[Spinal lncRNA_RT1-CE10 attenuates chronic visceral hypersensitivity in rats with irritable bowel syndrome via inhibiting microglial activation] [0.03%]
脊髓长链非编码RNA_RT1-CE10通过抑制微胶质细胞活化缓解肠易激综合征大鼠慢性内脏高敏感性
Zi-Han Liu,Yi-Qian Liu,Qian-Li Zhang et al.
Zi-Han Liu et al.
The purpose of the study was to investigate the role of the long non-coding RNA (lncRNA)_RT1-CE10 and its molecular mechanisms in chronic visceral pain of rats with irritable bowel syndrome (IBS). Sprague-Dawley (SD) rats were exposed to co...
[5-HT1A receptors in the anterior cingulate cortex mediate electroacupuncture to alleviate the affective pain in rats] [0.03%]
前扣带回5-ht1a受体在电针镇痛中的作用
Jie Shen,Kai-Ni Wang,Jie Gao et al.
Jie Shen et al.
This study aimed to investigate the role of 5-hydroxytryptamine 1A (5-HT1A) receptors in the anterior cingulate cortex (ACC) in regulating the affective pain in rats. In the ACC, normal saline (NS), the 5-HT1A receptor agonist 8-OH-DPAT or ...
[Various models of itch induction and their relationship to pain sensitivity] [0.03%]
[多种痒的诱发模型及其与痛敏感性关系的研究]
Xiao-Ran Ding,Xiu-Yi Han,Hong-Wei Sun et al.
Xiao-Ran Ding et al.
Pruritus, a complex multidimensional sensation accompanying diverse dermatological and systemic disorders, affects a substantial global population. Nevertheless, the pathophysiological mechanisms underlying chronic pruritus remain incomplet...
[Single-nucleus transcriptome of the gracile nucleus reveals multi-modular complex functional genes in excitatory projection neurons] [0.03%]
单核转录组揭示了薄束核兴奋性投射神经元的多模态复杂功能基因
Ting Si,Qing-Jian Han
Ting Si
The gracile nucleus (GR), conventionally regarded as a primary relay in the ascending somatosensory pathway, plays a pivotal role in processing fine-touch, vibration, and proprioceptive information originating from the lower body. The fidel...
[Differential effects of GluN2A and GluN2B subunits in the medial prefrontal cortex on chronic pain and anxiety/depressive-like behaviors] [0.03%]
medial前额叶皮层GluN2A和GluN2B亚基在慢性疼痛以及焦虑和抑郁样行为中的不同作用
Jia-Li Ding,Hui-Ran Yang,Yu-Qiu Zhang et al.
Jia-Li Ding et al.
This study aimed to investigate the differential roles of GluN2A and GluN2B subunits of N-methyl-D-aspartate receptor (NMDAR) in the medial prefrontal cortex (mPFC) and their downstream signaling pathways in a mouse model of chronic constri...
Mice with postsurgical pain exhibit age-dependent spinal microglial activation and inhibitory synapse loss [0.03%]
术后疼痛的小鼠表现出脊髓微胶质活化和抑制性突触丧失的年龄依赖性
Jia-Ning Wang,Yu Shen,Shi-Hao Wang et al.
Jia-Ning Wang et al.
Persistent postsurgical pain is a major clinical concern, especially in the aging population, who represent a growing proportion of surgical patients. Although age is a known pain risk factor, the mechanisms driving age-related vulnerabilit...
Oxytocin relieves visceral hypersensitivity through GABAB1-TRPV1 in rats with irritable bowel syndrome [0.03%]
催产素通过GABAB1-TRPV1信号缓解内脏高敏感及肠易激综合征症状
Fei Fan,Yang Cao,Zheng-Qing He et al.
Fei Fan et al.
Oxytocin has been found to modulate and improve pain in humans, but the mechanisms underlying these antinociceptive properties, especially in visceral hypersensitivity, are still unclear. Irritable bowel syndrome (IBS) models were establish...
A glutamatergic Sp5C-STN circuit mediates chronic migraine in mice [0.03%]
小鼠慢性偏头痛的谷氨酸Sp5C-STN环路机制研究
Liu Tang,Ying-Qi Cheng,Wei Gui et al.
Liu Tang et al.
Chronic migraine (CM) is a prevalent and highly debilitating neurological disorder. Functional magnetic resonance imaging (fMRI) studies have demonstrated associations between abnormal brain region activation and CM, yet the underlying comp...
[The involvement of claustrum/insular cortex-locus coeruleus neural pathway in modulating neuropathic pain in mice] [0.03%]
[参与调控小鼠神经病理性疼痛的屏状核/岛叶皮质-蓝斑神经通路]
Lyu-La Pan,Tao Gong,Zi-Ang Li et al.
Lyu-La Pan et al.
To investigate the fiber connections between the claustrum (CLA)/insular cortex (IC) and the locus coeruleus (LC), as well as the role of this neural pathway in neuropathic pain, morphological techniques, patch-clamp recording, and chemogen...
[Mechanistic insights into NLRP3 inflammasome regulation of chronic pain] [0.03%]
[NLRP3炎性小体调控慢性疼痛的机制研究]
Zong-Zhi Yang,Jie Wu,Xiao-Lan Huang et al.
Zong-Zhi Yang et al.
The NLRP3 inflammasome, a pivotal effector of the innate immune system, has emerged as a critical regulator in the initiation and maintenance of chronic pain. Accumulating evidence demonstrates that NLRP3 inflammasome activation in the peri...