Targeting oxidative stress-NLRP3-apoptotic-steroidogenic axis in doxorubicin-induced testicular toxicity: protective efficacy of ferulic acid niosomes [0.03%]
靶向氧化应激-NLRP3-凋亡-类固醇生成轴以对抗多柔比星所致睾丸毒性：阿魏酸尼奥斯omal保护效力的研究
Mahran Mohamed Abd El-Emam,Aya Elhady Atia,Mona A Bakry et al.
Mahran Mohamed Abd El-Emam et al.
Doxorubicin (DOX) is a commonly prescribed chemotherapeutic agent whose clinical application is limited by its toxicity to rapidly dividing organs, particularly the testes.This study explored the protective potential of ferulic acid-loaded ...
Mycophenolate mofetil induces angiogenesis disorders in zebrafish embryos by inhibiting the mitogen-activated protein kinase signaling pathway [0.03%]
他克莫司致斑马鱼胚胎新生血管发育异常及其机制研究
Mengqi Wan,Zhonghao Xiao,Xiaowen Shi et al.
Mengqi Wan et al.
As a commonly used immunosuppressant, mycophenolate mofetil (MMF) is widely prescribed after organ transplantation because it is not toxic to the liver and kidney. However, its use is associated with certain gastrointestinal toxicity and in...
Reshaping the immune landscape: next-generation microglia-targeted therapies for Alzheimer's disease [0.03%]
重塑免疫图谱：下一代小胶质细胞靶向阿尔茨海默病疗法
Jun Wu,Jueying Zhao,Shen Chen et al.
Jun Wu et al.
Background: Alzheimer's disease (AD) is a significant global health challenge characterized as a multifactorial neurodegenerative disorder, involving amyloid-β (Aβ) and Tau aggregation, neuroinflammation and progressive...
FOXQ1 promotes endometriosis development by enhancing mitochondrial function [0.03%]
FOXQ1通过增强线粒体功能促进子宫内膜异位症的发展
Yu Liu,Mei Chi,Yan Lei et al.
Yu Liu et al.
Background: Endometriosis (EMs) is a pathological condition characterized by the ectopic growth of endometrial tissue outside the uterine cavity. This study aimed to investigate the role of FOXQ1 in the pathogenesis of EM...
Expression and functional characterization of the TRPV3 channel in domestic cat (Felis catus) mature oocytes [0.03%]
家猫（Felis catus）成熟卵母细胞中TRPV3通道的表达和功能表征
Sebastián Vergara,José Duarte-Zúñiga,Claudio Hidalgo et al.
Sebastián Vergara et al.
Background: Intracellular calcium (Ca2+) signaling is essential for oocyte maturation, activation, and fertilization, with repetitive Ca2+ transients elicited at fertilization being critical for egg activation and early e...
Molecular insights into the protective role of nano-naringin in mancozeb-induced testicular damage and infertility [0.03%]
纳米芸香苷对灭克引起的睾丸损伤和不育的保护作用的分子见解
Eman I Hassanen,Sara S Elbagwry,Zienab E Eldin et al.
Eman I Hassanen et al.
Mancozeb (MZ) is an extensively used fungicide with well-documented reproductive toxicity induced by oxidative stress and hormonal disruption. Antioxidants such as naringin (NAR) have been studied as protective agents, but their therapeutic...
Telomerase as a therapeutic Bullseye: advances in cancer treatment and clinical trials : A comprehensive review of small molecule inhibitors, antisense oligonucleotides, and immunotherapeutic strategies targeting the telomerase catalytic subunit (hTERT) [0.03%]
靶向端粒酶治疗癌症：小分子抑制剂、反义寡核苷酸和免疫疗法临床试验进展及基础研究综合述评
Ansar Hussain,Musavir Abbas,Ming Long et al.
Ansar Hussain et al.
Telomeres play a crucial role in maintaining genomic stability in healthy cells. However, they gradually shorten during the cell cycle, leading to chromosomal instability. Telomere length and telomerase activity are vital factors that count...
Tissue-specific reference gene stability for qPCR in thermally conditioned quail embryos [0.03%]
热处理鹌鹑胚胎中用于qPCR的组织特异性参考基因稳定性研究
Mohd Matin Ansari,K Martina,Gautham Kolluri et al.
Mohd Matin Ansari et al.
The reliability and accuracy of relative quantification of transcripts through quantitative real-time PCR (qPCR) is dependent on the use of stable reference genes for normalization. However, the expression stability of various reference gen...
Phenotyping of post-fertilization sperm mitophagy determinants discovered in a mammalian gamete-based cell-free system [0.03%]
基于哺乳动物卵子的无细胞体系鉴定参与受精后精子线粒体自噬的表型及决定因素
Alexis Jones,Natálie Zelenková,Erica Mantle et al.
Alexis Jones et al.
The targeted, substrate-specific degradation of paternal mitochondria inside the zygote, known as post-fertilization sperm mitophagy, is a crucial and evolutionarily conserved early embryonic event. It ensures the exclusive maternal inherit...
Impact of Salvadora persica aqueous extract on follicular development in female rats [0.03%]
塞瓦拉 Persica 水提取物对雌性大鼠卵泡发育的影响
Sabreen M Ghareeb,Mahmoud Abd-Elkareem,Ahmed Abou-Elmagd
Sabreen M Ghareeb
Salvadora persica (miswak) has many useful biological activities. Some studies have reported that miswak can be used as a contraceptive agent. However, no available investigations explain the histomorphological structure of ovarian follicle...