LSD1 silencing inhibits the proliferation, migration, invasion, and epithelial-to-mesenchymal transition of hypopharyngeal cancer cells by inducing autophagy and pyroptosis [0.03%]
沉默LSD1通过诱导自噬和细胞焦亡抑制下咽癌细胞的增殖、迁移、侵袭及上皮间质转化
Hao Wang,Fang Liu
Hao Wang
Hypopharyngeal cancer is a subtype of the head and neck malignancies. We aimed to explore the role of lysine-specific demethylase 1 (LSD1/KDM1A) in the progression of hypopharyngeal cancer and to identify the potential mechanisms. First, LS...
Upregulated TNF-α and lactate following ERK-SGK1 activation in the spinal dorsal horn underlies chronic postsurgical pain [0.03%]
脊髓背角ERK-SGK1活化诱导TNF-α和乳酸积聚导致术后慢性疼痛发生
Yuying Li,Wenjuan Shi,Juanli Dai et al.
Yuying Li et al.
Skin/muscle incision and retraction (SMIR) during surgeries can lead to chronic postsurgical pain (CPSP). The underlying mechanisms are still unclear. In the present study, we showed that SMIR of the thigh induced phosphorylation of extrace...
Comparison of antihypertensive drugs amlodipine and perindopril on blood pressure variability after long-term treatment of hypertension induced by apatinib and bevacizumab [0.03%]
阿帕替尼和贝伐珠单抗诱导的高血压长期治疗过程中氨氯地平与培哚普利对血压变异性的比较研究
Weichao Zhao,Lanbo Liu,Liqiang Chen
Weichao Zhao
The purpose of this study was to elucidate the therapeutic effect of different antihypertensive drugs (amlodipine and perindopril) on hypertension induced by apatinib and bevacizumab. Sixty patients with hypertension treated with apatinib o...
L-limonene reduces aortic artery atherosclerosis by inhibiting oxidative stress/inflammatory responses in diabetic rats fed high-fat diet [0.03%]
D-柠檬烯通过抑制氧化应激/炎症反应减少糖尿病大鼠高脂饮食动脉粥样硬化病变进展
Xia Han,Huaxin Qi,Jiamin Niu
Xia Han
Atherosclerosis, a leading cause of mortality worldwide, is driven by multiple risk factors such as diabetes. Oxidative stress and inflammation assist interrelated roles in diabetes-accelerated atherosclerosis. Thereby, treatment of diabeti...
Angelica sinensis extract induces telomere dysfunction, cell cycle arrest, and mitochondria-mediated apoptosis in human glioblastoma cells [0.03%]
当归诱导胶质瘤细胞端粒功能障碍、细胞周期阻滞和线粒体介导的凋亡作用
Tsung-Liang Ma,Kai-Fu Chang,Xiao-Fan Huang et al.
Tsung-Liang Ma et al.
Glioblastoma (GB) is one of the most aggressive and malignant tumors of the central nervous system. Conventional treatment for GB requires surgical resection followed by radiotherapy combined with temozolomide chemotherapy; however, the med...
Stanniocalcin 2 is induced by estrogen and promotes growth in endometrial cancer via AMPK pathway [0.03%]
雌激素通过AMPK途径诱导子宫内膜癌中调控生长的STC2蛋白的表达
Qianqian Wang,Qiqi Wang,Yiqi Zhao
Qianqian Wang
Stanniocalcin 2 (STC2) is identified as a glycosylated peptide hormone and estrogen-responsive gene in cancer cells. STC2 participates in angiogenesis, cell development, cytoprotection, and calcium and phosphate regulation during the develo...
Collagen type V alpha 2 promotes the development of gastric cancer via M2 macrophage polarization [0.03%]
胶原蛋白V型α2通过M2巨噬细胞极化促进胃癌的发展
Xin Guo,Xiaoqian Bu,Li Yuan et al.
Xin Guo et al.
Gastric cancer is a type of digestive tract cancer with a high morbidity and mortality, which leads to a major health burden worldwide. More research into the functions of the immune system will improve therapy and survival in gastric cance...
Collagen type V alpha 2 promotes the development of gastric cancer via M2 macrophage polarization [0.03%]
胶原蛋白V型_alpha2通过M2巨噬细胞极化促进胃癌的发展
Xin Guo,Xiaoqian Bu,Li Yuan et al.
Xin Guo et al.
Gastric cancer is a type of digestive tract cancer with a high morbidity and mortality, which leads to a major health burden worldwide. More research into the functions of the immune system will improve therapy and survival in gastric cance...
Knockdown of FKBP3 suppresses nasopharyngeal carcinoma cell growth, invasion and migration, deactivated NF-κB/IL-6 signaling pathway through inhibiting histone deacetylase 2 expression [0.03%]
FKBP3基因敲低通过抑制组蛋白去乙酰化酶2表达抑制鼻咽癌细胞生长、侵袭和迁移并失活NF-κB / IL-6信号通路
Jiadi Dong,Jingjing Chen,Qun Li et al.
Jiadi Dong et al.
Nasopharyngeal carcinoma (NPC) is a prevalent malignant tumor worldwide. FKBP3 has been reported to participate in tumorigenesis. Nevertheless, the role and mechanism of FKBP3 in NPC remains unclear. In this study, FKBP3 expression was obse...
Knockdown of FKBP3 suppresses nasopharyngeal carcinoma cell growth, invasion and migration, deactivated NF-κB/IL-6 signaling pathway through inhibiting histone deacetylase 2 expression [0.03%]
FKBP3基因敲低通过抑制组蛋白去乙酰化酶2表达抑制鼻咽癌增殖、浸润和迁移及NF-κB / IL-6信号通路失活
Jiadi Dong,Jingjing Chen,Qun Li et al.
Jiadi Dong et al.
Nasopharyngeal carcinoma (NPC) is a prevalent malignant tumor worldwide. FKBP3 has been reported to participate in tumorigenesis. Nevertheless, the role and mechanism of FKBP3 in NPC remains unclear. In this study, FKBP3 expression was obse...