Assessing neuroprotection in Parkinson's disease: from the animal models to molecular neuroimaging in vivo [0.03%]
帕金森病的神经保护评估：从动物模型到体内分子神经影像学
R Ceravolo,P Sgadò,D Frosini et al.
R Ceravolo et al.
An important goal in Parkinson's Disease research is to identify neuroprotective therapy, and the interaction between basic science and clinical research is needed to discover drugs that can slow or halt the disorder progression. At present...
Marker for a preclinical diagnosis of Parkinson's disease as a basis for neuroprotection [0.03%]
帕金森病的临床前诊断标志物及其神经保护作用基础
Daniela Berg
Daniela Berg
Neuroprotective therapy is a pivotal aim in the treatment of the relentlessly progressive disorder Parkinson's disease. However, more than 60% of the dopaminergic neurons of the substantia nigra have already degenerated, when the diagnosis ...
P A LeWitt
P A LeWitt
Although still a disorder of unknown etiology, Parkinson's disease (PD) has provided a number of clues that have led to clinical trials of neuroprotection. For example, defects in mitochondrial metabolism and evidence for oxidative stress i...
Inhibition of amine oxidases by the histamine-1 receptor antagonist hydroxyzine [0.03%]
抗组胺药羟嗪抑制胺氧化酶
J O&#x;Sullivan,M I O&#x;Sullivan,K E Tipton et al.
J O&#x;Sullivan et al.
The effects of the drug hydroxyzine on the activities of the rat liver monoamine oxidases (EC 1.4.3.6; MAO) and the membrane-bound and soluble forms of bovine semicarbazide-sensitive amine oxidase (EC 1.4.3.6; SSAO) were studied. Hydroxyzin...
Isatin interaction with glyceraldehyde-3-phosphate dehydrogenase, a putative target of neuroprotective drugs: partial agonism with deprenyl [0.03%]
异丙烯与甘油醛-3-磷酸脱氢酶的相互作用，一种潜在的神经保护药物作用靶点：左旋多巴的部分激动效应
A Medvedev,O Buneeva,O Gnedenko et al.
A Medvedev et al.
There is evidence that the binding of deprenyl, a monoamine oxidase (MAO) B inhibitor, and other propargylamines to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is primarily responsible for their neuroprotective and antiapoptotic effect...
Isatin, an endogenous MAO inhibitor, and a rat model of Parkinson's disease induced by the Japanese encephalitis virus [0.03%]
内源性MAO抑制剂吲哚及其在由日本脑炎病毒诱导的帕金森病大鼠模型中的作用
M Minami,N Hamaue,M Hirafuji et al.
M Minami et al.
A single dose of isatin (indole-2,3-dione)(i.p.), an endogenous MAO inhibitor, significantly increased norepinephrine and 5-hydroxytryptamine concentrations in the rat brain and also significantly increased acetylcholine and dopamine (DA) l...
The relationship of early studies of monoamine oxidase to present concepts [0.03%]
早期单胺氧化酶研究与目前概念的关系
I J Kopin
I J Kopin
The development of our understanding of monoamine oxidase (MAO), of its role in the metabolism of amines and of the therapeutic usefulness of MAO inhibitors (MAOIs) have evolved, slowly at times and rapidly at other times, with leaps propel...
Involvement of type A monoamine oxidase in neurodegeneration: regulation of mitochondrial signaling leading to cell death or neuroprotection [0.03%]
A型单胺氧化酶在神经退行性疾病中的作用：调控线粒体信号通路致细胞死亡或神经保护作用
M Naoi,W Maruyama,Y Akao et al.
M Naoi et al.
In neurodegenerative diseases, including Parkinson's and Alzheimer's diseases, apoptosis is a common type of cell death, and mitochondria emerge as the major organelle to initiate death cascade. Monoamine oxidase (MAO) in the mitochondrial ...
Molecular mechanism of the relation of monoamine oxidase B and its inhibitors to Parkinson's disease: possible implications of glial cells [0.03%]
单胺氧化酶B及其抑制剂与帕金森病的关系的分子机制：胶质细胞的可能作用
T Nagatsu,M Sawada
T Nagatsu
Monoamine oxidases A and B (MAO A and MAO B) are the major enzymes that catalyze the oxidative deamination of monoamine neurotaransmitters such as dopamine (DA), noradrenaline, and serotonin in the central and peripheral nervous systems. MA...
Apoptosis inhibition in T cells triggers the expression of proinflammatory cytokines--implications for the CNS [0.03%]
T细胞凋亡抑制促进炎症因子的表达--其在中枢神经系统中的意义
C Scheller,P Riederer,M Gerlach et al.
C Scheller et al.
Stimulation of death receptors such as CD95 or TNF-R1 results in rapid onset of apoptosis. Here we show that inhibition of death receptor-induced apoptosis by the broad range caspase inhibitor ZVAD causes a switch from apoptotic to proinfla...