Down-regulation of hepatic HNF4alpha gene expression during hyperinsulinemia via SREBPs [0.03%]
高胰岛素水平通过SREBPs下调肝HNF4alpha基因表达
Xuefen Xie,Hailing Liao,Huaixin Dang et al.
Xuefen Xie et al.
Mutations in the coding region of hepatocyte nuclear factor 4alpha (HNF4alpha), and its upstream promoter (P2) that drives expression in the pancreas, are known to lead to maturity-onset diabetes of the young 1 (MODY1). HNF4alpha also contr...
DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism [0.03%]
DISP3是一种含有固醇感应结构域的蛋白质，它将甲状腺激素作用与胆固醇代谢联系起来
Martina Zikova,Alicia Corlett,Zdenka Bendova et al.
Martina Zikova et al.
In the body, the brain is the most cholesterol-rich organ. Despite this, remarkably little is known about the mechanisms in the brain that regulate cholesterol homeostasis. Due to the blood-brain barrier, plasma lipoproteins are unable to t...
cAMP-dependent posttranscriptional regulation of steroidogenic acute regulatory (STAR) protein by the zinc finger protein ZFP36L1/TIS11b [0.03%]
ZFP36L1/TIS11b通过cAMP依赖的翻译抑制调控星形活性调节(Star)蛋白的作用机制研究
Haichuan Duan,Nadia Cherradi,Jean-Jacques Feige et al.
Haichuan Duan et al.
Star is expressed in steroidogenic cells as 3.5- and 1.6-kb transcripts that differ only in their 3'-untranslated regions (3'-UTR). In mouse MA10 testis and Y-1 adrenal lines, Br-cAMP preferentially stimulates 3.5-kb mRNA. ACTH is similarly...
Agonist-independent interactions between beta-arrestins and mutant vasopressin type II receptors associated with nephrogenic syndrome of inappropriate antidiuresis [0.03%]
血管加压素Ⅱ型受体突变体与β淀粉样蛋白相互作用导致不适当抗利尿激素性肾性综合征
Martina Kocan,Heng B See,Natália G Sampaio et al.
Martina Kocan et al.
Nephrogenic syndrome of inappropriate antidiuresis is a recently identified genetic disease first described in two unrelated male infants with severe symptomatic hyponatremia. Despite undetectable arginine vasopressin levels, patients have ...
Gonadotropin-releasing hormone and protein kinase C signaling to ERK: spatiotemporal regulation of ERK by docking domains and dual-specificity phosphatases [0.03%]
通过靠位结构域和双特异性磷酸酶对促性腺激素释放激素和蛋白激酶C信号转导至ERK：靠位结构域和双特异性磷酸酶对ERK的时空调节
Stephen Paul Armstrong,Christopher James Caunt,Craig Alexander McArdle
Stephen Paul Armstrong
Activated ERK translocates to the nucleus to regulate transcription. Spatiotemporal aspects of this response dictate biological consequences and are influenced by dual-specificity phosphatases (DUSPs) that can scaffold and dephosphorylate E...
Susceptibility to autoimmunity and B cell resistance to apoptosis in mice lacking androgen receptor in B cells [0.03%]
B细胞缺乏雄激素受体小鼠自身免疫性疾病易感性和B细胞对凋亡的抵抗性
Saleh Altuwaijri,Kuang-Hsiang Chuang,Kuo-Pao Lai et al.
Saleh Altuwaijri et al.
Estrogens have been linked to a higher female incidence of autoimmune diseases. The role of androgen and the androgen receptor (AR) in autoimmune diseases, however, remains unclear. Here we report that the lack of AR in B cells in different...
Insulin regulates TRB3 and other stress-responsive gene expression through induction of C/EBPbeta [0.03%]
胰岛素通过诱导C/EBPβ调节TRB3和其他应激反应基因的表达
Keyong Du,Jixin Ding
Keyong Du
Pseudokinase TRB3 is an inducible gene whose expression is regulated by stress response and insulin and associated with insulin resistance and metabolic syndrome. In this report, we have investigated the mechanism under which insulin regula...
Loss of betaglycan contributes to the malignant properties of human granulosa tumor cells [0.03%]
Betaglycan的丢失有助于人类颗粒细胞肿瘤细胞的恶性表型
Maree Bilandzic,Simon Chu,Paul G Farnworth et al.
Maree Bilandzic et al.
Betaglycan is a type III TGFbeta receptor that modulates cellular sensitivity to inhibins and TGFbeta. Previous studies have suggested that betaglycan acts as a tumor suppressor in certain human epithelial cancers. However, the roles of bet...
Hannelore V Heemers,Kevin M Regan,Lucy J Schmidt et al.
Hannelore V Heemers et al.
Aberrant coregulator expression that occurs during prostate cancer (PCa) progression correlates with poor prognosis and aggressive disease. This has been attributed to the ability to regulate androgen receptor-mediated transcription. We hav...
Interruption of growth hormone signaling via SHC and ERK in 3T3-F442A preadipocytes upon knockdown of insulin receptor substrate-1 [0.03%]
利用RNA干扰技术沉默胰岛素受体底物-1抑制3T3-F442A前脂肪细胞生长激素信号通路中的SHC和ERK
Xiangdong Wang,Ning Yang,Luqin Deng et al.
Xiangdong Wang et al.
Insulin receptor substrate-1 (IRS-1) is a docking protein tyrosine phosphorylated in response to insulin, IGF-1, GH, and other cytokines. IRS-1 has an N-terminal plekstrin homology domain (which facilitates membrane localization), a phospho...