[Treadmill exercise improves constipation in mice with chronic Parkinson's disease through activating autophagy] [0.03%]
跑步机运动通过激活自噬缓解慢性帕金森病模型小鼠便秘研究
Bi-Hui Nie,Yuan Gao,Xiao-Qian Liu et al.
Bi-Hui Nie et al.
This study aimed to explore the effects and molecular mechanisms of 8-week treadmill exercise on constipation symptoms in mice with chronic Parkinson's disease (PD). Forty C57BL/6 mice were randomly divided into four groups: control group, ...
[Reward value encoded by electrocorticography (ECoG) power spectrum in the prefrontal cortex] [0.03%]
前额叶电皮层记录(ECoG)功率谱的奖赏价值编码
Shen-Hua Lin,Yi-Hong Wang,Xu-Ying Xu et al.
Shen-Hua Lin et al.
Calculating reward value is a core component in the value-based decision-making process, where the brain guides behavioral choices by evaluating the reward values of different options. The prefrontal cortex (PFC), a central hub for higher-o...
[Hippocampal stereotactic injection of cerebrospinal fluid from single-prolonged stress mice induces PTSD-like behavior] [0.03%]
单侧延长应激小鼠脑脊液的海马立体定位注射诱发 PTSD 样行为
Ke-Ke Ding,Dao-Kang Chen,Shao-Jie Yang et al.
Ke-Ke Ding et al.
This study aimed to investigate the impact of cerebrospinal fluid (CSF) from single-prolonged stress (SPS) model mice on the neurobehavioral outcomes in normal mice, and to explore the underlying mechanisms. CSF was extracted from SPS mice ...
[Inhibition of activation of astrocytes in dorsal hippocampal CA1 relieves lipopolysaccharide-induced cognitive impairment] [0.03%]
抑制海马CA1区星形胶质细胞活化缓解脂多糖所致认知障碍
Si-Qi Jing,Ying Zhang,Wei-Guo Shi et al.
Si-Qi Jing et al.
This study aimed to investigate whether inhibiting the activation of astrocytes in the dorsal hippocampal CA1 (dCA1) region could ameliorate lipopolysaccharide (LPS)-induced cognitive impairment in mice. Mice were intraperitoneally injected...
Peng-Yu Chen,Hua Guo,Yu-Nan Wang et al.
Peng-Yu Chen et al.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Defects in the regulatory T cells (Treg cells) play a key role in breaking immune tolerance in SLE patients. This study investigates the causes of impaired Treg cell functi...
[Engulfment of senescent erythrocytes by endothelial cells promotes endothelial-to-mesenchymal transition] [0.03%]
衰老红细胞被内皮细胞吞噬促进内皮-间充质转化
Cheng-Lin Huang,Wei-Li Shen
Cheng-Lin Huang
Endothelial cells, as non-professional phagocytes, play a role in clearing senescent red blood cells (RBCs). This study explores the phenotypic differentiation of endothelial cells following the phagocytosis of senescent RBCs. A hypertensiv...
[Research progress on the role of miR-132 in the pathogenesis of depression] [0.03%]
抑郁症发病机制中miR-132作用的研究进展
Ding-Lun Meng,Qing-Yan Wang,Xin Zhang et al.
Ding-Lun Meng et al.
The prevalence of depression, a common mental disorder in clinical practice, has been continuously increasing in recent years, with its intricate etiology and pathogenesis incompletely understood. MicroRNA (miRNA), a highly conserved and wi...
[The role and mechanism of branched-chain amino acids in tumorigenesis and progression] [0.03%]
支链氨基酸在肿瘤发生发展中的作用及机制研究进展
Ren Zheng,Chen-Chen Hu,Yuan-Jie Sun et al.
Ren Zheng et al.
As essential amino acids, branched-chain amino acids (BCAAs) have attracted much attention in the field of tumor metabolism in recent years. This article reviews the metabolic characteristics of BCAAs in tumors and discusses their involveme...
[Advances in the regulation of pancreatic islet β-cell identity plasticity by exercise in type 2 diabetes mellitus] [0.03%]
运动改善2型糖尿病胰岛β细胞身份可塑性的表观遗传机制研究进展
Ke Yao,Nan-Nan Jia,Hang Chu et al.
Ke Yao et al.
Loss of pancreatic islet β-cell identity is considered to be one of the major factors for impaired insulin secretion in diabetes mellitus. Pancreatic islet β-cell identity plasticity and the regulatory mechanisms of related factors have a...
[Progress in targeting endogenous neurogenesis for the treatment of ischemic stroke] [0.03%]
[针对内源性神经发生治疗缺血性卒中的研究进展]
Meng-Tao Wang,Hai-Lin DU,Fei Hao et al.
Meng-Tao Wang et al.
Stroke is the leading cause of death and disability in China and the second in the world. A large number of neurons died after ischemic stroke. Due to the limited regenerative capacity of central nervous system, severely restricted neuronal...