Isochalcogenourea-catalyzed asymmetric (4 + 2)-heterocycloadditions of allenoates [0.03%]
异硫氰酸酯催化的丙二烯酸酯的不对称（4+2）-杂环加成反应
Mario Waser
Mario Waser
Allenoates are versatile reagents that can be used for numerous (formal) cycloaddition reactions under (chiral) Lewis base catalysis. Most commonly, the catalysts of choice are phosphines, amines, and N-heterocyclic carbenes. We have recent...
Recognition of mismatched sites in double-stranded DNA by a pair of partially noncomplementary peptide nucleic acids [0.03%]
一对部分非互补肽核酸识别双链DNA错配位点
Masanari Shibata,Osami Shoji,Yuichiro Aiba
Masanari Shibata
We have successfully achieved efficient recognition of mismatched sites in double-stranded DNA through the formation of an invasion complex by using partially noncomplementary peptide nucleic acids (PNAs). Owing to mismatches between 2 PNAs...
Goh Sennari,Hiroki Yamagishi,Richmond Sarpong
Goh Sennari
Camphor and related monoterpenoid natural products have served as versatile "chiral pool" materials in organic chemistry for over half a century. Historically, many researchers have used a variety of transformations involving orchestrated r...
Recent evidence for multifactorial biofilm regulation by heme sensor proteins NosP and H-NOX [0.03%]
近期关于通过血红素传感器蛋白NosP和H-NOX调节多因子生物被膜的证据
Jiayuan Fu,Steven Hall,Elizabeth M Boon
Jiayuan Fu
Heme is involved in signal transduction by either acting as a cofactor of heme-based gas/redox sensors or binding reversely to heme-responsive proteins. Bacteria respond to low concentrations of nitric oxide (NO) to modulate group behaviors...
Two-Step Synthesis of Furans by Mn(III)-Promoted Annulation of Enol Ethers [0.03%]
Mn(III)促进的烯醇醚环化合成呋喃类化合物
E J Corey,Arun K Ghosh
E J Corey
Enol ethers, β-dicarbonyl compounds and the Mn(III) reagent Mn3O(OAc)7 react under mild conditions to form 1-alkoxy-1.2-dihydrofurans in good (70-98%) yields. The latter are readily converted to furans by acid-catalyzed elimination of ROH.
Insights into Protein Allostery in the CsoR/RcnR Family of Transcriptional Repressors [0.03%]
CsoR/RcnR家族转录阻遏蛋白变构机制的见解
Khadine A Higgins,David Giedroc
Khadine A Higgins
CsoR/RcnR transcriptional repressors adopt a disc-shaped, all α-helical dimer of dimers tetrameric architecture, with a four-helix bundle the key structural feature of the dimer. Individual members of this large family of repressors coordi...
Palladium-Catalyzed Highly Regioselective C-3 Arylation of Imidazo[1,5- a]pyridine [0.03%]
钯催化imidazo[1,5-a]pyridine的C-3区域高度选择性芳基化反应
Chunhui Huang,Alexandros Giokaris,Vladimir Gevorgyan
Chunhui Huang
A direct palladium-catalyzed highly regioselective C-3 arylation of imidazo[1,5-a]pyridine with aryl bromides has been developed. This reaction is quite general with respect to the aryl or hetaryl bromide.
Pd(II)-Catalyzed Cross-Coupling of C(sp2 )-H Bonds and Alkyl-, Aryl- and Vinyl-Boron Reagents via Pd(II)/Pd(0) Catalysis [0.03%]
钯催化C(sp2)-H键与烷基、芳基和烯基硼试剂的交叉偶联反应：钯（II）/钯（0）催化体系的研究
Masayuki Wasa,Kelvin S L Chan,Jin-Quan Yu
Masayuki Wasa
Pd(II)-catalyzed cross-coupling of ortho-C-H bonds in benzoic acid and phenylacetic acid amides with alkyl-, aryl- and vinyl-boron reagents have been achieved via Pd(II)/Pd(0) catalysis, demonstrating the unprecedented versatility of C-H ac...
Formation of C-C Bonds via Ruthenium Catalyzed Transfer Hydrogenation: Carbonyl Addition from the Alcohol or Aldehyde Oxidation Level [0.03%]
钌催化转移氢化通过氧化水平的醇或醛形成C-C键的羰基加成反应
Fumitoshi Shibahara,Michael J Krische
Fumitoshi Shibahara
Under the conditions of ruthenium catalyzed transfer hydrogenation employing isopropanol as terminal reductant, π-unsaturated compounds (1,3-dienes, allenes, 1,3-enynes and alkynes) reductively couple to aldehydes to furnish products of ca...