PAPA-1 Is a nuclear binding partner of IGFBP-2 and modulates its growth-promoting actions [0.03%]
PAPA-1是IGFBP-2的核结合蛋白并调节其促生长作用
Kenichi Miyako,Laura J Cobb,Malik Francis et al.
Kenichi Miyako et al.
IGF-binding proteins (IGFBPs) have multiple cellular effects, which occur by both IGF-dependent and -independent mechanisms. IGFBP-2 is involved in the regulation of both normal and carcinogenic cell growth. To further understand the action...
Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity [0.03%]
雌激素通过调节蛋白酪氨酸磷酸酶PTPRO基因在人类乳腺癌中的作用机制及其对三苯氧胺敏感性的影响
Bhuvaneswari Ramaswamy,Sarmila Majumder,Satavisha Roy et al.
Bhuvaneswari Ramaswamy et al.
We have previously demonstrated the tumor suppressor characteristics of protein tyrosine phosphatase receptor-type O (PTPRO) in leukemia and lung cancer, including its suppression by promoter methylation. Here, we show tumor-specific methyl...
Molecular mechanism of action of pharmacoperone rescue of misrouted GPCR mutants: the GnRH receptor [0.03%]
药物药理伴侣蛋白对垂体促性腺激素释放激素受体错路突变型的分子修复机制研究
Jo Ann Janovick,Akshay Patny,Ralph Mosley et al.
Jo Ann Janovick et al.
The human GnRH receptor (hGnRHR), a G protein-coupled receptor, is a useful model for studying pharmacological chaperones (pharmacoperones), drugs that rescue misfolded and misrouted protein mutants and restore them to function. This techni...
Minireview: latest perspectives on antiinflammatory actions of glucocorticoids [0.03%]
minireview：糖皮质激素抗炎作用的最新观点
Karolien De Bosscher,Guy Haegeman
Karolien De Bosscher
Taking into consideration that glucocorticoid (GC) hormones have been used clinically for over half a century and that more than 20 yr have passed since the cloning of the GC receptor (GR), it is hard to imagine that novel aspects in the mo...
FoxO1 mediates PTEN suppression of androgen receptor N- and C-terminal interactions and coactivator recruitment [0.03%]
FOXO1介导PTEN对雄激素受体N端和C端相互作用及共激活因子募集的抑制作用
Qiuping Ma,Wei Fu,Pengfei Li et al.
Qiuping Ma et al.
FoxO (mammalian forkhead subclass O) proteins are transcription factors acting downstream of the PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor. Their activity is negatively regulated by AKT-mediated phospho...
Minireview: liver X receptor beta: emerging roles in physiology and diseases [0.03%]
minireview：肝X受体β：生理和疾病中的作用机制
Chiara Gabbi,Margaret Warner,Jan-Ake Gustafsson
Chiara Gabbi
Liver X receptors, LXRalpha and LXRbeta, are nuclear receptors belonging to the large family of transcription factors. After activation by oxysterols, LXRs play a central role in the control of lipid and carbohydrate metabolism as well as i...
Prolactin blocks nuclear translocation of VDR by regulating its interaction with BRCA1 in osteosarcoma cells [0.03%]
泌乳素通过调节BRCA1的相互作用来阻止VDR在骨肉瘤细胞中的核转位
Changhui Deng,Eric Ueda,Kuanhui E Chen et al.
Changhui Deng et al.
Based on their content of prolactin receptors, osteosarcoma cells were predicted to be responsive to prolactin (PRL), but whether PRL would be beneficial or contribute to pathogenesis was unclear. 1,25(OH)(2) vitamin D(3) [1alpha,25(OH)(2)D...
E Maria C Ohlsson Teague,Kylie H Van der Hoek,Mark B Van der Hoek et al.
E Maria C Ohlsson Teague et al.
Endometriosis is a prevalent gynecological disease characterized by growth of endometriotic tissue outside the uterine cavity. MicroRNAs (miRNAs) are naturally occurring posttranscriptional regulatory molecules that potentially play a role ...
Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration [0.03%]
CYP7a1基因在肝再生急性期调控的意义及机制研究
Lisheng Zhang,Xiongfei Huang,Zhipeng Meng et al.
Lisheng Zhang et al.
Cholesterol 7alpha-hydroxylase (CYP7a1) is the rate-limiting enzyme in the classic pathway of bile acid synthesis. Expression of CYP7a1 is regulated by a negative feedback pathway of bile acid signaling. Previous studies have suggested that...
SRC family kinases accelerate prolactin receptor internalization, modulating trafficking and signaling in breast cancer cells [0.03%]
SRC家族激酶加速催乳素受体的内吞作用并调节乳腺癌细胞中的转运和信号转导
Timothy M Piazza,Juu-Chin Lu,Kristopher C Carver et al.
Timothy M Piazza et al.
Despite the growing body of evidence supporting prolactin (PRL) actions in human breast cancer, little is known regarding PRL regulation of its own receptor in these cells. Ligand-initiated endocytosis is a key process in the regulation of ...