neuron

    缩写:NEURON

    ISSN:0896-6273

    e-ISSN:1097-4199

    IF/分区:15.0/Q1

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    Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm