[Mechanism of the unstable proteins generated by P346H-BEST1 and P233L-BEST1 mutations and their role in causing RP50 and BVMD] [0.03%]
P346H-BEST1和P233L-BEST1突变诱发不稳定蛋白的机制及其在RP50和BVMD发病中的作用
Qing-Xiang Lu,Jing-Ye Yang,Hong-Xia Tian et al.
Qing-Xiang Lu et al.
BEST1 mutations are associated with a spectrum of ocular disorders collectively termed Bestrophinopathies, including autosomal dominant Best vitelliform macular dystrophy (BVMD), adult-onset vitelliform macular dystrophy (AVMD), autosomal d...
[Effects of interleukin-18 on CD4+PD-1+ T cells may contribute to the pathogenesis of immune thrombocytopenia] [0.03%]
白细胞介素18通过影响CD4+PD-1+T细胞可能参与免疫性血小板减少发病机制
Cen Yi,Cheng Zhang,Pei-Ning Li et al.
Cen Yi et al.
The aim of this study was to investigate the regulatory effect and mechanism of interleukin-18 (IL-18) on the function of human peripheral blood CD4+ programmed death-1 (PD-1)+ T cells , and to explore whether the role of IL-18 was involved...
[Inhibition of cathepsin K improves the learning and memory function of the vascular dementia model rats through blocking pyroptosis pathway] [0.03%]
猫素K抑制通过阻断细胞焦亡通路改善血管性痴呆模型大鼠学习记忆能力
Jia-Yao Qiu,Li Chen,Xin-Yi Wang et al.
Jia-Yao Qiu et al.
The study aimed to investigate the mechanism of cathepsin K (CatK) on hippocampal learning and memory dysfunction in rats with vascular dementia (VD). Sprague-Dawley (SD) male rats were randomly divided into control group (Control), control...
Activation of nociceptin receptor attenuates methamphetamine motivation and relapse in rats: Involvement of phosphorylated CREB and Akt in the nucleus accumbens [0.03%]
伤害性受体激活减轻大鼠安非他明成瘾动机及复吸：伏隔核内CREB和Akt磷酸化参与其中
Yu-Jia Cai,Fang-Min Wang,Miao-Jun Lai et al.
Yu-Jia Cai et al.
Accumulating evidence has highlighted the functional role of the endogenous nociceptin/orphanin FQ peptide (N/OFQ) and its nociceptin opioid receptor (NOP) in alcohol and cocaine reward. However, the effects of NOP agonists on methamphetami...
Yi-Lin Ou,Rui Peng,Shao-Jie Xu et al.
Yi-Lin Ou et al.
Osteoporosis (OP) is a prevalent systemic metabolic bone disease characterized by reduced bone mass and compromised bone microstructure. Recent studies have demonstrated that the occurrence of OP is closely related to the imbalance of bone ...
[Research advances in the role of macrophages in the pathogenesis and treatment of sepsis-induced cardiomyopathy] [0.03%]
脓毒症心肌病发病机制及治疗中巨噬细胞作用的研究进展
Xing-Min Ning,Zi-Kun Pei,Ren-Qi Li et al.
Xing-Min Ning et al.
Sepsis-induced cardiomyopathy (SIC) is a form of myocardial dysfunction induced by sepsis, which significantly increases mortality in septic patients. Its pathogenic mechanisms are highly complex, and there is currently no targeted treatmen...
[The role and mechanism of autophagy regulator mTOR in renal ischemia-reperfusion injury] [0.03%]
mTOR自噬调节剂在肾脏缺血再灌注损伤中的作用及机制研究
Qian Luo,Shu-Han Yang,Xia Gong
Qian Luo
Renal ischemia-reperfusion injury (RIRI) is a major cause of acute kidney injury (AKI) and poor kidney transplantation outcomes. Its pathogenesis is closely related to oxidative stress, autophagy, and endoplasmic reticulum stress, although ...
[The roles and regulatory mechanisms of serum and glucocorticoid-regulated kinase 1 in miscarriage and preeclampsia] [0.03%]
血清和皮质类固醇调节激酶1在流产和子痫前期的作用及调控机制
Chen Ye,Qing-Shen Wu,Xiao-Xuan Sun et al.
Chen Ye et al.
Serum and glucocorticoid-regulated kinase 1 (SGK1) is a serine/threonine kinase belonging to the AGC kinase family. SGK1 is widely expressed in diverse tissues, whose expression and activity are regulated by numerous physiological and patho...
[Advances in the roles and mechanisms of fibroblast growth factor family members in the self-renewal and differentiation of spermatogonial stem cells] [0.03%]
纤维生长因子家族成员在生精干细胞自我更新和分化中的作用及机制研究进展
Guang-Hua Li,Ying Zheng
Guang-Hua Li
The normal process of spermatogenesis constitutes the cornerstone of male fertility, wherein the maintenance and differentiation of spermatogonial stem cells (SSCs) are indispensable factors in regulating male fertility. Members of the fibr...
Jia-Hui Zhao,Ye Wu,Tai-Wei Wang et al.
Jia-Hui Zhao et al.
The assessment of lymphatic drainage function is essential for understanding the role of the lymphatic system in fluid homeostasis, immunosurveillance and disease processes. Conventional methods of evaluation rely on dynamic visualization w...